2012
DOI: 10.1371/journal.pone.0046776
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Human Langerhans Cells Control Th Cells via Programmed Death-Ligand 1 in Response to Bacterial Stimuli and Nickel-Induced Contact Allergy

Abstract: Langerhans cells (LCs) are suspected to initiate inflammatory immune responses to contact allergens and pathogenic bacteria. In chronic infectious diseases, programmed death ligand (PD-L) 1 exhibits both inhibitory and costimulatory functions on T cell-mediated activation and tolerance. Here, we investigated the effects of contact allergens and bacterial stimuli on PD-L1 expression in LCs and the effects of altered PD-L1 expression on cytokine release of subsequently cocultured T cells. Monocyte-derived LCs (M… Show more

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Cited by 17 publications
(12 citation statements)
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“…Such a regulatory function was recently described by our group for coinhibitory molecules on primary LCs and their interaction with cognate receptors on cocultured CD4 + T cells [19]. In detail, it was a subpopulation of CCR6 + /CCR4 + cells that released increased amounts of IL-17 after anti-PD-L1 was administrated to nickel triggered LCs.…”
Section: Th17: New Players In Acdmentioning
confidence: 78%
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“…Such a regulatory function was recently described by our group for coinhibitory molecules on primary LCs and their interaction with cognate receptors on cocultured CD4 + T cells [19]. In detail, it was a subpopulation of CCR6 + /CCR4 + cells that released increased amounts of IL-17 after anti-PD-L1 was administrated to nickel triggered LCs.…”
Section: Th17: New Players In Acdmentioning
confidence: 78%
“…In contrast, APCs restrict, diminish, or shut off specific T-cell responses via negative signals, if members of the B7:CD28 family induce tolerance [11]. In ACD and hypersensitivity models, a crucial inhibitory function was reported for B7 molecules and their ligands CTL-A4 [12–14], ICOSL:ICOS [15, 16], and PD-L1/-L2:PD-1 [1719]. However, in response to a complete interaction of activating molecules, allergen-stimulated APCs release cytokines such as IL-12, IL-6, and IL-23 that could drive T-cell polarization.…”
Section: Contact Dermatitis: Inflammation Of the Skin By Complex Imentioning
confidence: 99%
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“…However, at present, it is not known whether Tregs prevent effector T-cell responses in tolerant patients. A recent report indicates that PD-L1 expressed on dendritic cells plays a critical role in allergic reactions to nickel by controlling the nature of the antigen-specific T-cell response (Hitzler et al, 2012). Thus, regulatory receptor ligand binding interactions between dendritic cells and naive T cells likely also play an important role in HLA-restricted drugspecific T-cell priming.…”
Section: J Additional Factors Involved In Susceptibility To Hla-assomentioning
confidence: 99%
“…Notably, human LC were found to display a poor capacity to internalize bacteria and to process and present HLA-II-restricted Ags [55,85]. In addition, LC have been shown to negatively regulate Th cell responses to contact allergens through PDL-1 [86]. At the same time, however, human LC constitutively express high amounts of CD1a and efficiently stimulate CD1a-restricted immune responses that in turn amplify Th17 immunity in vivo [57].…”
Section: Innate Immune Cell Determinants Of Cutaneous T Cell Responsesmentioning
confidence: 99%