Hormones and Calcium Metabolism

Effect of Cortisone on the Intestinal Absorption of Calcium in Rats

“…In some clinical investigations, the faecal calcium excretion has increased following steroid ad ministration and these results were interpreted as deterioration of the calcium absorption [1,3,11,17,23]. However, other authors could not confirm this observation [4,21], Our present experiments are concerned with the effect of long term cortisone treatment on intestinal calcium absorption in vivo in rats fed a normal diet and in animals kept on calcium deficient diet. Calcium deprivation in diet has been described as causing a significant increase in calcium absorption [14,19,20].…”

“…In vivo in dogs [8], rabbits [27] and chickens [21,22,31] the cortisone given in large doses reduced the calcium absorption. On the other hand, Clark et al could not detect any change in cal cium absorption in rats after cortisone treatment lasting three days (3 mg/die) [6,7], Stoerk et al [24,25] observed that de creased calcium absorption and concomittant hypocalcaemia in rats following hydrocortisone treatment only developed after pre-…”

The Influence of Hormonal Treatment and Orchiectomy, Oophorectomy and Thyroidectomy on Experimental Fractures: A Quantitative P32-Autoradiographic, Roentgenologic and Tissue-Analytic Study

“…If the present results are evaluated from a general point of view, it must he noted that no claim of their general validity can be made without further consideration, nor is it safe to extrapolate from them directly to the effects of endocrines in human bone repair. However, it has been clearly demonstrated that these hormones, which one has not considered to possess targets with obvious bearing on bone (27,28), as exemplified particularly by androgen with its effect on the nitrogen balance, exert an influence which enables the biological phenomenon involved in bone repair to be controlled to a certain extent. Further research may be able to show the value of these agents as aids in the treatment of certain kinds of cases in which it is desired to simulate the regeneration of bone.…”

In Vitro Biosynthesis of Calcitonin

“…Then, the physiological regulation of blood calcium would be mediated mainly by those factors that influence the formation and resorption of bone, namely parathyroid hormone, calcitonin, and vitamin D. But there are other factors which have been implicated in the control of bone metabol1.sm and plasma calcium._ Thyroxine, corticoids:. estrogens and growth hormone affect bone resorption, blood and urine calcium and phosphate (Nordin, 1966). The titers of these hormones do not change with experimentally induced changes in plasma calcium.…”