Prevalence of HIV among blood donors in a tertiary care centre of north India

Abstract

Background & objectives:India has the second highest HIV population in the world with about 2.5-3.0 million cases. HIV-2 cases among general and blood donor population have also been reported mostly from west and south India. This single centre study was carried out to observe the HIV-1 and HIV-2 prevalence among blood donors from north India.Methods:A total of 2,04,677 people were screened for the presence of HIV infection over the 11 year period (1999 to 2009). Till 2004, a third generation ELISA kit was used. From 2005 till January 2009 all tests were done using the fourth generation ELISA kit which detected the presence of HIV-1 P24 antigen and anti-HIV antibodies. From February 2009 onwards, the kits used were Genscreen ULTRA HIV Ag-Ab Assay.Results:A total of 506 (0.247%) donors were found to be repeat reactive for HIV. Of these, 486 (96%) donors tested using the Western blot were found positive for HIV-1 infection. Twenty (4%) donors showed a negative Western blot result, none of the donors were found reactive for HIV-2 infection.Interpretation & conclusions:The prevalence of HIV was 0.249 per cent among blood donors of north India. No HIV-2 case was found among the studied blood donor population indicating that it is not a threat currently.

The Prevalence of Transfusion-Transmitted Infections (TTIs) and Distribution Pattern of ABO Rh Blood Group in Blood Donors and Possible Correlation of TTIs with ABO and Rh Blood Groups – A Study at RBTC (North-West) Delhi

“…The seropositivity of syphilis was only 0.027% similar to a study by Sinha and Dey 10 in which they found seroprevalence of 0.015%, that was much less as compared to the other studies by Makroo et al, 4 Prabhakar et al, 14 and Singh et al 12 who found a prevalence of 0.23%, 0.22% and 0.5% respectively in their studies. Though treponema pallidum does not survive in the stored blood, but it is considered a lifestyle marker as persons positive for syphilis are also likely to be having other sexually transmitted diseases.…”

Seroprevalence of Hiv and HBsAg among Blood Donors of a Tertiary Care Hospital:A Cross Sectional Study from Khammam, Andhra Pradesh

“…Some researches shows seroprevalence of HIV was 0.44%, 0.54% and 0.56% [22,28,29]. Makroo et al in 2011 reported 0.24% among blood donors [30]. In this study we observed relatively less case (0.04%) of HIV.…”

Transfusion transmitted infections in thalassaemics: need for reappraisal of blood screening strategy in India

“…For the third generation ELISA 98·5 and 99·3% for fourth generation assay were repeat reactives. Of the repeat reactives 96% were confirmed positive by the HIV‐1 WB (Makroo et al , ). In a small size ( n = 1075) comparative study, four additional seroreactive samples were observed by the fourth generation assay over the third generation, with only one of the four confirmed by WB (Kaur et al , ).…”