2002
DOI: 10.1016/s0006-291x(02)00289-9
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Human caspase 12 has acquired deleterious mutations

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Cited by 321 publications
(256 citation statements)
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“…al. (36) reported a human caspase 12 sequence that is predicted to encode multiple splice variants and stop codons. Antibodies directed against a conserved region of the mouse protein identify a human cellular protein that is of similar relative molecular mass with appropriately sized cleavage fragments (23,34).…”
Section: Discussionmentioning
confidence: 99%
“…al. (36) reported a human caspase 12 sequence that is predicted to encode multiple splice variants and stop codons. Antibodies directed against a conserved region of the mouse protein identify a human cellular protein that is of similar relative molecular mass with appropriately sized cleavage fragments (23,34).…”
Section: Discussionmentioning
confidence: 99%
“…8,9 Caspase-12 exists in both truncated and full-length alleles in humans and as a full-length caspase in rodents. 10 Caspase-14 is expressed in the epidermis and has a primary role in cornification and protection of underlying layers of skin. 11 Based on their function, mammalian caspase-2, -3, -7, -8, -9 and -10 are apoptotic caspases, where as caspase-1, -4, -5, -11 and -12 are involved in inflammation.…”
Section: Open Questionsmentioning
confidence: 99%
“…171,172 However, it was recently shown that human caspase-4, which is 48% homologous to murine caspase-12, is localized to the ER membrane and is specifically activated by and required for ER stress-induced apoptosis. 173 These data suggest that caspase-4 is the human functional counterpart of murine caspase-12.…”
Section: Esr and Apoptosismentioning
confidence: 99%