Homocysteine induces oxidative stress in young adult central retinal vein occlusion

Devi, Subramaniam Rajesh Bharathi; Suganeswari, G; Sharma, Tarun; Maruthamuthu, Thennarasu; Angayarkanni, Narayanasamy

doi:10.1136/bjophthalmol-2011-301370

Cited by 21 publications

(13 citation statements)

References 41 publications

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“…Wang et al [27] showed a significant association between serum homocysteine and oxidative stress in elderly patients with obstructive sleep apnea syndrome. It was also demonstrated that homocysteine increased the oxidative stress levels dose-and time-dependely in cultured bovine retinal endothelial cells [28]. These findings might be consistent with our present finding indicating that plasma total homocysteine levels were correlated with plasma 8-iso-PG F2α levels.…”

Section: Relationship Between Membrane Fluidity Of Red Blood Cells Ansupporting

confidence: 93%

Hyperhomocysteinemia and Increased Oxidative Stress Levels Are Associated with Impaired Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men: An Electron Spin Resonance Investigation

Tsuda¹

2013

IJCM

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Hyperhomocysteinemia and oxidative stress may be strongly linked to hypertension, atherosclerosis and other cardiovascular diseases. The present study was performed to investigate possible relationships among plasma total homocysteine, plasma 8-iso-prostaglandin F2α (8-isoPG F2α: an index of oxidative stress), and membrane fluidity (a reciprocal value of membrane microviscosity) in hypertension. We measured the membrane fluidity of red blood cells (RBCs) in hypertensive and normotensive men using an electron spin resonance (ESR) and spin-labeling method. Membrane fluidity of RBCs was significantly decreased in hypertensive men compared with normotensive men. Plasma total homocysteine levels were significantly higher in hypertensive men than in normotensive men, and correlated with plasma 8-isoPG F2α. In contrast, plasma nitric oxide (NO)-metabolites (an index of endothelial function) were lower in hypertensive men than in normotensive men. The reduced membrane fluidity of RBCs was associated with increased total homocysteine and plasma 8-isoPG F2α levels and decreased plasma NO-metabolite levels. Multivariate regression analysis showed that, after adjusting for general risk factors, plasma total homocysteine and 8-isoPG F2α were significant determinants of membrane fluidity of RBCs, respectively. These results suggest that hyperhomocysteinemia and oxidative stress with endothelial dysfunction might have a close correlation with impaired rheologic behavior of RBCs and circulatory disorders in hypertensive men.

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Section: Relationship Between Membrane Fluidity Of Red Blood Cells Ansupporting

confidence: 93%

Hyperhomocysteinemia and Increased Oxidative Stress Levels Are Associated with Impaired Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men: An Electron Spin Resonance Investigation

Tsuda¹

2013

IJCM

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“…In most of these cases, CRVO occurs without the presence of the typical risk factors, and a comprehensive workup is warranted [2]. Unusual causes for CRVO in young patients include hypercoagulability states, collagen vascular diseases, lymphoproliferative disorders, malignant hypertension, medications (most notably oral contraceptives and isotretinoin), and trauma [2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13]. A recent study has demonstrated that hyperlipidemia and hyperhomocysteinemia were the most significant risk factors for CRVO in patients under 40 [14].…”

Section: Introductionmentioning

confidence: 99%

Intense Exercise Causing Central Retinal Vein Occlusion in a Young Patient: Case Report and Review of the Literature

Moisseiev¹,

Sagiv

Lazar³

2014

Case Rep Ophthalmol

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We report a 19-year-old patient who developed a central retinal vein occlusion (CRVO) with significant macular edema and visual impairment following intense exercise and dehydration. The patient was treated with 3 intravitreal bevacizumab injections with complete resolution. A review of the literature on the cause and treatment for CRVO in young patients was performed, focusing on the role of intense exercise and dehydration as a rare pathogenesis mechanism of CRVO.

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“…We observed this in our earlier study in CRVO. 47 Thus, Hcy and its metabolite, HcyTL, affect protein function through homocysteinylation. 17 There is oxidative stress and poor oxidant defence in ED.…”

Section: Discussionmentioning

confidence: 99%

Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales’ disease

et al. 2013

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Background: Eales' disease (ED) is an idiopathic retinal vascular disorder. It presents with inflammation and neovascularization in the retina. Adult men, aged between 15 and 40 years are more susceptible than women. Homocysteine has been implicated in other ocular diseases including age-related macular degeneration (ARMD), central retinal vein occlusion (CRVO) and optic neuropathy. The present study investigates the role of homocysteine in ED. Methods: Forty male subjects, 20 with ED and 20 healthy controls, were recruited to the study. Their blood samples were used to measure thiobarbituric acid reactive substances (TBARS), glutathione (GSH), homocysteine, homocysteine-thiolactone, extent of homocysteine conjugation with proteins and plasma copper concentration. Results: In the ED group, plasma homocysteine (18.6 AE 1.77 mmol/L, P < 0.001) and homocysteine-thiolactone (45.3 AE 6.8 nmol/L, P < 0.0001) concentrations were significantly higher compared to homocysteine (11.2 AE 0.64 mmol/L) and homocysteine-thiolactone (7.1 AE 0.94 nmol/L) concentrations in control subjects. TBARS (P < 0.011) and protein homocysteinylation (P < 0.030) were higher in the ED group while GSH (5.9 AE 0.44 mmol/L, P < 0.01) and copper (6.6 AE 0.42 mmol/L, P < 0.001) were lower compared to GSH (8.1 AE 0.41 mmol/L) and copper (15.4 AE 0.73 mmol/L) concentrations in control subjects. Conclusions: Increased homocysteine, and its metabolite thiolactone, is associated with the functional impairment of protein due to homocysteinylation in ED.

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Homocysteine induces oxidative stress in young adult central retinal vein occlusion

Abstract: TBARS and homocysteine are known to be independent risk factors for CRVO. TBARS can be influenced by both homocysteine and TAC, thereby contributing to the aetiopathology of CRVO by increasing oxidative stress.

Cited by 21 publications

References 41 publications

Hyperhomocysteinemia and Increased Oxidative Stress Levels Are Associated with Impaired Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men: An Electron Spin Resonance Investigation

Hyperhomocysteinemia and Increased Oxidative Stress Levels Are Associated with Impaired Membrane Fluidity of Red Blood Cells in Hypertensive and Normotensive Men: An Electron Spin Resonance Investigation

Intense Exercise Causing Central Retinal Vein Occlusion in a Young Patient: Case Report and Review of the Literature

Increased homocysteine, homocysteine-thiolactone, protein homocysteinylation and oxidative stress in the circulation of patients with Eales’ disease

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