Human leukocyte antigen-G (HLA-G) expression in cervical cancer lesions is associated with disease progression

Li, Xiang-Juan; Zhang, Xia; Lin, Aifen; Ruan, Yiwen; Yan, Wei‐Hua

doi:10.1016/j.humimm.2012.07.041

Cited by 60 publications

(57 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these studies, there is a high frequency of tumor cell-surface HLA-G expression with an absence in healthy tissue, and increased sHLA-G levels has been detected in various body fluids in a variety of cancers (14). Expression of HLA-G was found to be correlated with clinical parameters such as more advanced disease stage, tumor metastasis and/or with a worse prognosis in tumor patients, indicating that HLA-G could facilitate tumor immune escape, invasiveness and metastasis; thereby HLA-G expression was found to be associated with advanced clinical stage and disease progression and HLA-G expression was also documented as an unfavorable prognostic factor for many kinds of solid malignancies, including breast cancer (59)(60)(61)(62)(63)(64), colorectal cancer (65,66), cervical cancer (67,68), endometrial of allogeneic skin graft survival (52). In an immunocompetent HLA-G1 + M8…”

Section: Relevance Of Hla-g Expression In Cancersmentioning

confidence: 99%

Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy

Lin

Yan

2015

Mol Med

Self Cite

108

View full text Add to dashboard Cite

Aberrant induction of human leukocyte antigen-G (HLA-G) expression has been observed in various malignancies and is strongly associated with tumor immune escape, metastasis and poor prognosis. To date, great achievements have been made in understanding the underlying mechanisms of HLA-G involved in tumor progression. HLA-G could lead to tumor evasion by inhibition of immune cell cytolysis, differentiation and proliferation and inhibition of cytokine production, induction of immune cell apoptosis, generation of regulatory cells and expansion of myeloid-derived suppressive cells and by impairment of chemotaxis. Moreover, HLA-G could arm tumor cells with a higher invasive and metastatic potential with the upregulation of tumor-promoting factor expression such as matrix metalloproteinases (MMPs), indicating that ectopic HLA-G expression could render multiple effects during the progression of malignancies. In this review, we summarized the mechanisms of HLA-G involved in promoting tumor cell immune escaping, metastasis and disease progression. Special attention will be paid to its significance as an attractive therapeutic target in cancers.

show abstract

Section: Relevance Of Hla-g Expression In Cancersmentioning

confidence: 99%

Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy

Lin

Yan

2015

Mol Med

Self Cite

108

View full text Add to dashboard Cite

show abstract

“…However, it has been reported that HLA-G expression in cancer cells lead to escape from the host's immune system (20). As shown in Table 4, the published data on HLA-G expression in different types of cancers had conflicts as follows: the positive rate of 90.9% positivity in esophageal squamous cell carcinoma (21) and 62.8% in cervical cancer (22), 60% and 38.88% in (26) breast cancer (23,24) and different frequency of HLA-G expression in colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Human Leucocyte Antigen G (HLA-G) Expression in the Prognosis of Colorectal Cancer

Samadi

Nazemalhosseini‐Mojarad

Molaei

et al. 2017

Int J Cancer Manag

View full text Add to dashboard Cite

Objectives: Overexpression of human leukocyte antigen G (HLA-G) in several malignant tumors has been reported. The aim of our study was to investigate HLA-G expression in colorectal cancer tumors and determine HLA-G expression relation between clinicopathological characteristics and survival time.Methods: HLA-G expression was evaluated by immunohistochemistry (IHC) using anti-HLA-G antibody in 100 primary tumors of colorectal cancer with different stages. Results:Our results showed that 25% of the colorectal cancer tissues had positive HLA-G expression and 75% no stained with anti-HLA-G antibody. The HLA-G expression in advanced stages (III and IV) was more prevalent than those in earlier clinical stages (I and II) (P = 0.0001). Results showed that HLA-G expression can serve as an independent factor for overall survival (OS). In this study, patients with HLA-G expression had significantly shorter survival time than those with negative expressions (P = 0.023).Conclusions: HLA-G expression can serve as an independent factor for OS and its expression may be directly related to aggressive tumor behavior via escape from the host antitumor immune defense. Protein expression of HLA-G correlates with poor prognosis in colorectal cancer.

