2015
DOI: 10.1016/j.expthermflusci.2015.04.020
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Horse and dog blood flows in PDMS rectangular microchannels: Experimental characterization of the plasma layer under different flow conditions

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Cited by 13 publications
(12 citation statements)
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“…In this evaluation, s.d. map is used to distinguish the RBC-rich regions [37]. Pixels in the RBC-rich regions have high s.d.…”
Section: Identification Of Cell-free Layermentioning
confidence: 99%
“…In this evaluation, s.d. map is used to distinguish the RBC-rich regions [37]. Pixels in the RBC-rich regions have high s.d.…”
Section: Identification Of Cell-free Layermentioning
confidence: 99%
“…The PDMS microchannel network was placed on the stage of the inverted microscope where a syringe pump (PHD ULTRA, Harvard Apparatus) was used to control the flow rate (1 μL/min) of the working fluids. performed in straight microvessels (Tateishi et al 1994;Kim et al 2006Kim et al , 2009Dietzel et al 2014;Namgung et al 2014), in microchannels with simple geometries Garcia & Lima 2012;Sampaio et al 2015) and microfluidic devices with artificial geometries to perform blood plasma and cells separation (Pinho et al 2013;Rodrigues et al 2015;Tripathi et al 2015). Overall, those studies have found that the CFL always forms around the walls and its thickness depends mainly on the haematocrit, size and geometry of the vessel or microchannel.…”
Section: Experimental Set-upmentioning
confidence: 99%
“…Therefore, the progress of the high-speed video microscopy systems has yielded valuable information on several blood flow phenomena happening in microcirculation. The cell-free layer (CFL) is a well-known physiological phenomenon that was studied both in vivo (Tateishi et al 1994;Kim et al 2006Kim et al , 2009Ong et al 2012;Dietzel et al 2014;Namgung et al 2014) and in vitro Fedosov et al 2010;Garcia & Lima 2012;Pinho et al 2013;Rodrigues et al 2015;Sampaio et al 2015). Briefly, the formation of a CFL or a cell-depleted layer is mainly attributed to the RBCs axial migration towards the centre of the microchannel and consequently leading to the formation of two phase flows, i.e.…”
Section: Introductionmentioning
confidence: 99%
“…These microscale hemodynamic phenomena play an important role in blood mass transport mechanisms [3,11]. The CFL thickness depends of several factors such as cell concentration, deformability, vessel diameter, cell aggregation, flow rate, presence of microbubbles and geometry of the microchannels [12][13][14][15][16][17][18][19][20]. For instance, by increasing the concentration of RBCs, i.e., increasing the hematocrit (Hct), there is a decrease of CFL thickness [17,21].The bifurcations are geometries extremely common in both microvessels and microfluidic devices and it is important to improve our current understanding regarding the influence of the bifurcations and confluences on the blood flow behavior at a microscale level.…”
mentioning
confidence: 99%