How does Eucommia leaf extract prevent smooth muscle cell proliferation induced by high-fat diets at the aortic tunica media?

Takayama, Fusako; Fujihara, Yuri

doi:10.1038/hr.2017.22

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…According to recent reports, Eucommia ulmoides bark and Eucommia ulmoides leaf have shown the following various effects on health: hepatoprotective [15,16], neuroprotective and hypnotic [17][18][19][20][21][22], anti-obesity and anti-metabolic syndrome [10,[23][24][25][26], antibacterial [27], antiviral [28], anti-inflammatory [29,30], inhibitory action against diabetic complications [31][32][33], antioxidative [8,[34][35][36][37], antihypertensive [38][39][40][41], anticancer [42,43] and bone metabolism effects [2,3,[7][8][9]13,14,[44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Promotion of osteoblastic Ca2+ accumulation by Eucommia leaf extract

Oikawa¹,

Miyazaki²,

Nishida³

et al. 2017

Glob Drugs Therap

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Section: Discussionmentioning

confidence: 99%

Promotion of osteoblastic Ca2+ accumulation by Eucommia leaf extract

Oikawa¹,

Miyazaki²,

Nishida³

et al. 2017

Glob Drugs Therap

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“…Stigmasterol 7 was also reported to possess neuroprotective effects by modulating GABA receptors and suppressing the progression of cell apoptosis via mitogen-activated protein kinase (MAPK) proteins cyclin D1, p53, and p38 reduction [62]. On the other hand, Takayama and Fujihara in 2017 investigated whether asperuloside 11 isolated from Eucommia ulmoides could alleviate ROS production in choline-deficient, high fat and fructose-enriched (CDHFF)-diet rats [63]. Thereby, these provide evidence that stigmasterol 7 and asperuloside 11 possess promising constituents for the management of diabetic neuropathy associated with neurological damage due to oxidative stress.…”

Section: Paederia Foetidamentioning

confidence: 99%

Indonesian Vegetables: Searching for Antioxidant and Antidiabetic Therapeutic Agents

Rani

Hanafi

Sudarko

et al. 2023

DDC

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Diabetes mellitus prevalence in Indonesia reached 19.5 million cases, which has affected the productive age population. The indigenous people of Indonesia are blessed with the second largest biodiversity in the world, including vegetables, which are also prepared as medicaments. Vegetables are well-known as natural antioxidants which evolved in metabolic disease prevention, including diabetes mellitus. One of the Government of Indonesia’s strategic plans in health is to develop new antidiabetic from nature. In this study, nineteen vegetable species were collected and evaluated for their antioxidant activity followed by computational-based bioprospecting. The study indicated Ipomoea aquatica, Paederia foetida, Plumbago zeylanica, Nauclea pallida, Sauropus androgynus, Wrightia pubescens, and Psophocarpus tetragonolobus to contain high antioxidant components. Computational experiments on chemical constituents previously reported from the same species showed potent compounds with high affinity against α-glucosidase (3a4a). 7-O-β-D-glucopyranosyl-dihydroquercetin-3-O-α-D-glucopyranoside 1, stigmasterol 7, and chitanone 12 are the most potent compounds from Ipomoea aquatica, Paederia foetida, and Plumbago zeylanica, respectively, which are superior to a standard drug, acarbose. The four vegetable species are feasible for conventional drug sources or developed as botanical dosage according to the Indonesian government’s strategic plan. Further studies are necessary to ensure adequate preclinical and clinical data to meet the requirement of safe and potent medicine. Nevertheless, Nauclea pallida and Psophocarpus tetragonolobus are valuable species with potent yet understudied antioxidant sources.

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