Human leukocyte antigen (HLA-F) polymorphism is associated with chronic HBV infection

Laaribi, Ahmed Baligh; Hannachi, Naila; Yahia, Hamza Ben; Marzouk, Manal; Mehri, A.; Belhadj, M.; Yacoub, S.; Létaief, A.; Ouzari, Hadda‐Imene; Boudabous, Abdellatif; Boukadida, Jalel; Rizzo, Roberta; Zidi, Inès

doi:10.1007/s13205-017-1079-9

Cited by 12 publications

(18 citation statements)

References 31 publications

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“…Since the discovery of HLA-F (HLA-5.4) in 1990 by Geraghty and coworkers, only a small amount of evidence for its clinical relevance has been obtained (6, 16). For example, the genetic variants and protein expression of HLA-F have been observed to be associated with different types of diseases, such as cancer (17–19), infection (20, 21), reproduction, and autoimmune disorders (22–25). Elevated HLA-F expression has been found in cancer lesions and peripheral blood, which was associated with poor survival in cancer patients (19, 26).…”

Section: Introductionmentioning

confidence: 99%

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

Lin

Yan

2019

Front. Immunol.

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Human leukocyte antigens (HLAs) play various critical roles in both innate and adaptive immunity through processes such as presenting antigens to T cells and serving as ligands for receptors expressed on natural killer (NK) cells. Among the HLA class I family, the clinical significance and biological function of HLA-F have been the least investigated and have remained elusive for a long period of time. Previous studies have revealed that HLA-F expression might be involved in various physiological and pathological processes, such as pregnancy, viral infection, cancer, transplantation, and autoimmune diseases. However, recent data have shown that, akin to other HLA family members, HLA-F molecules can interact with both activating and inhibitory receptors on immune cells, such as NK cells, and can present a diverse panel of peptides. These important findings pave new avenues for investigations regarding the functions of HLA-F as an important immune regulatory molecule. In the present review, we summarize the studies on the role of HLA-F in immune modulation, with a special emphasis placed on the roles of HLA-F and KIR3DS1 interactions in viral infection.

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Section: Introductionmentioning

confidence: 99%

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

Lin

Yan

2019

Front. Immunol.

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“…HLA-F is located at the terminal end of chromosome 6, is one of the non-classical HLA class Ib molecules, and is considered as a tolerogenic molecule [16]. HLA-F is a ligand for KIR receptors in natural killer cells (NK cells) and CD8 + T cells.…”

Section: Introductionmentioning

confidence: 99%

Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples

Feng

Liang

Wang

et al. 2019

J Neuroinflammation

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BackgroundHuman gliomas are highly fatal tumors with a significant feature of immune suppression. The association of the immune system in gliomas is gradually revealed, and immunotherapy is expected to improve the survival of glioma patients. In-depth understanding of the immune microenvironment of gliomas and their associated immunotherapy was increased exponentially in recent years. Gliomas provide clinical targets for immunotherapy during the search of key regulators of immune response. Our study focused on the human leukocyte antigen (HLA) system that is responsible for regulating the immune system, and discovered the relationship between HLA-F expression and clinical prognosis in gliomas.MethodsA total of 593 patients with gliomas were included in our research. Of these, 325 patients were from the Chinese Glioma Genome Atlas (CGGA) and 268 were from the GSE 16011 set. Kaplan-Meier (KM) analysis was performed to explore the prognostic value of HLA-F. t test analysis was used to find the distribution difference in various groups. R language packages are used for other statistical computations and figure drawing.ResultsHLA-F was negatively correlated with overall survival (OS) in all grades of glioma and glioblastoma (GBM). Moreover, HLA-F was enriched in GBM and isocitrate dehydrogenase 1 wild-type (IDH1 wt) group and considered HLA-F as a mesenchymal subtype marker. Pearson correlation test showed that HLA-F was correlated with other HLA-I molecules.ConclusionHLA-F expression was positively correlated with malignant phenotype and negatively correlated with OS, indicating that HLA-F could predict the immune state of gliomas and might be a clinical target of glioma immunotherapy.

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“… 6 – 9 , 36 , 37 In addition, this choice is in the wake of studies that seek to understand how genetic factors and cells of the innate immune system are involved in cases of virus infection. 38 – 40 In Burkina Faso, a significant proportion of patients with chronic hepatitis B (cHBV) acquired the infection early in life through mother-to-child transmission. 41 , 42 The average age of our study population was 34.75±11.57 years.…”

Section: Discussionmentioning

confidence: 99%

Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso

Sorgho

Martinson

Djigma

et al. 2018

Mediterr J Hematol Infect Dis

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Background/ObjectiveHepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC). The objective of this investigation was to assess the association between “Killer Cell Immunoglobulin-Like Receptor” (KIR) gene frequencies and chronic HBV infection.MethodsChronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed, and SSP-PCR was used to characterize the frequencies of KIR genes.ResultsThe study suggested that inhibitory genes KIR2DL2 (crude OR = 2.82; p < 0.001), KIR2DL3 (crude OR = 2.49; p < 0.001) and activator gene KIR2DS2 (crude OR = 3.95; p< 0.001) might be associated with chronic stages of HBV infection. Conversely the inhibitory genes KIR3DL1 (crude OR = 0.49; p = 0.0018) and KIR3DL2 (crude OR = 0.41; p = 0.005), the activator gene KIR2DS1 (crude OR = 0.48; p = 0.014) and the pseudo gene KIR2DP1 (crude OR = 0.49; p = 0.008) could be associated with immunity against HBV infection. Chronic HBV patients who are carriers for the KIR3DL3 gene (crude OR = 8; p = 0.048) were positive for HBeAg and patients who carried the KIR3DL2 gene (crude OR = 3.21; p = 0.012) had a high HBV viral load compared to the rest of the study population.ConclusionOur data showed evidence of a correlation between the risk of developing chronic HBV infection and certain KIR gene frequencies and also show that KIR3DL1, KIR3DL2, KIR2DS1 might confer a protective status against chronic HBV infection.

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Human leukocyte antigen (HLA-F) polymorphism is associated with chronic HBV infection

Cited by 12 publications

References 31 publications

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

The Emerging Roles of Human Leukocyte Antigen-F in Immune Modulation and Viral Infection

Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples

Insights into the interplay between KIR gene frequencies and chronic HBV infection in Burkina Faso

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