Human antibodies against antigens of the sparrow, blackbird, weaver finch, canary, budgerigar, pigeon and hen using the indirect immunofluorescent technique

Sennekamp, J.; Lange, G. G. G. De; Nerger, K; Berdel, Dietrich; Meier-Sydow, J

doi:10.1111/j.1365-2222.1981.tb01608.x

Cited by 20 publications

(14 citation statements)

References 5 publications

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“…Of note, several amino acid residues highly conserved only among birds were observed in the N-terminal domain (Additional file 3: Figure S3). This specificity to birds may explain the cross-reactivity of patient sera to other unexposed avian species [24]. Our result is therefore consistent with the speculation from Mcsharry et al that immunoglobulin light chain may cause the BRHP.…”

Section: Discussionsupporting

confidence: 92%

Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

et al. 2017

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BackgroundAvian antigen is a common cause of hypersensitivity pneumonitis (HP). Inhalation challenge with pigeon serum and pigeon dropping extract (PDE) elicits a hypersensitivity reaction in patients with bird-related hypersensitivity pneumonitis (BRHP), but the antigenic components in these materials have yet to be fully elucidated.MethodPigeon serum, pigeon intestine homogenates, and PDE were immunoblotted with serum samples from 8 patients with BRHP, 2 patients with summer-type HP, 2 patients with humidifier lung, and 3 healthy volunteers. Among the protein spots found in both pigeon serum and PDE, those that reacted with sera from BRHP patients were identified by mass spectrometry. Immunoassays using recombinant protein were performed to confirm the antigenicity of the identified protein. Cytokine production by peripheral blood mononuclear cells (PBMCs) stimulated with recombinant protein was also assessed.ResultsImmunoglobulin lambda-like polypeptide-1 (IGLL-1) was identified from all spots on 2-DE immunoblots of both pigeon serum and PDE. The BRHP patients exhibited higher levels of serum IgG antibody against the recombinant IGLL-1 (rIGLL-1) compared to the control subjects, as well as a stronger PBMCs proliferative response to rIGLL-1. Cytokine production by PBMCs from BRHP patients after rIGLL-1 exposure indicated that the protein could induce Th1 prone immune responses: an increase in TNF-α and an absence of elevated IL-10 production.ConclusionsPigeon IGLL-1 was identified as the BRHP antigen present in both pigeon serum and PDE.Electronic supplementary materialThe online version of this article (doi:10.1186/s12931-017-0555-4) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 92%

Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

et al. 2017

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“…The sera of many avian species have proteins with antigenic identity [ 65, 66] which could explain the positive precipitin reactions to pigeon serum in subjects with exposure to other avian species, or in patients with inflammatory bowel disease e.g. coeliac disease in which serum antibody against avian antigens is caused by immune responses to ingested hens' egg proteins [ 66].…”

Section: Disease Spectrum Associated With Pigeonsmentioning

confidence: 99%

A review of antigen diversity causing lung disease among pigeon breeders

McSharry

Anderson

Boyd³

2000

Clin Experimental Allergy

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“…One of our patients, who started with asthma due to her budgerigar at the age of 42 and subsequently developed egg allergy, was ex clusively sensitized against bird feathers, egg-white and egg-yolk proteins, and made us aware that a simi lar cross-reactivity might exist for hen's eggs and other avian antigens. Indeed IgG antibodies against egg-yolk proteins have been described in workers ex posed to egg spray [13,14,30] and recent research on extrinsic allergic alveolitis (pigeon's breeder lung) demonstrated cross-reactivity of precipitating anti bodies to bird antigens among several species [19,20] and with the water-soluble egg-yolk proteins known as 'livetins' [21][22][23]. However, only 1 patient with asthma was recently reported to have parrot-specific IgE antibodies cross-reacting with crude egg-yolk ex tracts [24], The present paper describes the results obtained in 59 atopic adults systematically skin tested with budgerigar and canary feathers, egg white, egg yolk and pure livetin extracts and all the common pneumo-allergens.…”

Section: Introductionmentioning

confidence: 99%

Bird-Egg Syndrome

Mandallaz

Weck

Dahinden³

1988

Int Arch Allergy Immunol

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87 adult patients from our allergy clinic were skin tested with budgerigar and canary feathers, hen’s egg white and egg yolk and common inhalant allergens. Of 59 patients found to be atopic, 17 (29%) were concomitantly sensitized to bird dander and egg proteins, 10 of them being symptomatic to bird dander and/or egg exposure. All but 1 of the egg-symptomatic patients were exposed to pet birds. The patients with strong serological reactivity to bird antigens were also exclusively sensitized to egg proteins, in particular to livetins (water-soluble fractions of egg-yolk proteins). Extensive RAST-inhibition studies demonstrated identical patterns of cross-reactivity between bird dander and hen’s egg proteins, livetins being the major cross-reacting antigens. This peculiar IgE-mediated allergy is designated as ‘bird-egg syndrome’. It is suggested that egg intolerance in adults is mainly due to sensitization to egg-yolk livetins and can be provoked by inhalation of pet bird dander. Thus, it must be distinguished from the common egg-white allergy of atopic children. Our study further underlines the importance of respiratory sensitization in adult food allergy. On the other hand, exposure to cross-reacting antigens by ingestion might also influence the allergic manifestations to inhalant allergens.

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Human antibodies against antigens of the sparrow, blackbird, weaver finch, canary, budgerigar, pigeon and hen using the indirect immunofluorescent technique

Cited by 20 publications

References 5 publications

Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

Protein antigen of bird-related hypersensitivity pneumonitis in pigeon serum and dropping

A review of antigen diversity causing lung disease among pigeon breeders

Bird-Egg Syndrome

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