Human immunoglobulin G levels of viruses and associated glioma risk

Sjöström, Sara; Hjalmars, Ulf; Juto, Per; Wadell, Göran; Hallmans, Göran; Tjønneland, Anne; Halkjær, Jytte; Manjer, Jonas; Almquist, Martin; Melin, Beatrice

doi:10.1007/s10552-011-9799-3

Cited by 32 publications

(43 citation statements)

References 41 publications

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“…IgG for varicella zoster was inversely Brought to you by | Oakland University Authenticated Download Date | 7/3/15 7:15 PM correlated with glioma and some studies reported multiple HCMV gene products in glial tumors when compared to normal tissue (5). VZV IgG levels were more common in glioma cases vs. controls in another study (OR=0.68, 95% CI= 0.41-1.13) (112).…”

Section: Allergies Atopic Conditions Infections Other Disease Medmentioning

confidence: 91%

Risk factors for gliomas. An extensive review

Florian¹,

Ungureanu²,

Berce³

2013

Romanian Neurosurgery

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Section: Allergies Atopic Conditions Infections Other Disease Medmentioning

confidence: 91%

Risk factors for gliomas. An extensive review

Florian¹,

Ungureanu²,

Berce³

2013

Romanian Neurosurgery

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“…Unconditional logistic regression models were used to calculate odds ratios and 95% confidence intervals (CI) for the associations between glioma status and regular oral antihistamine use, adjusting for potential confounders (which were chosen a priori ). History of chickenpox was included in our models as a potential confounder because a growing body of literature indicates that varicella-zoster exposure may be relevant to glioma risk [32–35] and may also potentially impact the risk for atopic conditions [36, 37]. The regression models were run both among the overall study population and stratified by self-reported allergy/asthma status, as antihistamines are sometimes taken regularly for indications other than allergic conditions (i.e., as sleep aids or antiemetics).…”

Section: Methodsmentioning

confidence: 99%

Antihistamine use and immunoglobulin E levels in glioma risk and prognosis

Amirian

Marquez-Do

Bondy

et al. 2013

Cancer Epidemiology

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Objective An inverse association between personal history of allergies/asthma and glioma risk has been fairly consistently reported in the epidemiologic literature. However, the role of regular antihistamine use remains controversial due to a small number of studies reporting contradictory findings. We evaluated the association between regular use of oral antihistamines and glioma risk, adjusting for a number of relevant factors (e.g., immunoglobulin E levels and history of chickenpox). Methods We used a subset of the Harris County Case-Control Study, which included 362 pathologically-confirmed glioma cases and 462 cancer-free controls, to evaluate this association using unconditional multivariable logistic regression. These models were run among the overall study population and stratified by allergy status. Cox regression was utilized to examine whether antihistamine use was associated with mortality among all cases and separately among high-grade cases. Results Antihistamine use was strongly associated with glioma risk among those with a positive allergy/asthma history (OR: 4.19, 95% CI: 2.06–8.51), but not among those with a negative history (OR: 1.59, 95% CI: 0.95–2.67). There were no significant associations between antihistamine use and survival among cases. Conclusion The current study implies that regular antihistamine use may increase glioma risk. However, several larger studies are necessary before definitive conclusions can be drawn.

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“…25 Subsequent serologic studies for four neurotropic herpesviruses, herpes simplex virus (HSV), cytomegalovirus (CMV), VZV and Epstein-Barr virus (EBV), showed that only VZV-specific immunoglobulin levels were significantly and inversely associated with glioma risk. 6-8 To obtain more detailed biological insights, the current study analyzed glioma patients’ serological responses against 10 different VZV proteins. Accordingly, antibodies to viral proteins showed strong inverse yet individually variable correlations with glioma risk, suggesting a connection of anti-VZV immunity to cancer development.…”

Section: Discussionmentioning

confidence: 99%

Interaction of allergy history and antibodies to specific varicella‐zoster virus proteins on glioma risk

Lee

Bracci

Zhou

et al. 2013

Intl Journal of Cancer

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Glioma is the most common cancer of the central nervous system but with few confirmed risk factors. Glioma has been inversely associated with chicken pox, shingles, and seroreactivity to varicella virus (VZV), as well as to allergies and allergy-associated IgE. The role of antibody reactivity against individual VZV antigens has not been assessed. Ten VZV-related proteins, selected for high immunogenicity or known function, were synthesized and used as targets for antibody measurements in the sera of 143 glioma cases and 131 healthy controls selected from the San Francisco Bay Area Adult Glioma Study. Glioma cases exhibited significantly reduced seroreactivity compared to controls for six antigens, including proteins IE63 (OR = 0.26, 95%CI:0.12-0.58, comparing lowest quartile to highest), and the VZV-unique protein ORF2p (OR = 0.44, 95%CI:0.21-0.96, lowest quartile to highest). When stratifying the study population into those with low and high self-reported allergy history, VZV protein seroreactivity was only associated inversely with glioma among individuals self-reporting more than two allergies. The data provide insight into both allergy and VZV effects on glioma: strong anti-VZV reactions in highly allergic individuals is associated with reduced occurrence of glioma. This result suggests a role for specificity in the anti-VZV immunity in brain tumor suppression for both individual VZV antigens and in the fine-tuning of the immune response by allergy. Anti-VZV reactions may also be a biomarker of effective CNS immunosurveillance due to the tropism of the virus.

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Human immunoglobulin G levels of viruses and associated glioma risk

Cited by 32 publications

References 41 publications

Risk factors for gliomas. An extensive review

Risk factors for gliomas. An extensive review

Antihistamine use and immunoglobulin E levels in glioma risk and prognosis

Interaction of allergy history and antibodies to specific varicella‐zoster virus proteins on glioma risk

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