Hot infusions and risk of colorectal cancer in Uruguay: a case–control study

Ronco, Álvaro L.; Stéfani, Eduardo De; Lasalvia-Galante, Eduardo; Mendoza, Beatriz; Vázquez, Alvaro J.; Sanchez, Gustavo Tadeu

doi:10.1038/ejcn.2017.130

Cited by 10 publications

(8 citation statements)

References 48 publications

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“…Results show a negative correlation between daily yerba mate intake and breast cancer [12][13]. In another study, high yerba mate intake had a significant inverse correlation with colorectal cancer onset [14].…”

Section: Introductionmentioning

confidence: 87%

Anti-proliferative activity of yerba mate (Ilex paraguariensis) aqueous extracts on human colorectal cancer cell lines

Saleh

Othman

Elchoueiry

et al. 2021

FFHD

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Background: Yerba mate, a popular, tea-like beverage prepared from the dried leaves of Ilex paraguariensis, is widely consumed, and has several reported health benefits. Compared with other herbal teas, the effect of yerba mate on human cells in the context of cancer has not been extensively studied. The method of extraction of bioactive compounds from the yerba mate leaves plays an important role in its effect on cancer cells. Methods: In this study we assessed the viability, anti-proliferative, and apoptotic effect of the aqueous yerba mate extract, prepared using the same conditions employed for consumption, on different human colorectal cancer cell lines (Caco-2, HT-29, and HCT116) and on the non-tumorigenic human colon epithelial cell line (NCM460).Results: Cytotoxicity of aqueous yerba mate extract was studied and a dose-dependent decrease in viability was observed in all the tested cell lines. At 24 hrs., viability decreased to 19.7% with Caco-2 cells, 2.7% with HCT116, and 8.4% with HT-29 cells at a concentration of 4.8 mg/mL of yerba mate extract. The effect was less prominent on the NCM460 cell line where the viability of cells at the same concentration was 65.2%. Yerba mate extract also showed concentration-dependent anti-proliferative effects as determined by the WST-1 proliferation kit. IC50 values ranged between 0.22-0.69 mg/mL at 24 hr for cell lines tested. To study whether cell death was due to apoptosis, Caco-2 cells were stained with Annexin V-FITC assay and an increase in the percentage of late apoptotic Caco-2 cells was observed with yerba mate extract at 0.6-4.8 mg/mL. Cell cycle analysis using DNA content by flow cytometry showed an increase in the percentage of Caco-2 cells in the subG0/G1 phase and the G0/G1 phase after treatment with 2.4 mg/mL extract. Collectively, our data suggest that yerba mate aqueous extract exhibits an anti-proliferative effect on tested cell lines by inducing apoptosis. Conclusions: Yerba mate aqueous extract exhibits a strong anti-proliferative activity against adenocarcinoma cell lines studied and constitutes a promising functional food adjuvant to anti-cancer therapy. Further work is needed to identify active components and mechanisms of action. Keywords: Aqueous extract, yerba mate, anti-proliferative activity, adenocarcinoma cell lines

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Section: Introductionmentioning

confidence: 87%

Anti-proliferative activity of yerba mate (Ilex paraguariensis) aqueous extracts on human colorectal cancer cell lines

Saleh

Othman

Elchoueiry

et al. 2021

FFHD

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“…In previous studies, this infusion was identified as a risk factor for oral, esophageal, and laryngeal cancer (Loria, Barrios, & Zanetti, 2009;Ronco et al, 2004;Sewram, De Stéfani, Brennan, & Boffetta, 2003). In the first epidemiological study of its kind, Ronco et al (2017) found an inverse relation between mate consumption and CRC incidence rates, suggesting that mate is a protective factor for this cancer type. The aforementioned carcinogenicity found for other cancer types has been linked to the hot temperature at which mate is traditionally consumed rather than to chemical compounds inherent within mate (Ghassan Riachi & Bastos De Maria, 2017).…”

Section: Risk Factors For Crcmentioning

confidence: 99%

Colorectal cancer screening in Uruguay: current assessment and roadmap for the future

Reich

Buki

2021

Psicol. Refl. Crít.

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Cancer is a leading cause of death worldwide and is expected to remain a public health concern for years to come. Within Latin America, Uruguay has the highest colorectal cancer rates. Heeding past calls to action, in this article we provide a critical assessment of colorectal cancer needs and opportunities in Uruguay with a focus on developing a roadmap for future action. First, we provide an overview of risk factors, screening procedures and guidelines, and screening rates. Next, we provide an overview of psychosocial factors that influence colorectal cancer screening, with the goal of providing guidance for future behavioral health promotion initiatives in Uruguay. In this effort, we present four conceptual models that may be used for interventions: the ecological systems theory, informed decision-making, the health beliefs model, and the health literacy model. Subsequently, we propose using an integrated model based on the ecological systems theory and health literacy model to develop national, local, and community-based interventions to increase screening rates and lower the colorectal cancer burden in Uruguay. We close the paper with a summary and implications section, including recommendations for future research programs focused on the assessment of factors that influence screening.

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“…In 1990, the International Agency for Research on Cancer office of the WHO (IARC) classified series of publications that linked consumption with different types of cancer, mainly the oropharynx [17,18]. Since then, research has been carried out to demonstrated a link between the consumption of hot beverages and cancer, as well as an antimutagenic and protective effect of the yerba mate infusion [19][20][21]. On the other hand, there are some authors who claimed that polycyclic aromatic hydrocarbons (PAH) derived from the incomplete combustion of wood as contaminants present in the yerba mate leaf, are responsible for the association between the infusion and cancer, because of the presence of PAH as they are recognized carcinogenic agents [22].…”

Section: Mini Reviewmentioning

confidence: 99%

Ilex Paraguariensis as a Healthy Food Supplement for the Future World

Bracesco

2019

BJSTR

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Hot infusions and risk of colorectal cancer in Uruguay: a case–control study

Cited by 10 publications

References 48 publications

Anti-proliferative activity of yerba mate (Ilex paraguariensis) aqueous extracts on human colorectal cancer cell lines

Anti-proliferative activity of yerba mate (Ilex paraguariensis) aqueous extracts on human colorectal cancer cell lines

Colorectal cancer screening in Uruguay: current assessment and roadmap for the future

Ilex Paraguariensis as a Healthy Food Supplement for the Future World

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