How body position changes visual vertical perception after unilateral vestibular loss

Lopez, Christophe; Lacour, Michel; Léonard, Jacques; Magnan, Jacques; Borel, Liliane

doi:10.1016/j.neuropsychologia.2008.03.017

Cited by 37 publications

(35 citation statements)

References 36 publications

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“…In the literature, acutely after UVH a strong bias of the SVV and the subjective visual horizontal (SVH) towards the lesioned side (up to 25° (Friedmann, 1971, Curthoys et al , 1991, Bergenius et al , 1996, Anastasopoulos et al , 1997, Lopez et al , 2008) has been described consistently. While this bias slowly decreases, not all patients reach normal values after months to years (Friedmann, 1970, Curthoys et al , 1991, Böhmer et al , 1995, Tribukait et al , 1998, Hafström et al , 2004, Hafstrom et al , 2006, Lopez et al , 2008, Toupet et al , 2014, with adjustment errors between -2.0° and 11.7°.…”

Section: Discussionmentioning

confidence: 97%

“…While this bias slowly decreases, not all patients reach normal values after months to years (Friedmann, 1970, Curthoys et al , 1991, Böhmer et al , 1995, Tribukait et al , 1998, Hafström et al , 2004, Hafstrom et al , 2006, Lopez et al , 2008, Toupet et al , 2014, with adjustment errors between -2.0° and 11.7°. These results are consistent with our observation of a trend (3.7±2.0°, p=0.100) towards an ipsilesional SVV bias when upright.…”

Section: Discussionmentioning

confidence: 99%

“…The SVV thereby shifts towards the lesioned side when upright (Friedmann, 1971, Curthoys et al , 1991, Bergenius et al , 1996, Anastasopoulos et al , 1997, Lopez et al , 2008. Healthy humans show a distinct pattern of roll-angle dependent SVV errors: while roll over-compensation occurs at small (<60°) and very large (>120-135°) (Tarnutzer et al , 2009a) angles (E-effect) (Mueller, 1916), roll undercompensation is found for medium-sized (60-135°) angles (A-effect) (Aubert, 1861).…”

Section: Introductionmentioning

confidence: 99%

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Spatial orientation in patients with chronic unilateral vestibular hypofunction is ipsilesionally distorted

Müller

Bockisch

Tarnutzer

2016

Clinical Neurophysiology

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OBJECTIVE Acute unilateral peripheral-vestibular hypofunction (UVH) shifts the subjective visual vertical (SVV) ipsilesionally, triggering central compensation that usually eliminates shifts when upright. We hypothesized that compensation is worse when roll-tilted. METHODS We quantified SVV errors and variability in different roll-tilted positions (0°, ±45°, ±90°) in patients with chronic UVH affecting the superior branch (SVN; n=4) or the entire (CVN; n=9) vestibular nerve. RESULTS Errors in SVN and CVN were not different. When roll-tilted ipsilesionally 45°(9.6±5.4°vs. -0.2±6.4°, patients vs. controls, p<0.001) and 90°(23.5±5.7°vs. 16.8±8.8°, p=0.003), the patient's SVV was shifted significantly towards the lesioned ear. When upright, only a trend was noted (3.6±2.2°vs. 0.0±1.2°, p=0.099); for contralesional roll-tilts shifts were not different from controls. Variability was larger for CVN than SVN (p=0.046). With increasing disease-duration, adjustment errors decayed for ipsilesional roll-tilt and upright (p0.025). CONCLUSIONS The reason verticality perception was distorted for ipsilesional roll-tilts, may be the insufficient integration of contralesional otolith-input. Similar errors in SVN and CVN suggest a dominant utricular role in verticality perception, albeit the sacculus may improve precision of SVV estimates. SIGNIFICANCE With deficiencies in central compensation being roll-angle dependent, extending SVV-testing to roll-tilted positions may improve identifying patients with chronic UVH. Highlights:• Visual vertical (VV) was measured in 13 patients with chronic unilateral vestibular hypofunction.• VV shifts in the patients were significant only when rolled ipsilesionally.• Thus VV testing in roll-tilted positions is recommended to identify more subtle vestibular deficits. 3 AbstractObjective: Acute unilateral peripheral-vestibular hypofunction (UVH) shifts the subjective visual vertical (SVV) ipsilesionally, triggering central compensation that usually eliminates shifts when upright. We hypothesized that compensation is worse when roll-tilted. Methods

