Human Metapneumovirus in Children Tested at a Tertiary‐Care Hospital

McAdam, Alexander J.; Hasenbein, Meredith E.; Feldman, Henry A.; Cole, Sarah; Offermann, Jeffrey T.; Riley, Ann Marie; Lieu, Tracy A.

doi:10.1086/421120

Cited by 92 publications

(83 citation statements)

References 35 publications

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“…These findings are consistent with other studies, which have demonstrated a higher prevalence of hMPV infections in spring and late winter [12,16,21,27,28]. Interestingly, in the French [8], Dutch [11] and Norwegian studies [19], hMPV was found at a higher rate in December and January.…”

Section: Discussionsupporting

confidence: 92%

“…However, higher rates have also been reported [19,20]. hMPV infections are associated with hospitalization of children [15,16,[21][22][23]. hMPV has also been associated with URTIs and may be responsible for 5-15% of cases of URTIs in children [24].…”

mentioning

confidence: 99%

“…Since its initial description, hMPV has been identified as a leading cause of LRTIs in previously healthy infant and child outpatients [11]. The incidence of hMPV-associated LRTI in young children varies with geographical location and time of year, and can range from 5 to 15% [12][13][14][15][16][17][18]. However, higher rates have also been reported [19,20].…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Althani¹,

Azzam

Abboubaker

et al. 2010

Future Virol.

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Aim: The human metapneumovirus (hMPV) has been recently discovered as an etiological agent of acute respiratory infections in infants and children, with similar clinical symptoms to those caused by respiratory syncytial virus. The aim of this study was to determine the prevalence of hMPV and its potential role as a causative agent of respiratory tract infections in children in Qatar. Methods: In the present study, we examined 84 nasopharyngeal aspirates from children with respiratory tract infections, presenting at Al-Saad Pediatric Emergency Center in Doha, Qatar, as outpatients, for the presence of respiratory viruses. Results: A total of 56 out of 84 (66.7%) cases were positive for the presence of respiratory viruses. Out of the 56 positive cases 54 (96%) contained hMPV; whereas 12 out of 56 (21.4%) contained human parainfluenza virus. A total of 14 out of 56 of the positive patients were infected with more than one virus. hMPV was in samples infected with one or more respiratory tract infection viruses and was the most frequently isolated virus from infants less than 6 months of age. Conclusion: This is the first report demonstrating the prevalence of hMPV in children suffering from respiratory tract infections in Qatar. Detection of this virus may have significant clinical implications in this patient population in Qatar.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 99%

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The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Althani¹,

Azzam

Abboubaker

et al. 2010

Future Virol.

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“…Children and adults with comorbid conditions, such as those with congenital heart or lung diseases, cancer, or immunodeficiency, are at particular risk for severe respiratory disease from hMPV infection (28,48). Epidemiology studies have suggested that hMPV infection causes lower respiratory tract disease in 5 to 15% of otherwisehealthy infants and young children (6,16,22,27,28,47). Recurrent infection with hMPV also has been documented (14,50).…”

mentioning

confidence: 99%

An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats

Mok

Tollefson²,

Podsiad³

et al. 2008

J Virol

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Human metapneumovirus (hMPV) is a recently discovered paramyxovirus that causes upper and lower respiratory tract infections in infants, the elderly, and immunocompromised individuals worldwide. Here, we developed Venezuelan equine encephalitis virus replicon particles (VRPs) encoding hMPV fusion (F) or attachment (G) glycoproteins and evaluated the immunogenicity and protective efficacy of these vaccine candidates in mice and cotton rats. VRPs encoding hMPV F protein, when administered intranasally, induced F-specific virus-neutralizing antibodies in serum and immunoglobulin A (IgA) antibodies in secretions at the respiratory mucosa. Challenge virus replication was reduced significantly in both the upper and lower respiratory tracts following intranasal hMPV challenge in these animals. However, vaccination with hMPV G protein VRPs did not induce neutralizing antibodies or protect animals from hMPV challenge. Close examination of the histopathology of the lungs of VRP-MPV F-vaccinated animals following hMPV challenge revealed no enhancement of inflammation or mucus production. Aberrant cytokine gene expression was not detected in these animals. Together, these results represent an important first step toward the use of VRPs encoding hMPV F proteins as a prophylactic vaccine for hMPV.

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“…HMPV accounts for roughly 5 to 15% of respiratory disease in hospitalized young children, with children under 2 years of age being most at risk for serious HMPV infections (1,7,11,18,20,33). Clinical symptoms resemble those caused by human respiratory syncytial virus (HRSV) (15,31).…”

mentioning

confidence: 99%

Infection of Nonhuman Primates with Recombinant Human Metapneumovirus Lacking the SH, G, or M2-2 Protein Categorizes Each as a Nonessential Accessory Protein and Identifies Vaccine Candidates

Biacchesi

Pham

Skiadopoulos

et al. 2005

J Virol

149

174

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Recombinant human metapneumovirus (HMPV) in which the SH, G, or M2 gene or open reading frame was deleted by reverse genetics was evaluated for replication and vaccine efficacy following topical administration to the respiratory tract of African green monkeys, a permissive primate host. Replication of the ⌬SH virus was only marginally less efficient than that of wild-type HMPV, whereas the ⌬G and ⌬M2-2 viruses were reduced sixfold and 160-fold in the upper respiratory tract and 3,200-fold and 4,000-fold in the lower respiratory tract, respectively. Even with the highly attenuated mutants, there was unequivocal HMPV replication at each anatomical site in each animal. Thus, none of these three proteins is essential for HMPV replication in a primate host, although G and M2-2 increased the efficiency of replication. Each gene-deletion virus was highly immunogenic and protective against wild-type HMPV challenge. The ⌬G and ⌬M2-2 viruses are promising vaccine candidates that are based on independent mechanisms of attenuation and are appropriate for clinical evaluation.

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Human Metapneumovirus in Children Tested at a Tertiary‐Care Hospital

Abstract: hMPV is common among young children with apparent respiratory infections, suggesting that it is a significant cause of symptomatic respiratory infections.

Cited by 92 publications

References 35 publications

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

An Alphavirus Replicon-Based Human Metapneumovirus Vaccine Is Immunogenic and Protective in Mice and Cotton Rats

Infection of Nonhuman Primates with Recombinant Human Metapneumovirus Lacking the SH, G, or M2-2 Protein Categorizes Each as a Nonessential Accessory Protein and Identifies Vaccine Candidates

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