How might we increase success in marine-based drug discovery?

Desbois, Andrew P.

doi:10.1517/17460441.2014.927863

Cited by 16 publications

(15 citation statements)

References 26 publications

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“…Whereas the natural environment is regarded as a rich source of unique chemical diversity, the reduced trend in the discovery of new bioactive compounds as well as the frequent rediscovery of previously identified compounds have been an increasing challenge for the field of drug discovery from natural products (Lam, ; Li & Vederas, ). Despite that, many has turned their focus toward natural products derived from difficult‐to‐reach sources/habitats to increase the opportunities for finding novel chemical entities (Desbois, ; Xu, ).…”

Section: Introductionmentioning

confidence: 99%

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

et al. 2019

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Microbial natural products serve as a good source for antioxidants. The mangrove‐derived Streptomyces bacteria have been evidenced to produce antioxidative compounds. This study reports the isolation of Streptomyces sp. MUM273b from mangrove soil that may serve as a promising source of antioxidants and UV‐protective agents. Identification and characterization methods determine that strain MUM273b belongs to the genus Streptomyces. The MUM273b extract exhibits antioxidant activities, including DPPH, ABTS, and superoxide radical scavenging activities and also metal‐chelating activity. The MUM273b extract was also shown to inhibit the production of malondialdehyde in metal‐induced lipid peroxidation. Strong correlation between the antioxidant activities and the total phenolic content of MUM273b extract was shown. In addition, MUM273b extract exhibited cytoprotective effect on the UVB‐induced cell death in HaCaT keratinocytes. Gas chromatography–mass spectrometry analysis detected phenolics, pyrrole, pyrazine, ester, and cyclic dipeptides in MUM273b extract. In summary, Streptomyces MUM273b extract portrays an exciting avenue for future antioxidative drugs and cosmeceuticals development.

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Section: Introductionmentioning

confidence: 99%

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

et al. 2019

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“…Furthermore, these organisms suffer fierce survival competition, and the chemicals, or secondary metabolites, help marine organisms to survive, reproduce, and resist predators [ 7 , 10 ]. The therapeutic agents derived from these chemicals can be unaltered natural products, chemically altered derivatives, or their structure might have been inspired by natural marine products [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

et al. 2018

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The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification.

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“…The recent findings indicating that marine invertebrate-associated microbes may be the true producers of secondary metabolites with potential clinical applications, namely in oncology, can provide viable approaches for the sustainable supply of intermediate or even lead structures. This hypothesis has attracted considerable interest and represents an exciting alternative since, unlike marine animal resources, the supply issue is less problematic for marine microorganisms through animal-independent or even culture-independent production methods [ 58 ].…”

Section: Solutions To the “Supply Problem”mentioning

confidence: 99%

“…Notably, in addition to serving as an alternative supply tool for unculturable marine microbes, metagenomics uncovers also the existence of silent gene clusters, constituting a relevant proportion of the microbial genome usually inactive through culture-dependent methods. Allowing their expression may give access to the full metabolic potential of unculturable bacteria making it possible to discover, isolate, and produce new secondary metabolites, potentially with relevant anticancer properties [ 58 , 100 , 164 , 165 ]. Still, despite the exciting results obtained through metagenomics, the scale up production of a compound through the heterologous expression methods remains a challenge and their definitive affirmation as feasible and efficient solutions to deliver sufficient quantities for clinical development and subsequent commercialization is still lacking.…”

Section: Solutions To the “Supply Problem”mentioning

confidence: 99%

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the “Supply Problem”

et al. 2016

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Marine invertebrates provide a rich source of metabolites with anticancer activities and several marine-derived agents have been approved for the treatment of cancer. However, the limited supply of promising anticancer metabolites from their natural sources is a major hurdle to their preclinical and clinical development. Thus, the lack of a sustainable large-scale supply has been an important challenge facing chemists and biologists involved in marine-based drug discovery. In the current review we describe the main strategies aimed to overcome the supply problem. These include: marine invertebrate aquaculture, invertebrate and symbiont cell culture, culture-independent strategies, total chemical synthesis, semi-synthesis, and a number of hybrid strategies. We provide examples illustrating the application of these strategies for the supply of marine invertebrate-derived anticancer agents. Finally, we encourage the scientific community to develop scalable methods to obtain selected metabolites, which in the authors’ opinion should be pursued due to their most promising anticancer activities.

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How might we increase success in marine-based drug discovery?

Cited by 16 publications

References 26 publications

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

Streptomyces sp. MUM273b: A mangrove‐derived potential source for antioxidant and UVB radiation protectants

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the “Supply Problem”

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