Host-tumor interaction and nutrient supply

Buzby, Gordon P.; Mullen, James L.; Stein, T. P.; Miller, Elizabeth E.; Hobbs, Charles L.; Rosato, Ernest F.

doi:10.1002/1097-0142(19800615)45:12<2940::aid-cncr2820451208>3.0.co;2-p

Cited by 137 publications

(33 citation statements)

References 33 publications

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“…These findings give support for parenteral nutrition studies in the wasted cancer patient where some consideration is now being given to the parenteral infusion of lipid, rather than glucose, with potential benefits in the maintenance of body weight and lack of tumour progression (Magee et al, 1979;Conyers et al, 1979b;Buzby et al, 1980;Brennan, 1981).…”

Section: Blood and Liver Metabolitesmentioning

confidence: 70%

“…While the effect of starvation on tumour growth in experimental animals has been considered (Goodgame et al, 1979;Buzby et al, 1980), little information is available on the extent to which tumour-bearing modifies the normal ketonaemic response to starvation. In the study reported here, we describe the metabolic adaptation to starvation in tumour-bearing and control mice after periods of identical dietary intake.…”

mentioning

confidence: 99%

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The metabolic response of tumour-bearing mice to fasting

Rofe¹,

Porter²,

Bais³

et al. 1985

Br J Cancer

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Summary The suggestion that the ketonaemic response to fasting may be altered in the tumour-bearing state was investigated by studying the metabolism of fasted C57/BL6j mice bearing transplanted B16 melanomas. Ketone body (D-3-hydroxybutyrate and acetoacetate) concentrations in the blood of the tumour-bearing mice were significantly increased after a 24h fast compared to control mice with identical dietary histories. Hepatic glycogen levels were lower at the start of the fasting period in the tumour-bearing mice as were the fat stores. The loss of adipose tissue during the fasting period was greater in the tumour-bearing mice. After 48 h of fasting, the ketonaemia was significantly lower in the tumour-bearing mice compared to the appropriate controls. Two distinct metabolic states are indicated in these fasted tumour-bearing mice, one characterised by accelerated ketonaemia, and a later, near terminal stage, where fat deposits are markedly depleted and ketonaemia is decreased.

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Section: Blood and Liver Metabolitesmentioning

confidence: 70%

mentioning

confidence: 99%

The metabolic response of tumour-bearing mice to fasting

Rofe¹,

Porter²,

Bais³

et al. 1985

Br J Cancer

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“…We hypothesized that reduction of protein thiol values in serum of females with MGT in the second group in our study might have been due to the higher rate of protein oxidation or increased uptake of antioxidants by tumourous tissues. Buzby et al (1980) described that malignant cells could scavenge antioxidants from circulation for their supplement. The value of non-protein thiols in serum was higher in females of group 2 under anaesthesia 10 min after surgery than in healthy anaesthetized females of (control) group 3.…”

Section: Discussionmentioning

confidence: 99%

Markers of oxidative and antioxidative activity in female dogs with mammary gland tumour with and without additional vitamin E supplementation

et al. 2012

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The present study determined markers of oxidative and antioxidative activity in dog females affected with mammary gland tumour compared to healthy ones. The effect of additional vitamin E supplementation on oxidative and antioxidative status was evaluated as well. The study included 29 female dogs divided into 4 groups (groups 1 and 2 included females with a mammary gland tumour; groups 3 and 4 included healthy female dogs). Additional vitamin supplement containing α-tocopherol was given to the females of groups 1 and 4. Dogs from groups 1 and 2 were anaesthetized before surgery (ovariohysterectomy and mastectomy); anaesthesia was used also in group 3, but without performeing surgery. The content of vitamin E (free α-tocopherol), marker of antioxidative status, was measured in blood serum by liquid chromatography. The concentration of thiobarbituric acid reactive substances, marker of oxidative status, in serum and concentrations of protein and non-protein thiol groups, markers of oxidative and antioxidative status, in blood serum and in red blood cells were measured colorimetrically. In females with a mammary gland tumour from group 2, concentration of thiobarbituric acid reactive substances was significantly higher than 14 days after surgery and compared to healthy ones as well. In females with a mammary gland tumour from group 2, concentration of protein thiol groups in serum was significantly lower and concentration of non-protein thiol groups in serum was significantly higher than in healthy controls. The values of protein thiols in erythrocytes in females with mammary gland tumour from group 1 were significantly higher before supplementation with vitamin E. The present study revealed that females with a mammary gland tumour were more burdened with oxidative stress compared to healthy dogs. The removal of the mammary gland tumour led to improvement of oxidative and antioxidative status. This is the first report focusing on the effect of additional α-tocopherol supplementation on reducing oxidative stress by increasing antioxidative activity in females affected with mammary gland tumour; however, we did not prove it. , ovariohysterectomy, α-tocopherol, thiobarbituric acid reactive substances, protein and non-protein thiol groups Mastectomy

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“…GST is vital antioxidant present in cells. Rapid GST synthesis in tumour cells is associated with high rates of cell proliferation, while GSH depletion is sufficient to sensitize cancer cells to the cytotoxic effects of oxidative and nitrative stress and make them more defenseless to the effects of anticancer drugs or the genes that promote apoptosis [22].…”

Section: Resultsmentioning

confidence: 99%