Hormonally Induced Renal Neoplasia in the Male Syrian Hamster and the Inhibitory Effect of 2-Bromo-α-ergocryptine Methanesulfonate
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Hamilton, John M.; Flaks, Antonia; Saluja, Pulin; Maguire, S.H.

doi:10.1093/jnci/54.6.1385

Cited by 23 publications

(4 citation statements)

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“…First, the DESinduced proliferation of the Fisher rat mammotroph occurs more rapidly than other pituitary systems. The present data show dramatic effects of CB 154 in a matter of weeks; in contrast, up to 9 months of treatment were required to see effects of CB 154 upon melanotroph proliferation [8]. Sec ond, the proliferative response to DES of the Fisher rat mammotroph is unusually large in comparison with the re sponse of other strains of rat [13,22]: consequently, the dopaminergic attenuation of DES-induced proliferation demonstrated in this communication is more pronounced than the effects of dopaminergic agonists reported previ ously.…”

Section: Discussioncontrasting

confidence: 47%

“…In many vertebrate species, a D-2 dopamine receptor occur ring on the surface of the mammotroph regulates the re lease and synthesis of prolactin [2,6,12]. Acute stimulation of this receptor inhibits prolactin release [2,6]: more pro longed stimulation diminishes the capacity of the mammo troph to synthesize prolactin [14], In view of our recent de monstration that chronic stimulation of the D-2 receptor in the intermediate lobe causes this structure to atrophy and earlier demonstrations suggesting a dopaminergic attenua tion of estrogen-induced proliferation of the pituitary gland, it seemed worthwhile to investigate the effects of 2-bromo-alpha-ergocryptine (CB 154) upon the DES-in duced proliferation of the mammotrophs of the Fisher 344 rat pituitary gland [1,8,9,13]. In this communication, we report that CB 154, a potent D-2 agonist, markedly attenu ated the DES-induced proliferation of the mammotrophs of the male Fisher 344 rat [6].…”

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confidence: 99%

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Dopaminergic Modulation of the Diethylstilbestrol-Induced Proliferation of the Anterior Pituitary Gland of the Fisher 344 Rat

Miyazaki¹,

Kebabian²

1985

Neuroendocrinology

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Bromocriptine (CB 154), a potent agonist upon the D-2 receptor, blocks the proliferation of the mammotrophs and the elevation of serum prolactin concentration induced by chronic exposure of male Fisher 344 rats to diethylstilbestrol (DES). Fluphenazine, a dopamine receptor antagonist, blocks these effects of CB 154. We conclude that a D-2 receptor occurs on the proliferating mammotroph of the male Fisher 344 rat and that stimulation of this receptor inhibits prolactin release and stops the DES-induced proliferation of these cells.

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Section: Discussioncontrasting

confidence: 47%

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confidence: 99%

Dopaminergic Modulation of the Diethylstilbestrol-Induced Proliferation of the Anterior Pituitary Gland of the Fisher 344 Rat

Miyazaki¹,

Kebabian²

1985

Neuroendocrinology

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“…NP and some of its derivatives are excreted by the kidney (Drotman, 1980;Knaak et al, 1966) which may deliver a significant dose to the target site, potentially from both blood and urine. Kidney in humans (Concolino et al, 1993) and experimental animals have estrogen receptors (Hamilton et al, 1975;Li and Li, 1996). An estrogen receptor-mediated effect on tubular epithelial cell proliferation has been proposed as a potential cause of acquired cystic kidney disease (Concolino et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

Polycystic Kidney Disease Induced in F1 Sprague-Dawley Rats Fed para-Nonylphenol in a Soy-Free, Casein-Containing Diet

