This study aims to produce valid, practical and effective comic-assisted electronic teaching materials to increase students' interest in learning. This research is a developmental research using the ADDIE model and was tested on 29 students in class XI MIPA 1 at a senior high school in Banjarmasin. Data collection techniques used validation sheets, student response questionnaires, learning interest questionnaires and learning achievement tests. The results of the teaching materials show that: (1) Validation scores 3.43 in the very good category, (2) Practicality scores 3.14 in the practical category, (3) Effectiveness scoresn-gain 0.69 with medium category. Students' interest in learning has increased by using comic-assisted electronic teaching materials.