Hormonal Regulation of Cell Cycle Progression and its Role in Development

John, Peter

doi:10.1002/9780470988923.ch14

Cited by 8 publications

(3 citation statements)

References 120 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, signals that act across cell boundaries appear most likely to define the areas of division and the limits of elongation. Such signals could include mobile molecules such as hormone, RNA, or protein signals (for review, see John, 2007). Consistent with this, normal planar dimensions of the leaf lamina were established while contiguity of epidermal and palisade cells extended to the leaf margins, perhaps allowing a cytokinin gradient (Nishimura et al, 2004).…”

Section: Discussionmentioning

confidence: 83%

“…Similar division follows after cells are first enlarged by the EXPANSIN cell wall enzyme (Pien et al, 2001). In the establishment of new foci of growth, therefore, cell division may be a secondary event (for review, see John, 2007); however, the importance of cell-autonomous developmental programs in directing ongoing growth has not been resolved (Kaplan and Hagemann, 1991;Ishikawa and Evans, 1995;Baluska et al, 1996;Fleming, 2006). For example, change in cell size is frequently noted in mesophyll cells when genetic changes reduce cell number and result in larger cell size (Hemerly et al, 1995) or increase cell number and reduce cell size (Dewitte et al, 2003), and this can be interpreted to indicate modified cell-autonomous controls that increase or decrease cell volume in compensation to stabilize leaf size (Tsukaya, 2006), although it could result from determinate organ size interrupting expansion in different cell numbers.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Expression of Genomic AtCYCD2;1 in Arabidopsis Induces Cell Division at Smaller Cell Sizes: Implications for the Control of Plant Growth

John

2007

Plant Physiol.

View full text Add to dashboard Cite

The Arabidopsis (Arabidopsis thaliana) CYCD2;1 gene introduced in genomic form increased cell formation in the Arabidopsis root apex and leaf, while generating full-length mRNA, raised CDK/CYCLIN enzyme activity, reduced G1-phase duration, and reduced size of cells at S phase and division. Other cell cycle genes, CDKA;1, CYCLIN B;1, and the cDNA form of CYCD2;1 that produced an aberrantly spliced mRNA, produced smaller or zero increases in CDK/CYCLIN activity and did not increase the number of cells formed. Plants with a homozygous single insert of genomic CYCD2;1 grew with normal morphology and without accelerated growth of root or shoot, not providing evidence that cell formation or CYCLIN D2 controls growth of postembryonic vegetative tissues. At the root apex, cells progressed normally from meristem to elongation, but their smaller size enclosed less growth and a 40% reduction in final size of epidermal and cortical cells was seen. Smaller elongated cell size inhibited endoreduplication, indicating a cell size requirement. Leaf cells were also smaller and more numerous during proliferation and epidermal pavement and palisade cells attained 59% and 69% of controls, whereas laminas reached normal size.

show abstract

Section: Discussionmentioning

confidence: 83%

mentioning

confidence: 99%

Expression of Genomic AtCYCD2;1 in Arabidopsis Induces Cell Division at Smaller Cell Sizes: Implications for the Control of Plant Growth

John

2007

Plant Physiol.

View full text Add to dashboard Cite

show abstract

“…Physiological roles of auxin in promoting cell proliferation have been extensively studied in various plant species but surprisingly little is established about the molecular mechanisms underlying these responses. For example, the application of exogenous auxin promotes the expression of many cell cycle genes (John, 2007), but it is not known whether some members of the AUX/IAA-ARF transcription factors directly control their expression in response to auxin. Previous studies have shown that auxin is also involved in regulating the stability of E2F proteins (del Pozo et al, 2002;Magyar et al, 2005), which suggests that part of the auxin-dependent cell cycle control might rely on their post-transcriptional modification.…”

Section: Auxin Mediates the Mitotic-to-endocycle Transitionmentioning

confidence: 99%

Auxin modulates the transition from the mitotic cycle to the endocycle in Arabidopsis

et al. 2010

View full text Add to dashboard Cite

SUMMARYAmplification of genomic DNA by endoreduplication often marks the initiation of cell differentiation in animals and plants. The transition from mitotic cycles to endocycles should be developmentally programmed but how this process is regulated remains largely unknown. We show that the plant growth regulator auxin modulates the switch from mitotic cycles to endocycles in Arabidopsis; high levels of TIR1-AUX/IAA-ARF-dependent auxin signalling are required to repress endocycles, thus maintaining cells in mitotic cycles. By contrast, lower levels of TIR1-AUX/IAA-ARF-dependent auxin signalling trigger an exit from mitotic cycles and an entry into endocycles. Our data further demonstrate that this auxin-mediated modulation of the mitotic-to-endocycle switch is tightly coupled with the developmental transition from cell proliferation to cell differentiation in the Arabidopsis root meristem. The transient reduction of auxin signalling by an auxin antagonist PEO-IAA rapidly downregulates the expression of several core cell cycle genes, and we show that overexpressing one of the genes, CYCLIN A2;3 (CYCA2;3), partially suppresses an early initiation of cell differentiation induced by PEO-IAA. Taken together, these results suggest that auxin-mediated mitotic-to-endocycle transition might be part of the developmental programmes that balance cell proliferation and cell differentiation in the Arabidopsis root meristem.

show abstract

Auxin and Its Role in Plant Development

Zažímalová¹,

Petrášek²,

Benková³

2014

View full text Add to dashboard Cite

Hormonal Regulation of Cell Cycle Progression and its Role in Development

Cited by 8 publications

References 120 publications

Expression of Genomic AtCYCD2;1 in Arabidopsis Induces Cell Division at Smaller Cell Sizes: Implications for the Control of Plant Growth

Expression of Genomic AtCYCD2;1 in Arabidopsis Induces Cell Division at Smaller Cell Sizes: Implications for the Control of Plant Growth

Auxin modulates the transition from the mitotic cycle to the endocycle in Arabidopsis

Auxin and Its Role in Plant Development

Contact Info

Product

Resources

About