Homocysteine and its thiolactone-mediated modification of fibrinogen affect blood platelet adhesion

Malinowska, Joanna; Olas, Beata

doi:10.3109/09537104.2011.625509

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Неблагоприятные эффекты гомоцистеина при метаболических нарушениях опосредуются через различные факторы гиперкоагуляции [5,22]. Данные мировой литературы указывают на значительное увеличение уровня фибриногена, числа тромбоцитов и высвобождаемых ими прокоагулянтных микрочастиц в ответ на введение гомоцистеина [23][24][25][26], однако результаты исследований в отношении показателей тромбодинамики при ГГЦ спорны. По данным R. Marchi и соавт., уровень гомоцистеина в крови не оказывает значимого влияния на показатели тромбодинамики [27].…”

Section: Discussionunclassified

“…При проведении масс-спектрометрического анализа фибриногена установлена возможность его гомоцистеинилирования, что ассоциировано с модификацией α С-домена, нарушениями латеральной ассоциации волокон и связывания с кальцием, приводящими к повреждению структуры фибринового сгустка. Более того, гомоцистеинилирование фибриногена за счет влияния на активность и процессы связывания с фибринолитическими ферментами приводят к увеличению резистености к фибринолизу [23,28]. Также в литературе описана гомоцистеин-опосредованная активация прокоагулянтного потенциала красных клеток крови посредством высвобождения микрочастиц [26].…”

Section: Discussionunclassified

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Assessment of Hemostasis System and Factors Associated With Hypercoagulation in Men With Metabolic Syndrome and Initial Decrease of Glomerular Filtration Rate

Худякова¹,

Беззубова²,

Пчелин³

et al. 2017

Nefrologiâ (St.-Peterbg.)

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THE AIM. To assess hypercoagulation factors in men with initial decrease of glomerular filtration rate (IDGFR) and metabolic syndrome (MS) depending on carbohydrate metabolism disorders (CMD). PATIENTS AND METHODS. The study included 79 men with IDGFR and MS. Two groups were assessed: main – patients IDGFR and CMD with MS (n=44) and control group – with IDGFR and MS without CMD (n=35). Besides examinations for confirming IDGFR and CMD type specification all patients were performed following tests: estimated thrombodynamics factors, serum concentration of common testosterone (CT), leptin (L), adiponectin (A), D-dimer (DD), activated platelets count (CD41+CD62P+) (APC), PAI-1, homocysteine (H). We also studied polymorphism of the genes associated with hyperhomocysteinemia (HHC). RESULTS. 90% cases of hyperhomocysteinemia (HHC) in men with IDGFR and MS were associated with genetic defects in enzyme systems regulating this amino acid metabolism.. Patients from the main group in comparison with the subjects without CMD had significantly higher density of the fibrin clot (28012,21±1013,60 vs. 25209,15±1176,90 c.u., р<0,05), serum levels of PAI-1 (78,78±13,00 vs. 43,66±4,00 ng/ml, p<0,01), leptin (13,56±1,40 vs. 8,95±1,60 ng/ml, p<0,01) and lower serum concentration of CT (11,54±0,70 vs. 14,50±1,10 nmol/l, p<0,05). In men with IDGFR and MS with CMD we found positive correlations between activated platelets count and fasting glucose (rs=0,4; р<0,05), activated platelets count and postprandial glucose (rs=0,5; р<0,05), PAI-1 and adiponectin (rs=0,4; р<0,05), PAI-1 and leptin (rs=0,4; р<0,05), homocysteine and MCH (rs=0,5; р<0,05), homocysteine and density of the fibrin clot (rs=0,5; р<0,05), insulin and PAI-1 (rs=0,4; р<0,05), adiponectin and density of the fibrin clot (rs=0,4; р<0,05), hemoglobin and clot growth rate (rs=0,4; р<0,05), RDW and D-dimer (rs=0,4; р<0,05), RDW and density of the fibrin clot (rs=0,6; р<0,05); a negative correlation – between fasting glucose and adiponectin (rs= -0,4; р<0,05). CONCLUSION. CMD in men with IDGFR and MS are associated with procoagulant status via direct and indirect influence on hypercoaculation factors. The role of adiponectin in thrombogenesis is controversial and requires further investigations.

