Human action recognition, also known as HAR, is at the foundation of many different applications related to behavioral analysis, surveillance, and safety, thus it has been a very active research area in the last years. The release of inexpensive RGB-D sensors fostered researchers working in this field because depth data simplify the processing of visual data that could be otherwise difficult using classic RGB devices. Furthermore, the availability of depth data allows to implement solutions that are unobtrusive and privacy preserving with respect to classic video-based analysis. In this scenario, the aim of this chapter is to review the most salient techniques for HAR based on depth signal processing, providing some details on a specific method based on temporal pyramid of key poses, evaluated on the well-known MSR Action3D dataset.