HTLV-III/LAV Infection in Nine Children Infected by a Single Plasma Donor: Clinical Outcome and Recognition Patterns of Viral Proteins

Lange, Joep M. A.; Berg, Henk van den; Dooren, L. J.; Vossen, Jaak M.; Kuis, Wietse; Goudsmit, Jaap

doi:10.1093/infdis/154.1.171

Cited by 43 publications

(13 citation statements)

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“…A general policy for advising against breast-feeding could have serious consequences for developing countries. Several case reports have described acquired immunodeficiency in infants for whom the only known risk factor was neonatal transfusion from an individual later found to be suffering from AlDS (Lange et al 1986;Amman et a/. 1983).…”

Section: Perinatal Acquisitionmentioning

confidence: 99%

Obstetric and perinatal consequences of human immunodeficiency virus (HIV) infection: a review

Peckham

Senturia

Ades

1987

BJOG

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Section: Perinatal Acquisitionmentioning

confidence: 99%

Obstetric and perinatal consequences of human immunodeficiency virus (HIV) infection: a review

Peckham

Senturia

Ades

1987

BJOG

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“…HIV infection resulting from blood transfusion has been documented repeatedly since the first case report from the United States in late 19825. The problems of transfusion associated acquired immuno deficiency syndrome resulted in a notification in 1989 under the Drugs and Cosmetics Act which made the test for HIV mandatory6.…”

mentioning

confidence: 99%

Prevalence of HIV among blood donors in a tertiary care centre of north India

et al. 2011

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Background & objectives:India has the second highest HIV population in the world with about 2.5-3.0 million cases. HIV-2 cases among general and blood donor population have also been reported mostly from west and south India. This single centre study was carried out to observe the HIV-1 and HIV-2 prevalence among blood donors from north India.Methods:A total of 2,04,677 people were screened for the presence of HIV infection over the 11 year period (1999 to 2009). Till 2004, a third generation ELISA kit was used. From 2005 till January 2009 all tests were done using the fourth generation ELISA kit which detected the presence of HIV-1 P24 antigen and anti-HIV antibodies. From February 2009 onwards, the kits used were Genscreen ULTRA HIV Ag-Ab Assay.Results:A total of 506 (0.247%) donors were found to be repeat reactive for HIV. Of these, 486 (96%) donors tested using the Western blot were found positive for HIV-1 infection. Twenty (4%) donors showed a negative Western blot result, none of the donors were found reactive for HIV-2 infection.Interpretation & conclusions:The prevalence of HIV was 0.249 per cent among blood donors of north India. No HIV-2 case was found among the studied blood donor population indicating that it is not a threat currently.

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“…Sequential PBMCs were taken from six children who had been infected with HIV-1 by one or more transfusions of plasma from one donation of a single donor between April and November 1981 (20).…”

mentioning

confidence: 99%

Evolution of sequences encoding the principal neutralization epitope of human immunodeficiency virus 1 is host dependent, rapid, and continuous.

Wolfs

Jong

Berg

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

131

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The principal neutralization epitope of human immunodeficiency virus 1 is localized in the third variable (V3) domain of the external envelope and has been shown to bind isolate-specific antibodies. Therefore, the extent of variation within the nucleic acid sequence encoding this epitope was studied in DNA directly obtained from peripheral blood mononuclear cells of six children and their plasma donor. This revealed that the quasi-species distribution of sequences obtained after cloning varied from recipient to recipient and that the distance from the donor sequences increased over time. V3 nucleotide evolution rates averaged 9.5 X 10-3 per site per year for silent sites and 11.4 X 10-per site per year for nonsilent sites (vs. 9.7 and 9.8 x 10-3 per site per year for a control region 5' adjacent to the V3 region) and, although individual differences were observed, did not correlate with the serum antigen levels or disease progression. Sequences of both the epitope coding region itself (V3) and the control region upstream diverted more from the donor sequence among children not progressing to AIDS than among children progressing to AIDS. The evolution of V3 sequences is apparently host dependent, rapid, and independent of the level of antigen expression.The third hypervariable region (V3) of the human immunodeficiency virus 1 (HIV-1) envelope glycoprotein gpl20 contains a neutralization epitope that is highly antigenic (1-4). Antibodies binding to the amino acid stretch between amino acids 307 and 321 exhibit isolate-specific virus-neutralizing and cell fusion-inhibiting activities (1-7). Moreover, Takahashi et al. (8,9) showed that the V3 region encompasses a major histocompatibility complex class I-restricted isolatespecific determinant for cytotoxic T lymphocytes (CTLs

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HTLV-III/LAV Infection in Nine Children Infected by a Single Plasma Donor: Clinical Outcome and Recognition Patterns of Viral Proteins

Cited by 43 publications

References 0 publications

Obstetric and perinatal consequences of human immunodeficiency virus (HIV) infection: a review

Obstetric and perinatal consequences of human immunodeficiency virus (HIV) infection: a review

Prevalence of HIV among blood donors in a tertiary care centre of north India

Evolution of sequences encoding the principal neutralization epitope of human immunodeficiency virus 1 is host dependent, rapid, and continuous.

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