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Section: Discussionunclassified

Assessment of Hemostasis System and Factors Associated With Hypercoagulation in Men With Metabolic Syndrome and Initial Decrease of Glomerular Filtration Rate

Худякова¹,

Беззубова²,

Пчелин³

et al. 2017

Nefrologiâ (St.-Peterbg.)

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“…Resultados: Três dos quatro pacientes jovens estudados apresentaram indicadores de trombofilia. O resto dos parâmetros alterados foram homocisteína 30,1% (22,4-39,1), lipoproteína (a) 32,1% (24,1-41,4), inibidor do ativador de plasminogênio-1 36,0% (27,1), fibrinogênio 12,3% (7,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)6) e proteína C reativa 78,1% (69,6-84,7). Foi encontrada associação (p<0,05) entre alguns fatores de risco cardiovascular e os parâmetros avaliados como hipertensão/ proteína C reativa, dislipidemia/lipoproteína (a), arritmia/lipoproteína (a) e arritmia/fibrinogênio.…”

Section: Introductionunclassified

“…La Hcis, un producto intermediario del metabolismo de la metionina, es un aminoácido de 4 carbonos con un grupo tiol libre. Se ha reportado que está asociada a una alteración del estado oxidativo que afecta el endotelio, teniendo su elevación un rol predictivo del riesgo aterotrombótico (15,18,19) . Además, estudios indican un aumento de susceptibilidad al ACVi en sujetos hipertensos con Hcis elevada (20) .…”

Section: Introductionunclassified

Evaluación de parámetros inflamatorios, trombóticos y variantes genéticas en pacientes con ataque cerebrovascular isquémico que se asisten en un hospital de Uruguay

2023

RUMI

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Introduction: Stroke is the second cause of death in adults in the Western world and one of the main causes of permanent disability, increasing in frequency with age; 85% are ischemic. Objectives:To analyze thrombophilic, hypofibrinolytic, inflammatory, and genetic parameters in patients with ischemic stroke and evaluate possible associations with vascular risk factors.Methodology: Questionnaires were used to evaluate vascular risk factors in 114 patients included in the study with ischemic stroke diagnosis. Protein C and Antithrombin were determined by chromogenic assays, Activated Protein C Resistance and Lupus Anticoagulant were determined with by coagulometry and Free Protein S, Plasminogen activator inhibitor-1, Homocysteine and Lipoprotein (a) by immunochemistry. Fibrinogen was assayed by coagulometry and C-reactive protein by immunoturbidimetry, both against a control group. Factor V Leiden, Prothrombin G20210A, rs1205 (CRP gene), rs1800779 (NOS3 gene) and rs2257073 (ASB10 gene) genetic variants were analyzed by Real-Time PCR, comparing the last three with a reference population. Alteration frequencies of the variables were determined by chi-square statistical analysis.Results: Three out of four of the young patients studied presented indicators of thrombophilia.

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Spontaneous Release of Human Serum Albumin S-Bound Homocysteine in a Thiol-Free Physiological Medium

Zinellu

Sotgia

Mangoni

et al. 2017

Int J Pept Res Ther

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Homocysteine and its thiolactone-mediated modification of fibrinogen affect blood platelet adhesion

Cited by 5 publications

References 20 publications

Assessment of Hemostasis System and Factors Associated With Hypercoagulation in Men With Metabolic Syndrome and Initial Decrease of Glomerular Filtration Rate

Assessment of Hemostasis System and Factors Associated With Hypercoagulation in Men With Metabolic Syndrome and Initial Decrease of Glomerular Filtration Rate

Evaluación de parámetros inflamatorios, trombóticos y variantes genéticas en pacientes con ataque cerebrovascular isquémico que se asisten en un hospital de Uruguay

Spontaneous Release of Human Serum Albumin S-Bound Homocysteine in a Thiol-Free Physiological Medium

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