Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis

Liu, Ziqi; He, Qianmei; Liu, Ye; Zhang, Yangchun; Cui, Mengxing; Peng, Honghao; Wang, Yuqing; Shen, Chen; Li, Daochuan; Chen, Liping; Xiao, Yongmei; Chen, Wen; Wang, Qing

doi:10.1016/j.tox.2021.152838

Cited by 14 publications

(5 citation statements)

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“…Moreover, miRNAs have critical impacts on the regulation of gene expression and associated biological processes such as proliferation, apoptosis, tumorigenesis [ 92 ], and even cell-cell communication (as suggested via vesicle-free extracellular miRNAs) [ 93 ]. Considering this regulatory role of miRNAs, and other transcription regulatory molecules involved in the Nrf2 pathway (such as miR-365-1, miR-193b, miR-29-b1, miR-93, miR-153, miR-27-a, miR-142–5p [ 94 ], miR-21 [ 95 ], miR-144 [ 96 ], miR-125b [ 97 ], miR-181a [ 98 ], hsa_circ_0005915 [ 99 ], miR-145–5p, miR-104–5p, miR-200a [ 100 ]) may be important to evaluate CBD action which may have a great potential to change Nrf2 activity.…”

Section: The Modulatory Activity Of Cannabidiol With Respect To the N...mentioning

confidence: 99%

The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress

2022

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Section: The Modulatory Activity Of Cannabidiol With Respect To the N...mentioning

confidence: 99%

The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress

2022

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“…In addition, previous studies found that the alteration of the NRF2/NQO1 pathway in rat testicular tissue could affect sperm and steroid production ( Shi and Fu, 2019 ). NRF2 and NQO1 are also involved in the regulation of the cellular amide metabolic process, which regulates amide damage to liver function ( Gao et al, 2023 ; Liu et al, 2021 ). In addition, we also found that NQO1 expression was significantly associated with glutathione metabolism and that this pathway is used as the main regulatory target by NRF2.…”

Section: Discussionmentioning

confidence: 99%

Pan-cancer and single-cell analysis reveal the prognostic value and immune response of NQO1

Shen,

Jiang,

Yang

et al. 2023

Front. Cell Dev. Biol.

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Background: Overexpression of the NAD(P)H: Quinone Oxidoreductase 1 (NQOI) gene has been linked with tumor progression, aggressiveness, drug resistance, and poor patient prognosis. Most research has described the biological function of the NQO1 in certain types and limited samples, but a comprehensive understanding of the NQO1’s function and clinical importance at the pan-cancer level is scarce. More research is needed to understand the role of NQO1 in tumor infiltration, and immune checkpoint inhibitors in various cancers are needed.Methods: The NQO1 expression data for 33 types of pan-cancer and their association with the prognosis, pathologic stage, gender, immune cell infiltration, the tumor mutation burden, microsatellite instability, immune checkpoints, enrichment pathways, and the half-maximal inhibitory concentration (IC50) were downloaded from public databases.Results: Our findings indicate that the NQO1 gene was significantly upregulated in most cancer types. The Cox regression analysis showed that overexpression of the NQO1 gene was related to poor OS in Glioma, uveal melanoma, head and neck squamous cell carcinoma, kidney renal papillary cell carcinoma, and adrenocortical carcinoma. NQO1 mRNA expression positively correlated with infiltrating immune cells and checkpoint molecule levels. The single-cell analysis revealed a potential relationship between the NQO1 mRNA expression levels and the infiltration of immune cells and stromal cells in bladder urothelial carcinoma, invasive breast carcinoma, and colorectal cancer. Conversely, a negative association was noted between various drugs (17-AAG, Lapatinib, Trametinib, PD-0325901) and the NQO1 mRNA expression levels.Conclusion: NQO1 expression was significantly associated with prognosis, immune infiltrates, and drug resistance in multiple cancer types. The inhibition of the NQO1-dependent signaling pathways may provide a promising strategy for developing new cancer-targeted therapies.

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“…Numerous procedures above documented have been used for syntheses with other amides as sources of building blocks; others could also be efficient. Another remark concern the alarm to the potential safety hazards associated with using DM in particular chemical conditions [161,162] and the toxicity of these solvents [163].…”

Section: Discussionmentioning

confidence: 99%

A Journey from June 2018 to October 2021 with N,N-Dimethylformamide and N,N-Dimethylacetamide as Reactants

Мuzart¹

2021

Molecules

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Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis

Cited by 14 publications

References 47 publications

The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress

The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress

Pan-cancer and single-cell analysis reveal the prognostic value and immune response of NQO1

A Journey from June 2018 to October 2021 with N,N-Dimethylformamide and N,N-Dimethylacetamide as Reactants

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