Hospital wastewaters: A reservoir and source of clinically relevant bacteria and antibiotic resistant genes dissemination in urban river under tropical conditions

Salah, Dhafer Mohammed M. Al; Ngweme, Georgette N.; Laffite, Amandine; Otamonga, Jean‐Paul; Mulaji, Crispin K.; Poté, John

doi:10.1016/j.ecoenv.2020.110767

Cited by 39 publications

(27 citation statements)

References 39 publications

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“…Total nitrogen (TN), pH, dissolved oxygen (DO), and heavy metals were the main drivers that affected the diversity of the bacterial community in Maozhou River under anthropogenic disturbances (Ouyang et al 2020). On the other hand, principal health risks are associated with waterborne pathogenic microorganisms from anthropogenic discharges, including domestic sewage, industrial wastes, hospital effluents, and urban/agricultural runoffs (Cui et al 2019;Wu et al 2019;Al Salah et al 2020;Zhang et al 2021). For instance, the bacteria Vibrio cholerae found in domestic sewage can result in severe gastroenteritis, which causes dehydration and death (Moehling et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Pollution profile of waterborne bacterial and fungal community in urban Rivers of Pearl River estuary: Microbial safety assessment

Wang

et al. 2021

Journal of Freshwater Ecology

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Waterborne pathogens in urban rivers of estuarine areas pose a great threat to human health. In this study, both bacterial and fungal community structures of four urban rivers in the Pearl River estuarine area were investigated using high-throughput sequencing. Results showed that the diversity and richness indices of the bacterial community were higher than that of fungi. Taxonomic analysis indicated that the most abundant bacterial phylum was Actinobacteria, while the most abundant fungal phylum was Ascomycota. In addition, 35 major pathogens were found at the level of genus with Mycobacterium being the most abundant. Specifically, pathogens of Burkholderiales, Bartonella, Rhizobiales, Bordetella and Brucella were first detected in this area, although with relative low abundances. Spearman correlation analysis revealed that temperature, TOC and TDP were significant factors shaping both total microbial community and pathogenic microbial community structure. TDP was positively correlated with almost all the potential pathogenic genera. PICRUSt analysis further predicted that bacterial infectious disease was the most abundant pathway associated with microbial functions of human disease in all the studied rivers. This work provides useful information not only for in-depth understanding of bacterial and fungal communities in urban rivers of estuarine areas under anthropogenic disturbances but also for environmental risk management of potential waterborne pathogens.

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Section: Introductionmentioning

confidence: 99%

Pollution profile of waterborne bacterial and fungal community in urban Rivers of Pearl River estuary: Microbial safety assessment

Wang

et al. 2021

Journal of Freshwater Ecology

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“…Microbial pollutants can also serve as indicators of water quality. Untreated effluents generated by hospital activities can contribute significantly to the spread of microbial pollutants mainly as multi-resistant bacteria (MRB) from patient's pathological products in the environment [2,[61][62]. Indeed, the diversity and huge consumption of antibiotics used in humans' therapies eventually of bacterial infection end up in the wastewaters [63][64][65].…”

Section: Bacterial Resistance To Antibiotics In Hospital Wastewatersmentioning

confidence: 99%

“…The large quantity of liquid effluents generated by hospital activities can contain many important micropollutants with various substances (drug residues, chemical reagents, antiseptics, detergents, etc.) and pathogenic agents [1][2][3]. These effluents, as well as conventional domestic wastewater, are usually discharged into urban networks without prior treatment [4,5].…”

Section: Introductionmentioning

confidence: 99%

Ecotoxicity of hospital wastewaters and their impact on bacterial multi-drug resistance: a review

Ouedraogo¹,

Souleymane²,

Ouedraogo³

et al. 2021

jlsb

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“…Although there are studies on ARB and ARGs in the urban river environment of DRC, most are restricted to hospital discharging points and no studies have yet been conducted to investigate the presence of heavy metals and correlating the presence of ARB and ARGs in this ecosystem (Al Salah et al 2020). Therefore, the present study aims to determine heavy metals in the water and sediment of two river systems receiving urban and hospital effluent waters and the correlation with ARB and ARGs.…”

Section: Introductionmentioning

confidence: 99%

“…Several factors other than antibiotics influence the spread and dissemination of ARGs in the environment (Devarajan et al 2015). More worryingly, in developing countries, such as Sub-Saharan African Responsible Editor: Robert Duran countries, the discharge of raw sewage into rivers is common (Al Salah et al 2020;Laffite et al 2020Laffite et al , 2016. This practice deteriorates the quality of freshwater resources by contaminants of ARGs, heavy metals, antibiotics and ARB Tripathi 2017, Ngweme et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Occurrence of toxic metals and their selective pressure for antibiotic-resistant clinically relevant bacteria and antibiotic-resistant genes in river receiving systems under tropical conditions

Salah

Laffite

Sivalingam³

et al. 2021

Environ Sci Pollut Res

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The co-occurrence of heavy metals, antibiotic-resistant bacteria (ARB) and antibiotic-resistance genes (ARGs) from hospital effluents spreading into the river receiving systems and evaluating associated risks are topics of scientific interest and still under-studied in developing countries under tropical conditions. To understand the selectors of the ARGs, we examined the occurrence of heavy metals (Cr, Co, Ni, Cu, Cd, Pb and Zn), associated ARB (β-lactam-resistant Escherichia coli, β-lactam-resistant Enterobacteriaceae, and carbapenem-resistant Enterobacteriaceae) and ARGs (blaOXA, blaCTX-M, blaIMP, blaTEM) in water and sediments from two sub-urban rivers receiving urban and hospital effluent waters in the Democratic Republic of the Congo (DRC). High abundances of ARB and ARGs were observed in all sediment samples. All the metal contents correlated negatively with grain size (− 0.94 ≤ r ≤ − 0.54, p < 0.05) except for Ni and positively with organic matter content and total copies of 16 s rRNA (0.42 ≤ r ≤ 0.79, p < 0.05), except for Ni and Zn. The metals had a significant positive correlation with the faecal indicator Enterococcus except for Ni and Cd (0.43 ≤ r ≤ 0.67, p < 0.05). Carbapenem-resistant Enterobacteriaceae correlated negatively with Zn (r = − 0.44, p < 0.05) and positively with all the rest of toxic metals (0.58 ≤ r ≤ 1.0, p < 0.05). These results suggested that some metals had a great influence on the persistence of ARB and ARGs in sediments. Overall, this study strongly recommends the managing urban wastewater to preserve water resources used for human and agricultural purposes. Additionally, we recommend the utilizing biological indicators (faecal indicator bacteria, ARB, ARGs) when investigating urban wastewater pollutions.

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Hospital wastewaters: A reservoir and source of clinically relevant bacteria and antibiotic resistant genes dissemination in urban river under tropical conditions

Cited by 39 publications

References 39 publications

Pollution profile of waterborne bacterial and fungal community in urban Rivers of Pearl River estuary: Microbial safety assessment

Pollution profile of waterborne bacterial and fungal community in urban Rivers of Pearl River estuary: Microbial safety assessment

Ecotoxicity of hospital wastewaters and their impact on bacterial multi-drug resistance: a review

Occurrence of toxic metals and their selective pressure for antibiotic-resistant clinically relevant bacteria and antibiotic-resistant genes in river receiving systems under tropical conditions

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