Honey has a protective effect against chlorpyrifos-induced toxicity on lipid peroxidation, diagnostic markers and hepatic histoarchitecture

Tanvir, E. M.; Afroz, Rizwana; Chowdhury, M. A. Z.; Khalil, Md. Ibrahim; Hossain, Md. Sabir; Rahman, Md. Abdur; Rashid, MH; Gan, Siew Hua

doi:10.1016/j.eujim.2015.04.004

Cited by 42 publications

(59 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In animal models, honey administration reduced blood urea nitrogen, serum creatinine, AST, and ALT in healthy sheep and showed hepatoprotective effects against carbon tetrachloride-induced liver injury [47]. A recent study by Tanvir et al [48] showed that honey supplementation can ameliorate chlorpyrifos-induced renal and liver toxicities in rats, which was mainly attributed to the antioxidant properties of the honey. The hepatoprotective effects of Tualang honey were previously observed in streptozotocin- (STZ-) induced diabetic rats [33].…”

Section: Discussionmentioning

confidence: 99%

Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Tang

Salam

Jaafar

et al. 2017

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stress-mediated cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats. The rats were orally treated with distilled water (2 mL/kg/day), Tualang honey (1.0 g/kg/day), or ubiquinol (0.2 g/kg/day) throughout the experimental period. Two weeks after the respective treatments, the rats were injected intraperitoneally with saline (1 mL/kg/week) or PQ (10 mg/kg/week) once per week for four consecutive weeks. After four weekly exposures to PQ, the glutathione peroxidase activity and the number of tyrosine-hydroxylase immunopositive neurons in the midbrain were significantly decreased in animals from group PQ (p < 0.05). The lungs of animals from group PQ showed significantly decreased activity of superoxide dismutase and glutathione-S-transferase. Treatment with Tualang honey ameliorated the toxic effects observed in the midbrain and lungs. The beneficial effects of Tualang honey were comparable to those of ubiquinol, which was used as a positive control. These findings suggest that treatment with Tualang honey may protect against PQ-induced toxicity in the rat midbrain and lung.

show abstract

Section: Discussionmentioning

confidence: 99%

Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Tang

Salam

Jaafar

et al. 2017

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

show abstract

“…In our study, supplementation with propolis extract restored the TB and TP levels, indicating the role of propolis in liver protection. It is plausible that the antioxidants present in the ethanolic extract of propolis (Tanvir et al, ) conferred protection of the liver by preserving the membrane integrity (Tanvir, Afroz, Chowdhury, et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, necrotic damage of the hepatocytes causes an increased release of cholesterols from cells into the blood circulation (Santhosh et al, ). The blockage of the bile duct and subsequent decreased secretion of cholesterol into the duodenum may also result in higher cholesterol levels in the serum (Tanvir, Afroz, Chowdhury, et al, ). The data of the present study corroborated with findings reported by Shabana et al ().…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effects of ethanolic constituents of Bangladeshi propolis against tetracycline‐induced hepatic and renal toxicity in rats

et al. 2019

Self Cite

View full text Add to dashboard Cite

The study reports the phenolic composition of propolis from Bangladesh and its ameliorative effects against tetracycline‐induced hepatonephrotoxicity in rats. Male Wistar Albino rats (n = 18) were randomly divided into three following groups: (1) normal control, (2) tetracycline‐treatment (200 mg kg−1 rat−1), and (3) tetracycline (200 mg kg−1 rat−1) + propolis (100 mg kg−1 rat−1) treatments. The ethanolic extract of propolis contained major phenolic acids as well as a flavonoid, rutin. Oral exposure to tetracycline caused severe hepatic and renal damage as indicated by significant alterations in liver marker enzymes in rat serum: bilirubin and protein concentrations, lipid profile, and markers of kidney function when compared with controls. The observed biochemical perturbations were accompanied by histopathological changes. Co‐administration with propolis extract, however, prevented the changes in biochemical parameters, as revealed by maintenance of cell membrane integrity and regulation of lipid profile and the conservation of the histoarchitecture. Practical applications Propolis is a resinous honeybee product which is becoming increasingly popular due to its potential contributions to human health. The phenolic compounds identified in propolis from Bangladesh were effective against tetracycline‐induced hepatic and renal toxicity. Propolis may be a promising natural product in reducing the effects of chronic liver and kidney damage.

show abstract

“…Increased activities of ALT, AST, GGT, ALP, and LDH in the serum are utilized to determine hepatic dysfunction and are directly implicated in the extent of hepatic damage and toxicity [33, 34]. ALT is a hepatocyte cytoplasmic enzyme, and ALP is mostly synthesized by liver.…”

Section: Discussionmentioning

confidence: 99%

“…The rise in the TB level is an important clinical indicator for the severity of necrosis, whereas its accumulation is the measure of the binding, conjugation, and excretory capacity of the hepatic cells [38]. In addition, serum TP and albumin levels can provide information about the severity of the necrosis and the capacity for protein synthesis [34]. In this study, there were no significant differences in the levels of TB, TP, ALB, GLB, or albumin or the globulin (A/G) ratio among the treatment groups.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats

Paul

Ali

Rumpa

et al. 2017

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

This study was undertaken to investigate the toxicological profile of a methanolic extract of Garcinia pedunculata fruit in rats by conducting hematological, biochemical, and histopathological examinations. Long Evans rats were divided into four groups, each with 6 animals, and were treated with three oral doses (250, 500, and 1000 mg/kg) once daily for 21 days. The extract did not cause significant changes in body and relative organ weight, percent water content, or hematological parameters at any administered doses. However, a significant dose-dependent positive effect in serum lipid profile and all atherogenic indices including the cardiac risk ratio, Castelli's risk index-2, and the atherogenic coefficient were observed. Significant increases in the levels of iron and decreases in serum alkaline phosphatase, alanine transaminase, and lactate dehydrogenase activities and the levels of serum glucose were noted when the extract was administered at the highest dose (1000 mg/kg). Histopathological examination of the target tissues further confirmed that the extract was safe and had no observed toxicological features. Our study indicates that G. pedunculata fruit is nontoxic, has the potential to be effective against atherosclerosis, and may be used as a hepatoprotectant. The fruit extract is also beneficial to those with iron deficiency and hyperglycemia.

show abstract

Honey has a protective effect against chlorpyrifos-induced toxicity on lipid peroxidation, diagnostic markers and hepatic histoarchitecture

Cited by 42 publications

References 50 publications

Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Ameliorative effects of ethanolic constituents of Bangladeshi propolis against tetracycline‐induced hepatic and renal toxicity in rats

Assessment of Toxicity and Beneficiary Effects of Garcinia pedunculata on the Hematological, Biochemical, and Histological Homeostasis in Rats

Contact Info

Product

Resources

About