Hormonal Specificity in the Suppression of Sexual Receptivity of the Female Golden Hamster

Coniglio, Linda P.; Paup, Donald C.; Clemens, Lynwood G.

doi:10.1677/joe.0.0570055

Cited by 22 publications

(9 citation statements)

References 12 publications

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“…In addition, estradiol treatment following prepubertal OVX also defeminizes adult behavior, indicating that estradiol is the ovarian hormone driving behavioral defeminization during adolescence (Schulz & Sisk, 2006). While it may be surprising that ovarian hormones defeminize female lordosis behavior during adolescence, estrogen-receptor mediated behavioral defeminization also occurs during the perinatal period of development (Clemens & Gladue, 1978; Coniglio, Paup, & Clemens, 1973; Paup, Coniglio, & Clemens, 1972; for review see Wallen & Baum, 2002). Whether ovarian hormone-induced defeminization of lordosis behavior during adolescent development negatively impacts female reproductive success is not known.…”

Section: 4 Hormone-dependent Behavioral Organization During Pubertymentioning

confidence: 99%

The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development

Schulz

Sisk

2016

Neuroscience & Biobehavioral Reviews

266

156

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Adolescence is a developmental period characterized by dramatic changes in cognition, risk-taking and social behavior. Although gonadal steroid hormones are well-known mediators of these behaviors in adulthood, the role gonadal steroid hormones play in shaping the adolescent brain and behavioral development has only come to light in recent years. Here we discuss the sex-specific impact of gonadal steroid hormones on the developing adolescent brain. Indeed, the effects of gonadal steroid hormones during adolescence on brain structure and behavioral outcomes differs markedly between the sexes. Research findings suggest that adolescence, like the perinatal period, is a sensitive period for the sex-specific effects of gonadal steroid hormones on brain and behavioral development. Furthermore, evidence from studies on male sexual behavior suggests that adolescence is part of a protracted postnatal sensitive period that begins perinatally and ends following adolescence. As such, the perinatal and peripubertal periods of brain and behavioral organization likely do not represent two discrete sensitive periods, but instead are the consequence of normative developmental timing of gonadal hormone secretions in males and females.

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Section: 4 Hormone-dependent Behavioral Organization During Pubertymentioning

confidence: 99%

The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development

Schulz

Sisk

2016

Neuroscience & Biobehavioral Reviews

266

156

View full text Add to dashboard Cite

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“…While it may seem counterintuitive that ovarian hormones defeminize female lordosis behavior during adolescence, estrogen-receptor mediated behavioral defeminization also occurs during the perinatal period sensitive period (Clemens and Gladue, 1978; Coniglio et al, 1973; Paup et al, 1972; for review see Wallen and Baum, 2002). Whether estradiol-induced defeminization of lordosis behavior during development negatively impacts female reproductive success is not known.…”

Section: Ovarian Hormone Exposure During Adolescence Organizes Femalementioning

confidence: 99%

Back to the future: The organizational–activational hypothesis adapted to puberty and adolescence

Schulz

Molenda-Figueira

Sisk

2009

Hormones and Behavior

520

386

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Phoenix, Goy, Gerall, and Young first proposed in 1959 the organizational-activational hypothesis of hormone-driven sex differences in brain and behavior. The original hypothesis posited that exposure to steroid hormones early in development masculinizes and defeminizes neural circuits, programming behavioral responses to hormones in adulthood. This hypothesis has inspired a multitude of experiments demonstrating that the perinatal period is a time of maximal sensitivity to gonadal steroid hormones. However, recent work from our laboratory and others demonstrates that steroid-dependent organization of behavior also occurs during adolescence, prompting a reassessment of the developmental time-frame within which organizational effects are possible. In addition, we present evidence that adolescence is part of a single protracted postnatal sensitive period for steroid-dependent organization of male mating behavior that begins perinatally and ends in late adolescence. These findings are consistent with the original formulation of the organizational/ activational hypothesis, but extend our notions of what constitutes "early" development considerably. Finally, we present evidence that female behaviors also undergo steroid-dependent organization during adolescence, and that social experience modulates steroid-dependent adolescent brain and behavioral development. The implications for human adolescent development are also discussed, especially with respect to how animal models can help to elucidate the factors underlying the association between pubertal timing and adult psychopathology in humans.The 1959 landmark paper by Phoenix, Goy, Gerall, and Young first posited what became the organizational-activational hypothesis of hormone-driven sex differences in brain and behavior (Phoenix et al., 1959). In this hypothetical framework, a transient rise in testosterone during prenatal or early postnatal development masculinizes and defeminizes neural circuits in males, while the absence of testosterone in females results in development of a feminine neural phenotype. Upon gonadal maturation during puberty, testicular and ovarian hormones act on previously sexually differentiated circuits to facilitate expression of sex-typical behaviors in particular social contexts. Research in the 1960-70s identified a maximally sensitive period for hormone-dependent sexual differentiation that occurs during late prenatal and early neonatal development (reviewed in Baum, 1979;Wallen and Baum, 2002). Thus, the original conception was that steroid hormones organize brain structure during an early developmental sensitive period, and activate behavior during puberty and into adulthood.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the...

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“…Animals treated with norethindrone achieved a significantly higher frequency of mounting than the animals treated with progesterone (Duncan's <0·05). Scores for animals treated with dydrogesterone were not different from those for animals treated with progesterone and the latter were not 272 A. J. Vomachka et al different from controls injected neonatally with sesame oil (Coniglio et al, 1973).…”

Section: Male Behaviourmentioning

confidence: 73%

“…While the hamsters treated with progesterone and dydrogesterone exhibited fewer lordosis responses, their responses were of longer duration. Comparison of lordosis scores of these groups with females given oil injections neonatally and tested under similar conditions (Coniglio et al, 1973) revealed no significant difference between dydrogesterone and control animals. The lordosis duration of the progesterone group, however, was significantly shorter than that of the § io control animals (Duncan's, P<0-05).…”

Section: Female Behaviourmentioning

confidence: 89%

“…Control animals were injected on Days 2, 3 and 4 of life with the vehicle and were tested for all behavioural measures concurrently. While scores from these animals were used for comparison in this study, the results of their tests have been reported in detail elsewhere (Coniglio, Paup & Clemens, 1973). Be¬ havioural testing began 2 to 3 hr after the lights were put off.…”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Progestin-Induced Pseudohermaphroditism in the Female Hamster

VOMACHKA¹,

PAUP²,

CONIGLIO³

et al. 1974

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The synthetic progestins, norethynodrel and norethindrone, given neonatally to female hamsters caused masculinization of the genitalia, increased masculine sexual behaviour in the adults, and reduced spontaneous and hormone-induced female sexual behaviour. Neonatal progesterone treatment did not masculinize female hamsters but diminished hormone-induced feminine behaviour. Dydrogesterone neither masculinized nor defeminized female hamsters.

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Hormonal Specificity in the Suppression of Sexual Receptivity of the Female Golden Hamster

Cited by 22 publications

References 12 publications

The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development

The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development

Back to the future: The organizational–activational hypothesis adapted to puberty and adolescence

Progestin-Induced Pseudohermaphroditism in the Female Hamster

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