Homogeneous near-infrared emissive polymeric nanoparticles based on amphiphilic diblock copolymers with perylene diimide and PEG pendants: self-assembly behavior and cellular imaging application

Yáng, Zhèn; Yuan, Yan; Jiang, Rongcui; Fu, Nina; Lü, Xiaomei; Tian, Congcong; Hu, Wenbo; Fan, Quli; Huang, Wei

doi:10.1039/c3py01197f

Cited by 46 publications

(44 citation statements)

References 36 publications

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“…During recent years, there has been an increasing interest in the development of rylene bisimidecontaining nanoparticles using amphiphilic block copolymers, by which coreeshell type nanoparticles could be obtained by the selfassembly in selective solvents [22,27]. An example involves the synthesis of self-assembled polymeric nanoparticles based on amphiphilic diblock copolymers with perylene bisimide, which were synthesized by reversible additionefragmentation chain transfer (RAFT) polymerization of perylene bisimide acrylate [27].…”

Section: Introductionmentioning

confidence: 99%

Rylene bisimide-based nanoparticles with cross-linked core and thermoresponsive shell using poly(vinyl amine)-based block copolymers

Nakabayashi

Noda

Watanabe

et al. 2015

Polymer

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Section: Introductionmentioning

confidence: 99%

Rylene bisimide-based nanoparticles with cross-linked core and thermoresponsive shell using poly(vinyl amine)-based block copolymers

Nakabayashi

Noda

Watanabe

et al. 2015

Polymer

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“…33,34 Therefore, the size distribution of PEG-IM-PhNH 2 FPNs has been determined in PBS to confirm the particles sizes. The results showed that the size distribution of PEG-IM-PhNH 2 FPNs was 98 ± 2 nm, with a polydispersity index of 0.209 ( Figure 3A).…”

Section: Resultsmentioning

confidence: 99%

Facile Preparation of Biocompatible and Robust Fluorescent Polymeric Nanoparticles via PEGylation and Cross-Linking

Zhang

et al. 2015

ACS Appl. Mater. Interfaces

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Novel cross-linked copolymers of PEG-IM-PhNH2 are successfully synthesized through PEGylation via radical polymerization of 2-isocyanatoethyl methacrylate and poly(ethylene glycol) monomethyl ether methacylate and subsequent cross-linking with an amino-terminated aggregation-induced emission fluorogen. Such obtained amphiphilic copolymers can self-assemble to form uniform fluorescent polymeric nanoparticles (FPNs) and be utilized for cell imaging. These cross-linked FPNs are demonstrated good water dispersibility with ultralow critical micelle concentration (∼ 0.002 mg mL(-1)), uniform morphology (98 ± 2 nm), high red fluorescence quantum yield, and excellent biocompatibility. More importantly, this novel strategy of fabricating cross-linked FPNs paves the way to the future development of more robust and biocompatible fluorescent bioprobes.

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“…[63] It was not the case for the copolymer 12, when the 1 H-nMr spectrum was registered in D 2 O (Figure S9(C)). as water is a poor solvent for the conjugated main chain, other phenomenon should play a role in its water dispersion.…”

Section: (A)]mentioning

confidence: 99%

Synthesis and self-assembly of fluorene-vinylene alternating copolymers in “Hairy-Rod” architecture: side chain – mediated tuning of conformation, microstructure and photophysical properties

Colak

Cianga

Cianga³

et al. 2016

Designed Monomers and Polymers

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In the present work, we demonstrate that the side chain choice, as a tunable parameter, is an effective strategy to drive molecular ordering, packing motifs and overall microstructure of a conjugated polymer. By applying Wittig polycondensation novel 'rod-coil' structures, in 'hairy-rod' architecture, based on fluorenylene vinylene copolymers with well-defined oligomeric side chains were synthesized using 'T'-shaped or 'Cross'-shaped p-terphenyl macromonomers. The overall character of the copolymers was systematically varied by attaching of hydrophilic PEG 2000, hydrophobic polar oligo-ε-caprolactone or hydrophobic and non-polar oligostyrene side chains. Self-assembling of the copolymers by simple direct dissolution method was achieved in various solvents by modifying their selectivity in relation to the side chain or main chain. The morphology investigations demonstrated that unique nanofeatures obtained in each case (helical foldamers, vesicles, disks, or helical turns) depend on the nature, number, and position of the side chains which influence the photophysical properties. The 'hairy-rod' topology is also responsible for the selfassembly of the materials in molten state, as thermal analysis revealed, and the propensity of the new synthesized conjugated main chain for helical folding was evidenced, as well.

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Homogeneous near-infrared emissive polymeric nanoparticles based on amphiphilic diblock copolymers with perylene diimide and PEG pendants: self-assembly behavior and cellular imaging application

Cited by 46 publications

References 36 publications

Rylene bisimide-based nanoparticles with cross-linked core and thermoresponsive shell using poly(vinyl amine)-based block copolymers

Rylene bisimide-based nanoparticles with cross-linked core and thermoresponsive shell using poly(vinyl amine)-based block copolymers

Facile Preparation of Biocompatible and Robust Fluorescent Polymeric Nanoparticles via PEGylation and Cross-Linking

Synthesis and self-assembly of fluorene-vinylene alternating copolymers in “Hairy-Rod” architecture: side chain – mediated tuning of conformation, microstructure and photophysical properties

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