Hubungan Lama Terapi Antipsikotik dengan Kadar SGOT dan SGPT pada Pasien Skizofrenia di RSJ Prof. H.B Sa’anin, Padang Tahun 2013

Cahyaningtyas, Cahyaningtyas; Rahmatini, Rahmatini; Sedjahtera, Kurniawan

doi:10.25077/jka.v6i1.658

Cited by 3 publications

(6 citation statements)

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“…There was no significant correlation between the duration of antipsychotic drug administration (1-6 months or more than 6 months) and transaminitis, which comes in line with Cahyaningtyas et al's finding that there was no significant association between short-term (≤ 6 months) and long-term (> 6 months) antipsychotic therapy and AST and ALT levels (Cahyaningtyas et al, 2017;Indira et al, 2017). Furthermore, our results support Atasoy et al's findings in absence of a statistically significant difference in the frequency of asymptomatic high liver enzyme in patients who received AD for shorter (< six months) or longer duration beyond six months (Atasoy et al, 2007).…”

Section: Discussionsupporting

confidence: 59%

“…Certain psychiatric disorders need long-term drug therapy, and the long-term use of antipsychotic drugs (AD) is correlated with a high risk of drug side effects, particularly DILI. Although there have been some studies that have investigated the association between the use of AD and impaired liver function, as well as the duration of drug use for these disorders, there is still a lot of inconsistency in the data (Cahyaningtyas et al , 2017; Yulianty et al , 2017; Anjelisa and Ruhi, 2018). Our study aimed to evaluate the impact of AD on serum transaminases in patients with psychiatric disorders, particularly the elevation of AST and ALT levels.…”

Section: Introductionmentioning

confidence: 99%

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Elevated liver transaminases among patients with psychiatric disorders

Ali,

Abdel Maksoud,

Arafa

et al. 2024

International Clinical Psychopharmacology

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Hepatocyte injury is assessed by serum aspartate transaminase and alanine transaminase estimation. In psychiatric populations, antipsychotic drugs (AD) are culprit in hepatic dysfunction. To assess transaminitis among psychiatric patients treated by AD. This cross-sectional study was conducted in Zagazig University Hospitals in Egypt, from December 2022 to February 2023. A total of 135 adult patients aged ≥ 18 years, were diagnosed with psychiatric disorders after exclusion of patients receiving any hepatotoxic drugs, viral hepatitis, having chronic liver or kidney diseases, diabetes mellitus, mental retardation, and pregnant females. Among the 135 patients, 104 (77.0%) were males. Their age was 32 ± 9, The most popular used class of AD was atypical AD 84 (62.2%). The overall incidence of transaminitis among patients receiving AD was 23/135 (17.04%) of patients; 13 (56.5%) were on atypical AD compared to 10 (43.5%) patients receiving combined AD, without any statistically significant difference. The use of AD in patients with psychiatric disorders is potentially safe with minimal transaminitis (<one-fold elevation). However, baseline and regular monitoring of serum aminotransferase is recommended during treatment.

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Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Elevated liver transaminases among patients with psychiatric disorders

Ali,

Abdel Maksoud,

Arafa

et al. 2024

International Clinical Psychopharmacology

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“…22,23 The data showed that the antipsychotic therapy duration 1-6 months and >6 months did not have a significant relationship with AST and ALT levels. This is consistent with Cahyaningtyas et al 13 which stated that there was no significant relationship between the duration of short-term (≤ 6 months) and long-term (> 6 months) combination of antipsychotic therapy with AST and ALT levels. 18 .…”

Section: Discussionsupporting

confidence: 91%

“…12 However, the results of this study are different from the other study stated that the levels of AST and ALT had no significant relationship with the duration of short and long-term antipsychotic therapy. 13 Schizophrenia is included in the top 10 mental disorders that require long-term pharmacotherapy. Long-term use of antipsychotics increases the risk of drug side effects, especially DILI, but this is not routinely monitored and evaluated.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Antipsychotic Drug Use and Liver Enzyme Levels in People with Mental Disorders

