Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR‐20a

Sun, Hongping; Wang, Qunying; Yuan, Gang; Quan, Jingzi; Dong, Dongfang; Lun, Yue; Sun, Bo

doi:10.1002/jcla.23235

Cited by 15 publications

(11 citation statements)

References 39 publications

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“…Zhang et al 24 reported that circLARP4 can facilitate the expression of miR‐424‐5p target LATS1 and YAP by acting as a sponge of miR‐424‐5p. Another research displayed that hsa_circ_001649 restrained GC by sponging miR‐20a and then inactivated Wnt/β‐catenin and ERK pathways 25 . CiRS‐7 was also reported to be significantly upregulated in GC tissues and linked to poor survival 18 .…”

Section: Discussionmentioning

confidence: 99%

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance

Shi

Song

Ding

2021

Clinical Laboratory Analysis

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Background Circular RNAs (circRNAs) are a novel family of endogenous RNAs. Recent studies have demonstrated that circRNAs are potential novel biomarkers for diagnosing cancers. However, little is known about the role of circRNAs in gastric cancer (GC). This study aimed to identify the relationship between GC and a new circRNA named hsa_circ_001888. Methods Hsa_circ_001888 expression levels were measured by quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) in GC cell lines, tissues, and plasma samples. Then, the associations between the expression level of hsa_circ_001888 and the clinicopathological features of patients with GC were further investigated. A receiver operating characteristic (ROC) curve was generated to evaluate the diagnostic value of hsa_circ_001888. Results In this study, hsa_circ_001888 was first found to be significantly downregulated in GC cell lines (AGS and MKN‐45), tissues, and plasma samples compared to control samples. Clinicopathological features showed that the expression of hsa_circ_001888 in GC tissues was associated with differentiation and in GC plasma linked with serum CEA and CA19‐9 levels. The areas under the ROC curves of hsa_circ_001888 in tissues and plasma were 0.654 and 0.66, respectively. Conclusions Hsa_circ_001888 may serve as a potential biomarker in the diagnosis of GC and may be involved in GC development.

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Section: Discussionmentioning

confidence: 99%

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance

Shi

Song

Ding

2021

Clinical Laboratory Analysis

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“…45 In lung cancer, circ-SHPRH plays an antitumor role by downregulating the expression of tumor-promoting miRNAs, miR-331-3p and miR-8-5p. 45 The miRNAs that can be absorbed by circ-SHPRH are shown in Figure 2.…”

Section: Circ-shprhmentioning

confidence: 99%

“… 44 For example, circ-SHPRH can inhibit the expression of Wnt3A and β-catenin by downregulating miR-20a, thereby inhibiting the proliferation, migration, and invasion of gastric cancer cells. 45 In lung cancer, circ-SHPRH plays an antitumor role by downregulating the expression of tumor-promoting miRNAs, miR-331-3p and miR-8-5p. 45 The miRNAs that can be absorbed by circ-SHPRH are shown in Figure 2 .…”

Section: Formation and Function Of Circ-shprhmentioning

confidence: 99%

“… 45 In lung cancer, circ-SHPRH plays an antitumor role by downregulating the expression of tumor-promoting miRNAs, miR-331-3p and miR-8-5p. 45 The miRNAs that can be absorbed by circ-SHPRH are shown in Figure 2 .

Figure 2 MicroRNAs that can be sponged by circ-SHPRH or genes and proteins associated with circ-SHPRH, according to published reports on human cancer.…”

Section: Formation and Function Of Circ-shprhmentioning

confidence: 99%

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The Emerging Role of Circ-SHPRH in Cancer

Tang

et al. 2021

OTT

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Purpose: Circ-SHPRH is a circular RNA that can regulate the expression of target genes by sponging microRNAs (miRNAs) or translating tumor suppressor proteins. Recent studies have suggested that circ-SHPRH may play a role in the development of tumors and cancers. Hence, this paper aimed to review the biological characteristics, molecular mechanisms, and potential clinical significance of circ-SHPRH in a variety of tumors and to evaluate its potential as a new diagnostic and prognostic biomarker. Methods: Numerous experiments were performed regarding the abnormal expression of circ-SHPRH in a variety of tumors, including hepatocellular carcinoma, gastric carcinoma, non-small cell lung cancer, osteosarcoma, colorectal cancer, cholangiocarcinoma, pancreatic ductal adenocarcinoma, retinoblastoma, and glioblastoma. Results: Upregulation of circ-SHPRH reportedly inhibits tumor cell proliferation, migration, and invasion, leading to the inhibition of tumor development. The clinicopathological parameters and the functional characteristics of circ-SHPRH in multiple human tumors and cancers were summarized. Circ-SHPRH functions as a tumor suppressor gene and has great potential as a diagnostic and prognostic biomarker for different types of cancer.

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“…Decreased miR-20a expression was shown to inhibit Wnt/β-catenin and RAS/RAF/ERK/MAPK signaling pathways. This, in turn, led to inhibition of growth, as well as the invasive and migratory properties of GC cells by in vitro experiments [33].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers

et al. 2020

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Gastric cancer (GC) is one of the most common and difficult diseases to treat. The study of signaling pathway regulation by microRNA provides information on the mechanisms of GC development and is the basis for biomarker creation. In this study, a circuit of microRNA interactions with signaling pathways was constructed. The microRNAs, associated with metastasis and chemoresistance, are described. In most cases, microRNAs in GC regulate the Wnt/β-catenin, PI3K/AKT/mTOR, RAS/RAF/ERK/MAPK, NF-kB, TGF-β, and JAK/STAT pathways. Part of the microRNA acts on several target genes that function in different pathways. This often leads to an intensification of the induced processes. MicroRNAs have also been described that have the opposite effect on different pathways, causing different functional consequences. By acting on several target genes, or genes associated with several pathways, microRNAs can function in a signaling network. MicroRNAs associated with metastasis most often interact with the Wnt/β-catenin pathway. MicroRNAs affecting chemoresistance, in most cases, affect the regulators of apoptosis and are associated with the PI3K/AKT/mTOR pathway. The characteristics of microRNAs proposed as candidates for GC biomarkers were analyzed. The currently developed diagnostic and prognostic panels of microRNAs are also considered.

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Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR‐20a

Cited by 15 publications

References 39 publications

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance

The Emerging Role of Circ-SHPRH in Cancer

MicroRNA in Gastric Cancer Development: Mechanisms and Biomarkers

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