Human Bocavirus in Patients with Encephalitis, Sri Lanka, 2009–2010

Abstract

We identified human bocavirus (HBoV) DNA by PCR in cerebrospinal fluid from adults and children with encephalitis in Sri Lanka. HBoV types 1, 2, and 3 were identified among these cases. Phylogenetic analysis of HBoV1 strain sequences found no subclustering with strains previously identified among encephalitis cases in Bangladesh.

Small circular single stranded DNA viral genomes in unexplained cases of human encephalitis, diarrhea, and in untreated sewage

“…These included 29 children aged between 2 and 144 months old and 33 adults between 15 and 72 years old. These samples had pre-tested negative for bacteria, herpes simplex virus, varicella-zoster virus, Epstein-Barr virus, cytomegalovirus, dengue virus, Japanese encephalitis virus, rubella virus, west nile virus, yellow fever virus, tick-borne encephalitis virus, nipah virus, measles virus, mumps virus, parainfluenza virus, respiratory syncytial virus, metapneumovirus, chikungunya virus, sindbis virus, semliki forest virus, eastern equine encephalitis virus, western equine encephalitis virus, poliovirus, coxsackievirus, echovirus, enterovirus, lyssaviruses, chandipura virus, bocavirus, rotavirus, astrovirus, norovirus, parechovirus, and adenovirus (Mori et al, 2013). …”

The challenge of treating central nervous system infections

“…Several hitherto unsuspected agents, such as Bocavirus and Cyclovirus, have been recently isolated in CSF of Sri Lankan patients with CNS infections. [31,32]. Furthermore, several non-infectious syndromes such as paraneoplastic and immune-mediated encephalitis are well described, and recent reports indicate that they may be at least as common as infectious causes [28,33].…”

Viruses of the Parvoviridae Family: Molecular Genetical Aspects of Reproduction and Medical Importance

“…Так, ДНК Primate bocaparvovirus 1 (генотип HBoV1) и Primate bocaparvovirus 2 (генотип HBoV2) была обнару-жена у 5,8% (4/69) детей с энцефалитом в Бан-гладеш (двое больных умерли) [54]. Описаны случаи энцефалита в Шри-Ланке (5/191), вы-званные генотипами HBoV1 (3 случая) и HBoV3 (1 случай) Primate Bocaparvovirus 1 и геновари-антом HBoV2 Primate bocaparvovirus 2 (1 слу-чай) [55]. Также ДНК HBoV2 была обнаружена у детей (3/57) с острым вялым параличом не-полиовирусной природы в Пакистане [44].…”

“…и Mori D. [54,55], у пациентов не были обнаружены IgM-антитела к HBoV1-4; IgG-антитела отсутствовали или был определен их низкий уровень.…”