Homologous Type of Malignant Mixed Mullerian Tumor of the Uterus Presenting as a Cervical Mass

Kuyumcuoğlu, Umur; Kale, Ahmet

doi:10.1016/s1726-4901(09)70423-x

Cited by 21 publications

(17 citation statements)

References 5 publications

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“…In most cases women are in post-menopause, especially between the 6th and the 7th decade [3] . Risk factors are similar to those of endometrial cancer, including nulliparity, obesity, advanced age, exposure to exogenous oestrogens, pelvic irradiation, and long-term use of tamoxifen [4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

Malignant Mixed Müllerian Tumour of the Uterus: Analysis of 44 Cases

et al. 2017

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Objectives: The aim of our study was to evaluate the clinicopathological features and prognostic factors of uterine carcinosarcoma. Patients and Methods: In this retrospective study, the clinical characteristics of 44 patients with uterine MMMT were evaluated. Survival curves were estimated by the Kaplan-Meier method and compared by the log-rank test. Results: Forty-four patients with uterine carcinosarcoma were referred to our unit between 1995 and 2015. Their median age was 66.5 years. All women underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. Twenty-five percent had omental resection. Pelvic lymphadenectomy was performed in 18.2% of the cases. Twenty-six of the patients presented with stage I/II disease, 17 with advanced stages. In 20.5% of the cases there were metastases at diagnosis. Forty women received adjuvant chemotherapy, with complete remission in 67.9% of the cases. Recurrences were observed in 27.3% of the women. Disease-free and overall survival was 27 and 103 months, respectively. The FIGO stage, histological type, tumour size, chemotherapy regimen, pelvic lymphadenectomy, and myometrial invasion did not affect survival. Conclusions: Uterine MMMT is an aggressive tumour, often diagnosed at an advanced stage and with a high rate of metastases or recurrences. Because of its rarity, its management is controversial and fixed prognostic factors cannot be defined.

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Section: Introductionmentioning

confidence: 99%

Malignant Mixed Müllerian Tumour of the Uterus: Analysis of 44 Cases

et al. 2017

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“…It can also originate in the vagina, ovary, uterine cervix or female peritoneum, but these forms are even rarer [6,13,14,15,16]. With regard to their aggressiveness and malignancy, MMMTs are located at one end of the spectrum of mixed Müllerian tumors, i.e.…”

Section: Discussionmentioning

confidence: 99%

Malignant Mixed Müllerian Tumor with an Extensive Squamous-Cell Carcinomatous Component: A Potential Pitfall in Liquid-Based Cervical Cytology

Bongiovanni

Vitale²,

Grassi³

et al. 2014

Acta Cytologica

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Background: Malignant mixed Müllerian tumors (MMMTs) are aggressive tumors arising in the female lower genital tract and characterized by the presence of both a malignant epithelial and a mesenchymal component. Here, we report a case of an MMMT of the uterine corpus with an extensive squamous-cell carcinomatous component processed by liquid-based cytology (LBC). Case Report: An 84-year-old woman with a prior history of anal squamous-cell carcinoma, who complained of vaginal bleeding, was discovered to have a mass protruding from the uterine cervix. A Papanicolaou (Pap) test was performed and the LBC (ThinPrep) preparation showed a background of neutrophils and cellular debris. Atypical cells were identified that presented with hyperchromatic nuclei, nuclear membrane irregularities, multinucleation and abundant cytoplasm with focal keratinization. Scattered nucleolated malignant elements were also identified. The cytological diagnosis resulted in ‘suspicious for squamous-cell carcinoma', favoring primary cervical carcinoma rather than extracervical (anal) carcinoma. The histological examination showed that it was an MMMT with an extensive squamous-cell carcinomatous component. Conclusion: This case illustrates the potential diagnostic pitfall of MMMTs with extensive squamous-cell carcinomatous components in LBC Pap smears. Cytopathologists should keep in mind this diagnostic possibility in postmenopausal women who experience vaginal bleeding or spotting.

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“…6,7 Carcinosarcomas of the vulva Carcinosarcoma represents a rare mixed mesodermal tumor called malignant mixed Mullerian tumor (MMMT). 8,9 It is characterized by a dual component both of sarcoma and carcinoma: carcinoma elements are usually glandular, while the sarcomatous element may resemble normal stroma (homologous or so-called carcinosarcoma). 10 It is found more commonly in the digestive system, liver, and urinary tract, but the most common location is the reproductive system -mainly the uterus and ovaries, and only extremely rarely in the vulva.…”

Section: Introductionmentioning

confidence: 99%

“…8 Due to its aggressive nature and infiltrative growth, initial presentation as a non-specific tumor mass in the uterus is possible. 9 Mullerian adenosarcoma is described as a variant of MMMT of the uterus, normally composed of benign but sometimes mildly atypical glandular epithelial elements admixed with malignant sarcomatous stroma. 11 There are reports in elderly patients (aged 50-60 years).…”

Section: Introductionmentioning

confidence: 99%

“…11 There are reports in elderly patients (aged 50-60 years). 9 It can present clinically as a polyp, with endophytic or exophytic growth in the vulva and vagina, accompanied by metrorrhagia. 11,12 Mixed histological findings can be discernedintermixtures of carcinomatous or adenocarcinomatous with sarcomatous elements, which may include osteosarcoma, chondrosarcoma, and leiomyosarcoma.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2

Chokoeva¹,

Tchernev

Cardoso

et al. 2015

Int J Immunopathol Pharmacol

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Malignant tumors of the female reproductive system are a serious health and social problem, as they are the second most common cause of death among women, after breast cancer. Vulvar tumors represent only 4% of all gynecological neoplasms, and they are fourth in frequency after tumors of the cervix, uterus, and ovary. Ninety-eight percent of all vulvar tumors are benign and only 2% are malignant. Sarcomas of the vulva comprise approximately 1-3% of all vulvar cancers. They are characterized by rapid growth, high metastatic potential, frequent recurrences, aggressive behavior, and high mortality rate. In Part 1 of this paper, we presented the most common forms of sarcoma of the vulva: leiomyosarcoma, epithelioid sarcoma, malignant rhabdoid tumor, and rhabdomyosarcoma. The second part of this review will focus mainly on the rarest variants of vulvar sarcoma: low-grade fibromyxoid sarcoma, synovial sarcoma, monophasic synovial sarcoma, carcinosarcoma, Ewing sarcoma, myeloid sarcoma, dermatofibrosarcoma protuberans, malignant fibrous histiocytoma, angiomatoid fibrous histiocytoma, liposarcoma, malignant peripheral nerve sheath tumor, and malignant mesothelioma.

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Homologous Type of Malignant Mixed Mullerian Tumor of the Uterus Presenting as a Cervical Mass

Cited by 21 publications

References 5 publications

Malignant Mixed Müllerian Tumour of the Uterus: Analysis of 44 Cases

Malignant Mixed Müllerian Tumour of the Uterus: Analysis of 44 Cases

Malignant Mixed Müllerian Tumor with an Extensive Squamous-Cell Carcinomatous Component: A Potential Pitfall in Liquid-Based Cervical Cytology

Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 2

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