HPLC–DAD Method for Simultaneous Determination of Dipyrone (Metamizole) and Caffeine in Tablets and Identification of Major Degradation Product by Direct Infusion ESI–MS

Vieira, James Cabral; Sversut, Rubia Adriele; Maciel, Isadora Theodoro; Carollo, Aline Regina Hellmann; Amaral, Marcos Serrou do; Kassab, Nájla Mohamad

doi:10.1007/s10337-017-3263-9

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…Judging by the methods of analysis of medicinal substances based on the materials of the original articles, we can say that chromatographic methods of analysis are still in the lead. Electrochemical methods for the analysis of medicinal substances by the number of publications rank third, behind photometry and spectrophotometry, with ∼20% of works devoted to the electrochemical determination of medicinal substances [14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

et al. 2022

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The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the metamizole-selective electrode have been determined. The expediency of the proposed design of the metamizole selective electrode for the determination of metamizole in dosage forms has been substantiated. The best composition of the membrane (wt.%) of the metamizole-selective electrode has corresponded to: ODAH+MT−—5.3; 2-nitrophenyloctylether—63.1; poly(vinyl chloride)—31.6. Electrode-active component in the membrane phase functions as an ion associate ODAH+MT−. Potentiometric characteristics of metamizole-selective electrode have been determined, which corresponded to: linear range 1 × 10−2–1 × 10−4 with limit of detection 4.58 × 10−5 M, electrode function slope −48.5 mV/dec., working interval pH 4.5–7.3, response time 60 s. The potentiometric coefficients of selectivity of the metamizole-selective electrode with respect to various ions have been determined. The possibility of determining metamizole in a medicinal product has been tested. The results of the analyses show good agreement between the two methods (relative error less than 7.0%) with coefficients of variation less than 5% for MT-SE and iodometric methods.

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Section: Introductionmentioning

confidence: 99%

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

et al. 2022

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“…Therefore, interest to analytical methods for Dip (table S1 is available online at stacks.iop.org/MAF/ 9/015001/mmedia) has been maintained during the recent years [24,[33][34][35]46]. Dip was determined by electrochemical [18][19][20][21][22][23][24], chromatographic [25][26][27][28][29][30]47] and spectroscopic [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] methods. A number of tests for Dip in single or multi-component pharmaceutical formulations have been developed using intrinsic UV absorption [31][32][33][34][35] or reactions with chemiluminescent [36][37][38], fluorescent [39], and spectrophotometric detection [40][41][42]…”

Section: Introductionmentioning

confidence: 99%

Non-covalent binding and selective fluorescent sensing of dipyrone with a carbocyanine dye and cetyltrimethylammonium bromide

Zakharenkova¹,

Kriveleva²,

Katkova³

et al. 2021

Methods Appl. Fluoresc.

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The work is aimed at the search of selective fluorescent sensors without using specific artificial receptors, antibodies, enzymes etc. With this end in view, methods based on non-covalent binding of target analytes are sought. We observed dramatic changes in the emission spectrum of a carbocyanine dye in a micellar surfactant solution (cetyltrimethylammonium bromide, CTAB) in the presence of dipyrone (metamizol, analgin): the 480 nm band intensity increases with a simultaneous decrease in intensity in near-IR region (720 nm). MALDI and NMR-1H data show the intact molecules of dipyrone and the dye. The detection can be performed in the presence of other organic species and inorganic salts. Dipyrone testing is feasible within 5 × 10–7–5 × 10–4 M with RSDs of 3.5% by using a visualizer instead of a spectrofluorimeter.

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A multidisciplinary approach to the environmental problem of emerging pollution: Synthesis and application of a novel composite photocatalyst and the case study of salbutamol degradation

Alberti,

Rucco,

Di Carro

et al. 2023

Journal of Environmental Chemical Engineering

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HPLC–DAD Method for Simultaneous Determination of Dipyrone (Metamizole) and Caffeine in Tablets and Identification of Major Degradation Product by Direct Infusion ESI–MS

Cited by 8 publications

References 11 publications

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

Non-covalent binding and selective fluorescent sensing of dipyrone with a carbocyanine dye and cetyltrimethylammonium bromide

A multidisciplinary approach to the environmental problem of emerging pollution: Synthesis and application of a novel composite photocatalyst and the case study of salbutamol degradation

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