Meiyanti

Mulia

Pusparini

2022

J. Drug Delivery Ther.

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The long-term use of some drugs causes side effects in the form of elevated liver enzyme levels. Meanwhile, antipsychotic drug therapy in people with mental disorders induces liver injury which leads to an elevation in serum glutamic oxaloacetic and pyruvic transaminases. Therefore, this study aims to analyze the relationship between the uses of antipsychotic drugs with elevated liver enzymes in people with mental disorders. This observational study used a cross-sectional design that included 69 people with mental disorders. The respondents were selected based on consecutive non-random sampling, while the data were collected using a questionnaire to obtain the universal characteristics of the subjects, therapy duration, and antipsychotic type, as well as an examination of AST and ALT levels using the ultraviolet test method. Furthermore, data analysis was conducted using the chi-Square test with a significance level of p<0.05. The results showed that thirty-two among the respondents or 46.4% used atypical antipsychotics, while 37 or 73.0% received the drugs for 1-6 months. In the subjects receiving typical antipsychotics, 10 or 55.6% had a significant elevation in liver enzymes compared to others receiving atypical antipsychotics namely 6 (18.8%) or a combination of both drugs namely 6 (31.6%). Therefore, the type of antipsychotic used in therapy has a significant relationship with elevated liver enzymes in people with mental disorders (p=0.028). Keywords: antipsychotics, drugs, elevated

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“…Penggunaan obat dalam jangka panjang dapat menyebabkan kerusakan fungsi ginjal dan memperberat kerja ginjal sehingga menyebabkan ginjal tidak lagi berfungsi dengan baik. Antipsikotik adalah obat medis yang digunakan untuk mengobati gangguan mental, obat yang dikonsumsi pasien gangguan jiwa dapat menyebabkan toksisitas Cahyaningtyas et al (2013). Setelah dilakukan observasi di Rumah Sakit Jiwa Mutiara Sukma Provinsi NTB, diperoleh data sebanyak 285 orang dengan gangguan jiwa yang diperiksa kadar kreatininnya dari bulan Januari sampai dengan oktober tahun 2020.…”

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Study of Creatinin Levels of Patients Receiving Antipsycotic Treatment at Mutiara Sukma Psychiatric Hospital, Nusa Tenggara Barat

Sukmana

Mentari

Anjelin

2021

medicra

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Mental disorders are clinical and social problems that must be addressed immediately. Long-term use of the drug can cause damage to kidney function and worsen the work of the kidneys. Creatinine is a waste product of creatine phosphate metabolism that occurs in the muscles and is then released into the blood circulation, then transported to the kidneys. The purpose of this study was to determine how the creatinine levels of mental patients receiving antipsychotic treatment at Rumah Sakit Jiwa Mutiara Sukma Hospital, Nusa Tenggara Barat Province. The research method used is qualitative. The type of research used is descriptive, namely looking at data from the Clinical Pathology laboratory installation and medical records to determine the results of examination of creatinine levels in patients with mental disorders. The results showed that from data in the Clinical Pathology laboratory and medical records at Rumah Sakit Jiwa Mutiara Sukma, NTB Province from June-December 2020 with a total of 40 data, there were 30 patients (75%) who had normal creatinine levels, 2 patients (5%) had normal creatinine levels. creatinine levels were low, and 8 patients (20%) had high creatinine levels.

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Hubungan Lama Terapi Antipsikotik dengan Kadar SGOT dan SGPT pada Pasien Skizofrenia di RSJ Prof. H.B Sa’anin, Padang Tahun 2013

Cited by 3 publications

References 0 publications

Elevated liver transaminases among patients with psychiatric disorders

Elevated liver transaminases among patients with psychiatric disorders

The Relationship between Antipsychotic Drug Use and Liver Enzyme Levels in People with Mental Disorders

Study of Creatinin Levels of Patients Receiving Antipsycotic Treatment at Mutiara Sukma Psychiatric Hospital, Nusa Tenggara Barat

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