Homocysteine level and risk of different stroke types: A meta-analysis of prospective observational studies

Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study

“…These previous studies suggested that homocysteine was associated with NAFLD progression. Meanwhile, accumulating evidence has demonstrated that homocysteine is an independent risk factor for cardiovascular diseases such as stroke [28, 29] and ischemic heart disease [30, 31], which suggests that homocysteine may mediate the association between NAFLD and cardiovascular diseases [32]. Thus, it is plausible that homocysteine might be an effective target for preventing NAFLD progression and its related cardiovascular complications.…”

Choline and Betaine Intakes Are Not Associated with Cardiovascular Disease Mortality Risk in Japanese Men and Women

“…Several studies have found betaine to be a determinant for homocysteine concentration (2, 3, 6). Metaanalyses have shown that high homocysteine concentration is associated with the risk of coronary heart disease (7) and ischemic stroke (8). Although it is still unclear whether these relations are causal (43), it has been postulated that homocysteine may increase abnormal platelet activity and blood coagulation, which lead to thrombotic disorders (44).…”

“…Some studies have also shown that dietary intakes of betaine and choline were inversely associated with inflammatory markers, such as C-reactive protein, IL-6, and TNF-a [reviewed by Rajaie and Esmaillzadeh (6)]. High concentrations of homocysteine are associated with an increased risk of cardiovascular disease, such as stroke and coronary heart disease (7,8). Inflammation plays a role in atherogenesis (9).…”

Does genistein lower plasma lipids and homocysteine levels in postmenopausal women? A meta-analysis

“…Along with changes in lipid profiles, circulating levels of homocysteine are significantly higher in postmenopausal women than in premenopausal women 9 . Since high levels of homocysteine contribute to the pathogenesis of ischemic stroke by causing atherogenesis through endothelial damage and coagulation abnormalities 10,11 , the elevated homocysteine level is considered as an independent risk factor for CVD in postmenopausal women 12,13 . Therefore, both changes in lipid metabolism and homocysteine levels should be emphasized in studies of effective prevention and treatment strategies for CVD in postmenopausal women.…”