HOX-7 suppresses body weight gain and adipogenesis-related gene expression in high-fat-diet-induced obese mice

Abstract

BackgroundHOX-7 is a newly developed dietary formula composed of traditional oriental herbal medicines. The formula was developed with the aim of improving weight control. We investigated the anti-obesity effect of HOX-7 on high-fat-diet (HFD)-induced obesity in C57BL/6 mice.MethodsThe mice were divided into four groups and were fed a normal diet (ND), HFD, or HFD with oral administration of HOX-7 at 100 or 200 mg/kg/day for 12 weeks. Body and fat weight, histological changes of fat tissue, and the expression of key adipogenic transcription factors were investigated.ResultsThe body weight of mice fed the HFD with HOX-7 was significantly decreased compared to the HFD group. There were no obvious differences in weekly food intake among the 4 groups. The weight of the epididymal and total fat pads was reduced in mice fed the HFD with HOX-7. Treatment with HOX-7 also substantially attenuated the expression of key adipogenic transcription factors, including peroxisome proliferatoractivated receptor γ, CCAAT/enhancer binding protein α, sterol regulatory element binding protein 1c, adipocyte P2, liver X receptor, and lipoprotein lipase in the epididymal adipose tissue.ConclusionOverall, this study highlighted the anti-obesity effects of HOX-7, a finding that could contribute to the development of natural anti-obesity herbal medicines.

A water soluble extract of radish greens ameliorates high fat diet-induced obesity in mice and inhibits adipogenesis in preadipocytes

“…Obesity is related to a complex process regulated by adipogenic transcription factors. 44 In this study, we showed that WERG treatment significantly downregulated the expression of lipogenesis-related genes, like SREBP1 and ChREBP. These factors can bind to the transcription genes of lipogenic proteins such as FAS and Acetyl-CoA carboxylase (ACC).…”

Genome-wide association study identified genes associated with ammonia nitrogen tolerance in Litopenaeus vannamei

“…HOX7 is a member of the HOX gene family, which encodes transcription factors that regulate cell division ( Zou and Jiang, 2008 ). HOX genes specify cell fates in animal embryos, and influence body weight gain ( Lee et al, 2014 ). UPF2 is a conserved nonsense-mediated mRNA decay factor.…”

Oral administration of berberine represses macrophage activation-associated benign prostatic hyperplasia: a pivotal involvement of the NF-κB

“…Specific rat and human primers were designed, which are shown in Table 1 . Quantitative real-time polymerase chain reaction (qRT-PCR) was performed as previously described [ 25 ].…”