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spatial orientation in patients with chronic unilateral vestibular hypofunction is ipsilesionally distorted

Müller

Bockisch

Tarnutzer

2016

Clinical Neurophysiology

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“…The vestibular system is primarily involved in gaze stabilization and postural control (23), but its influence has been expanded to autonomic and bone regulation (11,61,63), spatial learning and memory (5,6,56), and spatial orientation and perception of gravitational verticality (37). Studies carried out in environments in which gravity is altered have shown evidence of a possible influence of the vestibular system on hypothalamic circadian function in rats (27) and mice (18,46); disruption of circadian rhythms of temperature (Temp) and locomotor activity (Act) have been similarly observed in both species for about 7 days in a 2 G environment generated by a centrifuge.…”

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confidence: 99%

Vestibular loss disrupts daily rhythm in rats

Martin

Mauvieux

Bulla

et al. 2015

Journal of Applied Physiology

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Hypergravity disrupts the circadian regulation of temperature (Temp) and locomotor activity (Act) mediated through the vestibular otolithic system in mice. In contrast, we do not know whether the anatomical structures associated with vestibular input are crucial for circadian rhythm regulation at 1 G on Earth. In the present study we observed the effects of bilateral vestibular loss (BVL) on the daily rhythms of Temp and Act in semipigmented rats. Our model of vestibular lesion allowed for selective peripheral hair cell degeneration without any other damage. Rats with BVL exhibited a disruption in their daily rhythms (Temp and Act), which were replaced by a main ultradian period ( Ͻ20 h) for 115.8 Ϯ 68.6 h after vestibular lesion compared with rats in the control group. Daily rhythms of Temp and Act in rats with BVL recovered within 1 wk, probably counterbalanced by photic and other nonphotic time cues. No correlation was found between Temp and Act daily rhythms after vestibular lesion in rats with BVL, suggesting a direct influence of vestibular input on the suprachiasmatic nucleus. Our findings support the hypothesis that the vestibular system has an influence on daily rhythm homeostasis in semipigmented rats on Earth, and raise the question of whether daily rhythms might be altered due to vestibular pathology in humans. vestibular system; biological rhythms; temperature; locomotor activity; rats LOCATED IN THE TEMPORAL BONES, the vestibular system is composed of three semicircular canals that encode head rotation velocity and two otolithic macula that encode linear acceleration and gravity force. The vestibular system is primarily involved in gaze stabilization and postural control (23), but its influence has been expanded to autonomic and bone regulation (11,61,63), spatial learning and memory (5, 6, 56), and spatial orientation and perception of gravitational verticality (37). Studies carried out in environments in which gravity is altered have shown evidence of a possible influence of the vestibular system on hypothalamic circadian function in rats (27) and mice (18,46

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“…In most of these studies (1-8,10-12) subjects were required to manually align the rod with respect to their subjective vertical, eventually leading to confounds between visual and proprioceptive (haptic) inputs. To prevent proprioceptive cues from contaminating visually based verticality judgments, we chose a verbal forcedchoice paradigm in which the stimuli were presented in a semi-automatic manner thus allowing precise angulations of the rod tilt without any manual intervention (although other potential sources of proprioceptive cues stemming from subject's body posture are known to modulate visual dependency) (22)(23)(24). Furthermore, we took advantage of the fact that increment thresholds obtained by forced choice can be significantly smaller than those obtained with a yes-no procedure (16).…”

Section: Discussionmentioning

confidence: 99%

Semi-automatic measurement of visual verticality perception in humans reveals a new category of visual field dependency

Kaleff

Aschidamini

Baron

et al. 2011

Braz J Med Biol Res

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How body position changes visual vertical perception after unilateral vestibular loss

Cited by 37 publications

References 36 publications

Spatial orientation in patients with chronic unilateral vestibular hypofunction is ipsilesionally distorted

Spatial orientation in patients with chronic unilateral vestibular hypofunction is ipsilesionally distorted

Vestibular loss disrupts daily rhythm in rats

Semi-automatic measurement of visual verticality perception in humans reveals a new category of visual field dependency

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