show abstract

“…Upregulation of HLA‐G in tumor cells may be induced by IFNγ in the antitumor elimination phase, by epigenetic alterations of tumor cells, by hypoxia or by immunosuppressive factors in the tumor environment such as IL‐10 . HLA‐G expression was previously shown to be associated with progression of cervical lesions and other types of cancer . In addition, lack of HLA‐G expression was an independent prognostic indicator of prolonged survival in patients with colorectal cancer .…”

Section: Discussionmentioning

confidence: 99%

Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV‐induced usual vulvar intraepithelial neoplasia and implications for immunotherapy

Esch

Tummers

Baartmans

et al. 2014

Intl Journal of Cancer

View full text Add to dashboard Cite

Immunotherapy of usual vulvar intraepithelial neoplasia (uVIN) is promising; however, many patients still fail to show clinical responses, which could be explained by an immune escape through alterations in human leukocyte antigen (HLA) expression. Therefore, we analyzed a cohort of patients with a primary (n 5 43) and subsequent recurrent uVIN lesion (n 5 20), vaccinetreated uVIN patients (n 5 12), patients with human papillomavirus (HPV)-induced vulvar carcinoma (n 5 21) and healthy controls (n 5 26) for the expression of classical HLA-class I/II and nonclassical HLA-E/-G and MHC class I chain-related molecule A (MICA). HLA-class I was downregulated in 70% of uVIN patients, including patients with a clinical response to immunotherapy. Downregulation of HLA-class I is probably reversible, as only 15% of the uVIN cases displayed loss of heterozygosity (LOH) and HLA-class I could be upregulated in uVIN keratinocyte cultures by interferon c. HLA-class I downregulation is more frequently associated with LOH in vulvar carcinomas (25-55.5%). HLA-class II was found to be focally expressed in 65% of uVIN patients. Of the nonclassical molecules, MICA was downregulated in 80% of uVIN whereas HLA-E and -G were expressed in a minority of cases. Their expression was more prominent in vulvar carcinoma. No differences were found between the alterations observed in paired primary and recurrent uVIN. Importantly, downregulation of HLA-B/C in primary uVIN lesions was associated with the development of recurrences and progression to cancer. We conclude that downregulation of HLA is frequently observed in premalignant HPV-induced lesions, including clinical responders to immunotherapy, and is associated with worse clinical outcome. However, in the majority of cases downregulation may still be reversible.Usual vulvar intraepithelial neoplasia (uVIN) is a chronic premalignant skin condition with an increasing incidence mainly in young women, which is caused by a persistent high-risk human papillomavirus (HPV) infection in more than 90% of cases.1,2 uVIN causes complaints of severe and long-lasting pruritis, pain and sexual dysfunction and has a malignant potential of 3-4% in treated and of 9% in untreated patients.1,3 Because conventional treatments for uVIN are characterized by high recurrence rates of 20-40% and psychosexual problems, there is a need for alternative therapies. [4][5][6] Failure of the immune system to induce a strong and effective immune response to HPV is known to cause

show abstract

Human leukocyte antigen-G (HLA-G) expression in cervical cancer lesions is associated with disease progression

Cited by 60 publications

References 30 publications

Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy

Human Leukocyte Antigen-G (HLA-G) Expression in Cancers: Roles in Immune Evasion, Metastasis and Target for Therapy

Clinical Value of Human Leucocyte Antigen G (HLA-G) Expression in the Prognosis of Colorectal Cancer

Alterations in classical and nonclassical HLA expression in recurrent and progressive HPV‐induced usual vulvar intraepithelial neoplasia and implications for immunotherapy

Contact Info

Product

Resources

About