How predictors and patterns of stroke recurrence after a TIA differ during the first year of follow-up

Purroy, Francisco; Caballero, Pedro Enrique Jiménez; Gorospe, A A; Torres, María José; Álvarez-Sabín, José; Martínez-Sánchez, Patricia; Cánovas, David; Freijo, Mar; Egido, J.; Ramírez-Moreno, J.M.; A, Alonso-Arias; Rodríguez-Campello, Ana; Casado-Naranjo, Ignacio; Martí‐Fàbregas, Joan; Silva, Y.; Cardona, Pere; Morales, A.; García-Pastor, Andrés; Arenillas, Juan F.; Segura, Tomás; Jiménez, Carmen; Masjuán, Jaime

doi:10.1007/s00415-014-7390-z

Cited by 10 publications

(21 citation statements)

References 31 publications

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“…Kernan et al reported that prior stroke was a predictor of recurrent stroke after a TIA or stroke ( 27 ). In the PROMAPA study-a multicenter prospective TIA registry operating from 30 Spanish centers-prior stroke and coronary heart disease were independent predictors of late (from 7 days to 1 year after the onset of a TIA) recurrent stroke after a TIA ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Predictors of Stroke Events in Patients with Transient Ischemic Attack Attributable to Intracranial Stenotic Lesions

et al. 2018

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Abstract:Objective The purpose of this study was to identify the predictors of subsequent ischemic stroke events in patients with transient ischemic attack (TIA) attributable to intracranial arterial occlusive lesions. Methods The study population included 82 patients (55 men; mean age, 69.3±12.1 years) with TIA caused by intracranial arterial occlusive lesions who were admitted to our stroke care unit within 48 h of the onset of a TIA between April 2008 and November 2015. TIA was diagnosed if focal neurological symptoms ascribable to a vascular etiology lasted less than 24 h, irrespective of the presence of ischemic insults on imaging. The primary endpoint was an ischemic stroke event within 90 days of the onset of a TIA. Results The 90-day risk of ischemic stroke after the onset of a TIA was 14.6% [95% confidence interval (CI): 8.6-23.9%]. Cox proportional hazards multivariate analyses revealed that diffusion-weighted imaging (DWI) positivity [hazard ratio (HR), 8.73; 95%CI, 2.20-41.59; p=0.002], prior ischemic stroke (HR, 4.03; 95%CI, 1.07-15.99; p=0.040), and a high serum level of alkaline phosphatase (ALP) on admission (HR, 1.15; 95%CI, 1.05-1.26; p=0.002, for every +10 U/L) were significant independent predictors of ischemic stroke within 90 days after the onset of a TIA. Conclusion Our results suggested that patients with a TIA attributable to intracranial artery disease who showed DWI lesions, prior ischemic stroke, or high serum levels of ALP on admission were at high risk of subsequent ischemic stroke events.

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Section: Discussionmentioning

confidence: 99%

Predictors of Stroke Events in Patients with Transient Ischemic Attack Attributable to Intracranial Stenotic Lesions

et al. 2018

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“…A total of 71 studies were included (A. Mowla, MD, unpublished data, 2020). 9 , 15 , 27 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 ...…”

Section: Resultsmentioning

confidence: 99%

“… 15 , 33 , 34 , 35 , 36 , 37 , 40 , 61 , 67 , 68 , 81 , 85 , 87 , 93 The setting of care was not fully described or the study included the patients who received treatment in various care settings and multiple centers in 37 cohorts (87 303 patients; mean [SD] age, 70.8 [3.8] years, 43 495 of 87 303 [49.8%] men). 27 , 42 , 43 , 44 , 45 , 46 , 47 , 50 , 51 , 53 , 59 , 60 , 62 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 81 , 86 , 88 , 89 , 90 , 92 , 94 Eight studies 9 , 32 , 51 , 52 , 53 , 58 , 59 (and A. Mowla, MD, unpublished data, 2020) provided the outcome of the patients in both inpatient and TIA clinic cohorts. The risk of subsequent stroke was reported for 35 356 patients within 2 days, 36 134 patients within 7 days, 142 185 patients within 30 days, and 94 731 patients within 90 days.…”

Section: Resultsmentioning

confidence: 99%

“…As presented in the eTable 4 in the Supplement , the difference among estimated risk of subsequent stroke measured by seven estimators (DL, HE, HS, ML, REML, SJ, and EB) was negligible. The forest plots based on the REML estimator 43 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 96 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , …”

Section: Resultsmentioning

confidence: 99%

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Risk of Subsequent Stroke Among Patients Receiving Outpatient vs Inpatient Care for Transient Ischemic Attack

et al. 2022

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“…The percentage of patients with cardioembolic stroke remained stable, but the percentage of patients with an undetermined cause who experienced stroke recurrence increased with time after TIA. 22…”

Section: Discussionmentioning

confidence: 99%

Incidence, predictors, and etiology of subsequent ischemic stroke within one year after transient ischemic attack

Uehara

Minematsu

Ohara

et al. 2016

International Journal of Stroke

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Background Incidence and predictors of ischemic stroke in patients with transient ischemic attack (TIA) have not been fully clarified outside Europe and North America. Aims We undertook the present prospective, multicenter study to clarify the incidence, predictors, and etiology of ischemic stroke within one year of TIA onset in Japan. Methods The study subjects were patients within seven days of TIA onset who were enrolled in a prospective register from 57 hospitals between June 2011 and December 2013. The primary endpoint was occurrence of ischemic stroke. Results Of 1365 consecutive patients, 1245 were followed for one year after TIA onset; 101 (8.1%) experienced ischemic stroke during follow-up. The leading subtype of ischemic stroke was small-vessel occlusion (SVO) followed by large-artery atherosclerosis (LAA) attributable to intracranial artery diseases. When dividing ischemic stroke events between those occurring within the first 90 days after TIA onset and those occurring after the first 90 days, the leading subtype of ischemic stroke within the first 90 days after TIA onset was SVO, followed by LAA attributable to intracranial artery diseases. In comparison, the subtypes most commonly seen beyond the first 90 days after TIA onset were cardioembolic and LAA attributable to intracranial artery disease. The one-year risk of ischemic stroke increased significantly as ABCD score increased, at 6.2% for 0-3 points, 7.2% for 4-5 points, and 11.6% for 6-7 points. Conclusions The one-year ischemic stroke risk after TIA was about 8% and was associated with the ABCD score. The most common subtype of subsequent ischemic stroke was SVO.

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How predictors and patterns of stroke recurrence after a TIA differ during the first year of follow-up

Cited by 10 publications

References 31 publications

Predictors of Stroke Events in Patients with Transient Ischemic Attack Attributable to Intracranial Stenotic Lesions

Predictors of Stroke Events in Patients with Transient Ischemic Attack Attributable to Intracranial Stenotic Lesions

Risk of Subsequent Stroke Among Patients Receiving Outpatient vs Inpatient Care for Transient Ischemic Attack

Incidence, predictors, and etiology of subsequent ischemic stroke within one year after transient ischemic attack

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