Latendresse

Newbold²,

Weis³

et al. 2001

Toxicological Sciences

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para-Nonylphenol (NP; CAS #84852-15-3), an alkylphenol with a 9-carbon olefin side chain, is widely used in the manufacture of nonionic surfactants, lubricant additives, polymer stabilizers, and antioxidants. Due to its wide commercial use and putative endocrine activity in humans and wildlife, the NTP elected to assess its effects on reproduction in multigenerational studies. To avoid known estrogenic activity of phytoestrogens in soy and alfalfa, a soy- and alfalfa-free, casein-containing diet was used in a range-finding study to determine the doses of NP to be tested further. NP was administered to Sprague-Dawley rats in the diet at 0, 5, 25, 200, 500, 1000, or 2000 ppm to F(0) dams beginning on gestation-day 7. The F(1) pups were weaned at postnatal day (PND) 21, and their exposure via diet was continued at the same dose level as their respective dams. Pup weights from birth through weaning were not significantly different from controls in any dose group, but the average weight of both sexes was significantly less compared to controls, beginning with the PND 28 weighing. The F(1) rats were sacrificed on PND 50 (n = 15, 3 pups of each sex from 5 litters for all dose groups). Terminal body weights of males and females in the 2000-ppm dose group were 74% and 85% of controls, respectively. Severe polycystic kidney disease (PKD) was present in 100% of the 2000 ppm-exposed male and female rats. At 1000 ppm, 67% of males and 53% of females had mild to moderate PKD versus none of either sex in the control and lower-dose groups. The no-adverse-effect level (NOAEL) for PKD was determined to be 500 ppm. Previous studies with comparable duration and route of exposure, but using soy-containing diets, reported either no or only mild PKD at 2000 ppm NP. We conclude that the renal toxicity of NP is highly dependent on the diet on which the animals are maintained. The potential interaction of diet and test compounds on nonreproductive as well as reproductive endpoints should be considered when contemplating the use of special diets formulated to minimize exogenous "hormone" content for the study of the effects of putative endocrine disruptive chemicals.

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“…This kind of tumor of the intermediate lobe was graded as benign and classified as melanotroph adenoma . Neoplastic transformation of the intermediate lobe has been previously reported in the Syrian hamster exposed to estrogens (Hamilton et al 1975;Saluja et al 1979) and is accompanied by elevated serum α-MSH concentration (Kurl et al 1990). ER mRNA has been demonstrated by in situ hybridization in the intermediate lobe of rodents (Pelletier et al 1988;Stefaneanu et al 1994) and protracted estrogen treatment can also lead to the development of intermediate lobe tumors in some strains of rats.…”

Section: Discussionmentioning

confidence: 91%

Immunohistochemistry of the golden hamster pituitary during chronic administration of diethylstilbestrol: a quantitative analysis using confocal laser scanning microscopy

Cauwenberge

Nonclercq

Laurent

et al. 2001

Histochem Cell Biol

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The aim of this study was to examine by immunohistochemistry the morphologic changes affecting pituitary cell populations in male Syrian hamsters undergoing chronic exposure (3 days to 9 months) to diethylstilbestrol (DES). Cell proliferation in the hypophysis was monitored by the immunohistochemical demonstration of S-phase cells after pulse labeling with 5-bromo-2′-deoxyuridine. Cell proliferation analysis was combined with the identification of different cell populations by immunostaining with antisera raised against hypophyseal hormones. Sections processed for double-label immunofluorescence were examined by confocal microscopy. In the adenohypophysis, the relative surface occupied by gonadotrophs and thyrotrophs decreased rapidly during the first months of treatment while corticotroph and somatotroph populations remained unaffected. Accordingly, the incidence of S-phase cells in these four cell populations was lower than or similar to control values. In contrast, lactotrophs increased gradually during the first month of exposure to DES to reach a maximum value at 2-4 months. At the beginning, this increase was primarily due to hyperplasia but later on it also involved cellular hypertrophy. Somatomammotrophs did not seem to be involved in this model. In the pars intermedia, the labeling index of melanotrophs rose rapidly to reach values 5-6 times higher than controls. After 4 months, neoplasms originating from the pars intermedia were seen invading both the neuro-and the adenohypophysis. At the end of treatment, the pituitary was markedly enlarged resulting from the development of an adenoma of the pars intermedia.

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Hormonally Induced Renal Neoplasia in the Male Syrian Hamster and the Inhibitory Effect of 2-Bromo-α-ergocryptine Methanesulfonate 2

Cited by 23 publications

References 0 publications

Dopaminergic Modulation of the Diethylstilbestrol-Induced Proliferation of the Anterior Pituitary Gland of the Fisher 344 Rat

Dopaminergic Modulation of the Diethylstilbestrol-Induced Proliferation of the Anterior Pituitary Gland of the Fisher 344 Rat

Polycystic Kidney Disease Induced in F1 Sprague-Dawley Rats Fed para-Nonylphenol in a Soy-Free, Casein-Containing Diet

Immunohistochemistry of the golden hamster pituitary during chronic administration of diethylstilbestrol: a quantitative analysis using confocal laser scanning microscopy

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