There is an increasing pressure on Higher Education Institutions (HEIs) to produce societally relevant and impactful research, and to actively engage with non-academic stakeholders who are looking for answers to their challenges. This is a special challenge for social sciences, such as business, management, entrepreneurship, as opposed to natural sciences that rely largely on quantifiable data and statistics. The present chapter addresses this challenge and introduces the dimensions of societal impact of research produced by HEIs and describes the mechanism through which HEIs can provide impactful research needed for economic competitiveness and societal well-being. Illustrations are offered on how HEIs can boost their ability to transform the results of academic and applied research into beneficial knowledge and management practice for stakeholders, including business, industry, economy and civil society at large. The chapter sheds light on how to reinforce collaboration with non-academic stakeholders and partners within research and innovation ecosystems. To support the HEI’s work, a framework for managing research with societal impact in HEIs is proposed.