Viruses of the Parvoviridae Family: Molecular Genetical Aspects of Reproduction and Medical Importance

Антипова, А. Ю.; Лаврентьева, И. Н.

doi:10.15789/2220-7619-2017-1-7-20

Cited by 3 publications

(2 citation statements)

References 86 publications

(175 reference statements)

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“…Врожденная ПВИ В19 остается актуальной проблемой в связи с высоким уровнем (до 60%) серонегативных женщин фертильного возраста и является одной из причин перинатальных потерь [2]. Частота вертикальной передачи вируса составляет около 30%, риск внутриутробной гибели плода в этих случаях достигает 10% [4].…”

Section: парвовирусная инфекция в19vunclassified

“…Частота вызываемой ими патологии не одинакова: преобладают вирусные инфекции и их сочетания. Так, антенатальная смертность при врожденных вирусных инфекциях достигает 27%, в то время как при бактериальных инфекциях этот показатель не превышает 17% [1,2,3]. В настоящее время все большую актуальность приобретает проблема вирусных инфекций, возбудители которых могут быть переданы от матери плоду, в частности вирусы семейства герпесвирусов [цитомегаловирус (ЦМВ), вирусы герпеса человека 6 и 7 типов (ВГЧ-6 и ВГЧ-7)], а также парвовирус В19 (ПВ B19) [47].…”

Section: Introductionunclassified

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Molecular genetic and clinical aspects of socially relevant viruses underlying congenital diseases

Васильев

Рогозина

Grineva³

2021

Russian Journal of Infection and Immunity

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Congenital viral infectious diseases are characterized by polyetiologic pathology holding an important place in the structure of perinatal losses. Due to the wide distribution and lack of specific prophylaxis, the problem of herpesvirus infections is of greatest interest, namely of herpes infection caused by herpes simplex virus type 1 and 2, human herpes simplex virus type 6 and cytomegalovirus infection, as well as parvovirus infection B19. The opportunities to investigate a relation between manifestations of the infectious process and host molecular genetic characteristics have been expanded after developing full genome sequencing methods and creating genetic data international banks. It has been proven that herpes virus genetic variations can account for related neurovirulence, showing that diverse cytomegalovirus genotypes are associated with hepatosplenomegaly, hearing impairment and the symptoms of the central nervous system diseases. Nevertheless, the data on correlation between genotypes and clinical manifestations are still scarce and contradictory, whereas high level of variability becomes extremely evident while comparing genomic sequences of viral strains. The herpesvirus type 6 has been proven to integrate into germ cells with potential for subsequent vertical transmission of chromosomally integrated virus to the offspring and its further intergeneration inheritance. А direct relationship between B19V genospecies and disease manifestations including congenital infections has not yet been identified. Taking into account possible differences in the geographical distribution of such viruses on the territory of the Russian Federation, ethnic populational characteristics, and high frequency of related congenital infectious diseases with a wide range of clinical manifestations, it seems promising to expand scientific research on the genotyping of herpes simplex viruses, cytomegalovirus, herpes viruses type 6 and parvovirus B19V in Russia. The results of such studies will be demanded by practical healthcare in order to develop and use more effective etiotropic drugs and specific prophylaxis in the light of trends to develop personalized and preventive medicine.

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Section: парвовирусная инфекция в19vunclassified

Section: Introductionunclassified

Molecular genetic and clinical aspects of socially relevant viruses underlying congenital diseases

Васильев

Рогозина

Grineva³

2021

Russian Journal of Infection and Immunity

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Features of the immunopathogenesis of infections caused by viroids and satellite viruses

Moskalev,

Gumilevsky,

Apchel

et al. 2024

Bulletin of the Russian Military Medical Academy

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One of the main molecular mechanisms of viroids that cause disease in plants is the blocking of ribonucleic acid functions of host cells by viroid ribonucleic acid. The variety of splicing options is due to viroid replication, which requires ribonucleic acid polymerase, ribonuclease, ligase, and deoxyribonucleic acid working on ribonucleic acid matrices. Viroids with faster replication are preferred. Identifying host proteins that interact with viroid ribonucleic acid is critical in the pathogenesis of viroid infections, which leads to gene expression changes of host plants. The study of the pathogenesis of plant infections caused by satellite viruses has shown that they have a common ancestor and that the satellite viruses suppress the reproduction of the helper virus. Satellite viruses require accessory viral proteins to encode capsid proteins for genome encapsulation and reproduction. Replication occurs in the cytoplasm and is induced by ribonucleic acid polymerase of the helper virus. Hepatitis D virus ribonucleic acid replication requires cell ribonucleic acid polymerase II. When the viral and endosomal membranes fuse, the ribonucleic acid of the hepatitis D virus moves into the nucleus, and antigenomic ribonucleic acid is produced, which is the template for the synthesis of matrix ribonucleic acids encoding delta protein. The minor delta antigen regulates ribonucleic acid editing, and the large delta antigen inhibits viral replication and induces a signal for the transport of ribonucleic acid from the cell nucleus to the cytoplasm, which ensures the assembly of new viral particles. Large and small delta antigens have been detected in the brain, liver, lungs, kidneys, and spleen of snakes by reverse transcriptase polymerase chain reaction, Western blotting, and immunohistochemical assays, indicating that all delta viruses possibly share a common ancestor that arose before the divergence of reptiles and mammals.

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Respiratory tract damage with bocavirus infection in children

2020

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Long time the main pathogens associated with the development of community-acquired pneumonia were bacteria. However, in recent years in the Russian Federation, like all over the world, the view of the damage of lower respiratory tract changed, including a unique approach to community-acquired pneumonia as a bacterial infection, and respiratory viruses have become seen as a direct cause of lower respiratory tract damage, or as part of a viral-bacterial co-infection. These studies became possible since the widespread introduction of PCR techniques in the clinical setting, identification of respiratory viruses has increased and new microorganisms such, one as human bocavirus have been discovered. Objective: to study the features of respiratory tract damage in acute bocavirus infection in children of different ages. Materials and methods: A retrospective analysis of 97 medical hospital documentation of children with acute bocavirus infection, detected confirmed by PCR in nasopharyngeal aspirate. Results: In this work, it was shown that human bocavirus spread throughout the year with an increase in the incidence of clinically significant forms in the autumnwinter period, including during the period of an increase in the incidence of influenza. HBoV infection requiring hospitals is most significant in the first three years of life. In 74.2% of hospitalized children, bocavirus infection occurs with lower respiratory tract infections in the form of bronchitis — 77.8%, pneumonia — 28.9% and rarely bronchiolitis and is complicated by the development of respiratory failure in 28.9% of cases. Changes in the blood test are non-specific, and the level of C-reactive protein in children with various clinical manifestations of HBoV infection generally does not exceed 50 mg / l. An x-ray of the chest organs does not objectively reflect the existing volume and nature of the inflammatory process in the lungs.

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Viruses of the Parvoviridae Family: Molecular Genetical Aspects of Reproduction and Medical Importance

Cited by 3 publications

References 86 publications

Molecular genetic and clinical aspects of socially relevant viruses underlying congenital diseases

Molecular genetic and clinical aspects of socially relevant viruses underlying congenital diseases

Features of the immunopathogenesis of infections caused by viroids and satellite viruses

Respiratory tract damage with bocavirus infection in children

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