Human Decidual Cell Biosynthesis of Leukemia Inhibitory Factor: Regulation by Decidual Cytokines and Steroid Hormones1

Sawai, Keisuke; Matsuzaki, Noboru; Okada, Takayoshi; Shimoya, Koichiro; Koyama, Masayasu; Azuma, Chihiro; Saji, Fumitaka; Murata, Yuji

doi:10.1095/biolreprod56.5.1274

Cited by 67 publications

(31 citation statements)

References 36 publications

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“…Since Lif was not expressed in decidual cells of hamsters, we suggest a possible role for circulating Lif on decidual cells. Contrary to this finding in hamsters, Lif expression in decidual cells and its regulation by decidual cytokines and E 2 has been reported in humans (Kojima et al 1994, Sawai et al 1995, 1997. It is also possible that other members of the IL-6-type cytokine family that share the use of glycoprotein gp130 may be involved in decidualization.…”

Section: Discussionmentioning

confidence: 60%

Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus)

Ding¹,

Song²,

Wang³

et al. 2007

Reproduction

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Blastocyst implantation occurs in the progesterone-primed uterus of hamsters, but not in mice where the progesterone-primed uterus requires estrogen influence. Leukemia inhibitory factor (Lif), an estrogen-regulated gene in mice, is an absolutely needed cytokine for uterine receptivity and implantation in this species. This study aimed to evaluate the importance of Lif ligand-receptor signaling during uterine receptivity and implantation in hamsters. We investigated whether or not the uterine expression patterns of Lif and its receptors, Lif-r and gp130, during the periimplantation period of pregnancy and its hormonal regulation in the ovariectomized hamster correlate with some of the vital phases of uterine changes during early pregnancy. Uterine Lif, Lif-r, and gp130 mRNA expressions were examined by Northern and in situ hybridization. During the uterine preparatory phase for implantation, Lif, Lif-r, and gp130 were expressed either in the gland, luminal epithelium or both. As the implantation process began, Lif expression was minimal, but Lif-r and gp130 extended to the decidual areas. This decidual expression of Lif-r and gp130 was not dependent on the presence of the embryo since these genes were expressed in the sutureinduced deciduomata. We also observed that, while the uterine Lif was induced by estrogen, Lif-r and gp130 were induced by progesterone in ovariectomized hamsters. Additionally, we show that a Lif antibody when instilled intraluminally on day 3 of pregnancy reduced the number of implantation sites. Taken together, these data suggest that Lif signaling is important for uterine receptivity and implantation in hamsters. Reproduction (2008) 135 41-53

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Section: Discussionmentioning

confidence: 60%

Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus)

Ding¹,

Song²,

Wang³

et al. 2007

Reproduction

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“…In humans, LIF mRNA and protein are expressed in the endometrial glands during the luteal phase of the menstrual cycle when implantation would occur (CharnockJones et al 1994, Arici et al 1995, Chen et al 1995. LIFRb and gp-130 are expressed in LE throughout the cycle in women of proven fertility (Cullinan et al 1996) but LIF mRNA and protein are also expressed in decidual stroma (Kojima et al 1994, Sawai et al 1997, Chen et al 2004 and gp-130 in decidua (Classen-Linke et al 2004). gp-130 protein has been localized to the glandular epithelium in the mid-and late-secretory phase but it is unclear whether LE was examined (Classen-Linke et al 2004).…”

Section: Lif In the Human Uterusmentioning

confidence: 99%

“…In cultured endometrial epithelial cells, TNF-a stimulates LIF, along with IL-6, secretion in a nerve factor-kB-dependent manner that also requires a functional proteosome compartment (Laird et al 2000). IL-1b, transforming growth factor-b (TGF-b) and TNF-a have also been shown to stimulate LIF production by first trimester human decidual cell-enriched cultures (Sawai et al 1997). However, these observations may not necessarily indicate the signalling pathways involved during early stages in implantation.…”

Section: Regulation Of Lif Expression In the Humanmentioning

confidence: 99%

Leukaemia inhibitory factor in implantation and uterine biology

Kimber¹

2005

Reproduction

148

110

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Leukaemia inhibitory factor (LIF) is one of the most important cytokines in the reproductive tract. Without expression of LIF in the uterus, implantation of a blastocyst cannot begin. Yet, 13 years after publication of the phenotype of the LIF knockout mouse we are only just beginning to understand how LIF functions in the uterus. This review addresses our knowledge of the role of LIF in regulating implantation through its influence on the luminal epithelium and stromal decidualization, but also its influence on reproductive tract cells such as leukocytes and glandular epithelium, during the pre-implantation phase of pregnancy.Reproduction (

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“…During pregnancy, LIF and LIF-R have been detected in the decidua and chorionic villi of first-trimester and term placenta in humans (Kojima et al, 1994;Kojima et al, 1995;Sawai et al, 1995;Sawai et al, 1997;Sharkey et al, 1999). LIF-R mRNA and immunoreactivity localizes in both villous and extravillous trophoblast throughout pregnancy, and in endothelial cells of the fetal villi (Sharkey et al, 1999).…”

Section: Uterine Decidual Cells: Interaction With Trophoblast During mentioning

confidence: 99%

Local regulation of implantation at the human fetal-maternal interface

et al. 2010

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Embryo implantation and formation of a functional placenta are complex processes that require a plethora of regulatory molecules. In recent years, many of these mediators have been identified, often from studies in experimental animals. Furthermore, their expression patterns at the embryo-maternal interface in women have been characterized and provide clues to their potential actions. What has been missing in most cases is any experimental demonstration of their function. Proteases, cytokines and chemokines are among the molecules identified at the embryo-maternal interface. Functional studies of the protease, proprotein convertase (PC)6, the gp130 cytokines, leukemia inhibitory factor (LIF) and interleukin (IL)11 and the chemokines, CX3CL1 and CCL14 demonstrate potential actions within the uterine cavity. These actions include: enhancing blastocyst development, modifying adhesive properties of the blastocyst and the uterine epithelial surface, and providing chemotactic guidance to the blastocyst. As implantation proceeds, PC6 and IL-11 also act to drive decidualization. The products (proteases, chemokines and cytokines) produced by these decidual cells provide a unique environment. This is important for both directing and restraining trophoblast invasion and for leukocyte trafficking into the decidua until the placenta is fully established.

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Human Decidual Cell Biosynthesis of Leukemia Inhibitory Factor: Regulation by Decidual Cytokines and Steroid Hormones1

Cited by 67 publications

References 36 publications

Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus)

Leukemia inhibitory factor ligand-receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus)

Leukaemia inhibitory factor in implantation and uterine biology

Local regulation of implantation at the human fetal-maternal interface

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