How much separation sciences fit in the green chemistry canoe?

Sagandykova, Gulyaim; Szumski, Michał; Buszewski, Bogusław

doi:10.1016/j.cogsc.2021.100495

Cited by 11 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, good sensitivity and precision along with the high accuracy of the assay of target compounds might make the CE‐ESI‐MS/MS method a useful tool in clinical laboratories for the therapeutic drug monitoring of antibiotics and in forensic laboratories owing to their determination and higher levels in human fluids. Among methods available in the literature [12–20], the proposed method provided better accuracy and precision. Additionally, it is suitable to determine analytes in complex matrices, and it requires only small sample volumes.…”

Section: Resultsmentioning

confidence: 99%

CE‐DAD‐MS/MS in the simultaneous determination and identification of selected antibiotic drugs and their metabolites in human urine samples

et al. 2021

Self Cite

View full text Add to dashboard Cite

In this study, a new analytical method was developed and validated for the simultaneous analysis of antibiotic drugs (amoxicillin, cefotaxime, ciprofloxacin, clindamycin, linezolid, metronidazole) and their metabolites (amoxycilloic acid, amoxicillin diketopiperazine, 3-desacetyl cefotaxime lactone, clindamycin sulfoxide, ciprofloxacin piperazinyl-N4sulfate, linezolid N-oxide, metronidazole-OH) in human urine. Capillary electrophoresis (CE) along with the tandem mass spectrometry (MS/MS) was used to determine and identify all analytes. Appropriate conditions for MS/MS measurements along with the use of the central composite design were optimized. The effects of different analytical conditions (the composition, the concentration, and the pH value of the background electrolyte, the time and pressure of the injection, the capillary temperature and influence of the organic modifier) on the migration and separation of antibiotic drugs and metabolites were examined using the CE-DAD. The analytical procedure was linear for concentrations ranging from 20 to 1000 ng/mL, with determination coefficients higher than 0.99 for all the analytes. The validated analytical procedure was then applied to the measurement of antibiotic drugs and their metabolites in human urine samples.

show abstract

Section: Resultsmentioning

confidence: 99%

CE‐DAD‐MS/MS in the simultaneous determination and identification of selected antibiotic drugs and their metabolites in human urine samples

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Three independent variables of extraction on three levels were optimized using the response surface methodology (RSM). The optimized parameters were the desorption time (5-15 min), the pH of the desorption solvent (3)(4)(5)(6)(7)(8)(9)(10), and the volume of the desorption solvent (30-100 µL). An optimization study for the three parameters was performed with the use of Statistica 12.0 (StatSoft, Tulsa, OK, USA).…”

Section: Spme-optimization Of Extraction Parametersmentioning

confidence: 99%

“…The methodology with the desorption time (5-15 min), the pH of the desorption solvent (3)(4)(5)(6)(7)(8)(9)(10) and the volume of the desorption solvent (30-100 μL) as the three variables requires a significantly smaller number of experiments than the traditional "one variable at a time" methodology. The CCD was executed requiring 15 experiments.…”

Section: Optimization Of Mip-spme Extraction Through Experimental Design (Doe)mentioning

confidence: 99%

“…The huge diversity of samples due to the composition and aggregate state of the matrix requires the use of many techniques of the sample preparation to extract the tested compounds and to purify them prior to the determination and identification step. An important stage in the preparation of the sample for the final analysis is its isolation and/or enrichment, which consists in transferring the analytes from the primary matrix to the secondary matrix with the simultaneous removal of interfering substances (isolation) and increasing the concentration of the analytes to a level above the quantification limit of the analytical methodology (enrichment) [1,4,5]. The application of extraction techniques such as the liquid-liquid extraction (LLE), the solid-phase extraction (SPE), and the super fluid extraction (SFE) allows us to separate the analyte from the matrix, to eliminate or reduce interferences from other components, Materials 2021, 14, 4886 2 of 22 and to enrich the analyte to a level that allows for the appropriate determination.…”

Section: Introductionmentioning

confidence: 99%

“…In the era of "green chemistry", it is more and more difficult to justify the use of analytical methods with the use of large amounts of toxic solvents at any stage of the sample preparation. Hence, solvent-free methods are preferred [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecularly Imprinted Polymers as Solid-Phase Microextraction Fibers for the Isolation of Selected Antibiotics from Human Plasma

2021

Self Cite

View full text Add to dashboard Cite

The aim of this study was to examine the synthesis of novel molecularly imprinted polymer (MIP)-coated polythiophene and poly(3-methylthiophene) solid-phase microextraction fibers using the direct electropolymerization method. Synthesized SPME fibers were characterized with the use of various physicochemical instrumental techniques. MIP-SPME coatings were successfully applied to carry out the selective extraction of selected antibiotic drugs (amoxicillin, cefotaxime, metronidazole) and their metabolites (amoxycilloic acid, amoxicillin diketopiperazine, desacetyl cefotaxime, 3-desacetyl cefotaxime lactone, hydroxymetronidazole). Solid-phase microextraction parameters for the simultaneous determination and identification of target compounds were optimized using the central composite design (CCD), and they accounted for 5–15 min for desorption time, 3–10 for the pH of the desorption solvent, and 30–100 μL for the volume of the desorption solvent. High-performance liquid chromatography and mass spectrometry (MS) detectors such as quadrupole time-of-flight (Q-TOF MS) and triple quadrupole (QqQ MS) were applied to determine and to identify selected antibiotic drugs and their metabolites. The MIP-coated SPME are suitable for the selective extraction of target compounds in biological samples from patients in intensive care units.

show abstract