Human multidrug-resistant Mycobacterium bovis infection in Mexico

Vazquez-Chacon, Carlos A.; Martínez-Guarneros, Armando; Couvin, David; González-y-Merchand, Jorge A.; Rivera-Gutierrez, Sandra; Escobar‐Gutiérrez, Alejandro; López, Juan J. De-la-Cruz; Gomez-Bustamante, Adriana; Gonzalez-Macal, Gabriela A.; Rossi, Liana Chesini; Muñíz-Salazar, Raquel; Rastogi, Nalin; Vaughan, Gilberto

doi:10.1016/j.tube.2015.07.010

Cited by 19 publications

(10 citation statements)

References 28 publications

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“…All three spoligotypes described above (SB0145, SB1040, and SB0971) have been reported previously in Baja California (Milián-Suazo et al, 2012). Previously, spoligotypes SB0327, SB0140, and SB0986 have been found in cattle from the municipality of Mexicali, but they have also been described in other regions of Mexico (Zumárraga et al, 2013;Rodwell et al, 2010;Milián-Suazo et al, 2012;Vazquez-Chacon et al, 2015). Spoligotypes SB1345, SB1758, and SB1760 have been reported previously in humans in San Diego County, USA (Rodwell et al, 2010), matching cattle from Tijuana and Ensenada in this study.…”

Section: Discussionsupporting

confidence: 80%

Whole genome sequencing of Mycobacterium bovis to obtain molecular fingerprints in human and cattle isolates from Baja California, Mexico

Sandoval-Azuara

Muñíz-Salazar

Perea-Jacobo

et al. 2017

International Journal of Infectious Diseases

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All isolates from humans had spoligotype patterns that matched those observed in the cattle isolates, and all human isolates shared common ancestors with cattle in Baja California based on SNP analysis. This suggests that most human tuberculosis caused by M. bovis in Baja California is derived from M. bovis circulating in Baja California cattle. These results reinforce the importance of bovine tuberculosis surveillance and control in this region.

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Section: Discussionsupporting

confidence: 80%

Whole genome sequencing of Mycobacterium bovis to obtain molecular fingerprints in human and cattle isolates from Baja California, Mexico

Sandoval-Azuara

Muñíz-Salazar

Perea-Jacobo

et al. 2017

International Journal of Infectious Diseases

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“…This is particularly concerning given that the emergence of multidrug-resistant strains of M . bovis has been reported [ 56 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique

et al. 2018

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Bovine tuberculosis is a zoonotic disease with largely unknown impact in Africa, with risk factors such as HIV and direct contact with animals or consumption of Mycobacterium bovis infected animal products. In order to understand and quantify this risk and design intervention strategies, good epidemiological studies are needed. Such studies can include molecular typing of M. bovis isolates. The aim of this study was to apply these tools to provide novel information concerning the distribution of bovine tuberculosis in cattle in Mozambique and thereby provide relevant information to guide policy development and strategies to contain the disease in livestock, and reduce the risk associated with transmission to humans. A collection of 178 M. bovis isolates was obtained from cattle in Mozambique. Using spoligotyping and regions of difference analysis, we classified the isolates into clonal complexes, thus reporting the first characterisation of M. bovis strains in this region. Data from MIRU-VNTR typing was used to compare isolates from a number of African countries, revealing a deeply geographically structured diversity of M. bovis. Eastern Africa appears to show high diversity, suggesting deep evolution in that region. The diversity of M. bovis in Africa does not seem to be a function of recent importation of animals, but is probably maintained within each particular region by constant reinfection from reservoir animals. Understanding the transmission routes of M. bovis in Mozambique and elsewhere is essential in order to focus public health and veterinary resources to contain bovine tuberculosis.

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“…In addition, there is a growing association of M . bovis related TB cases with treatment failure due to intrinsic resistance to some commonly used anti-tuberculosis drugs [11].…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology and whole genome sequencing analysis of clinical Mycobacterium bovis from Ghana

et al. 2019

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Background Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a re-emerging problem in both livestock and humans. The association of some M . bovis strains with hyper-virulence, MDR-TB and disseminated disease makes it imperative to understand the biology of the pathogen. Methods Mycobacterium bovis (15) among 1755 M . tuberculosis complex (MTBC) isolated between 2012 and 2014 were characterized and analyzed for associated patient demography and other risk factors. Five of the M . bovis isolates were whole-genome sequenced and comparatively analyzed against a global collection of published M . bovis genomes. Results Mycobacterium bovis was isolated from 3/560(0.5%) females and 12/1195(1.0%) males with pulmonary TB. The average age of M . bovis infected cases was 46.8 years (7-72years). TB patients from the Northern region of Ghana (1.9%;4/212) had a higher rate of infection with M . bovis (OR = 2.7,p = 0.0968) compared to those from the Greater Accra region (0.7%;11/1543). Among TB patients with available HIV status, the odds of isolating M . bovis from HIV patients (2/119) was 3.3 higher relative to non-HIV patients (4/774). Direct contact with livestock or their unpasteurized products was significantly associated with bTB (p<0.0001, OR = 124.4,95% CI = 30.1–508.3). Two (13.3%) of the M . bovis isolates were INH resistant due to the S315T mutation in katG whereas one (6.7%) was RIF resistant with Q432P and I1491S mutations in rpoB . M . bovis from Ghana resolved as mono-phyletic branch among mostly M . bovis from Africa irrespective of the host and were closest to the root of the global M . bovis phylogeny. M . bovis -specific amino acid mutations were detected among MTBC core genes such as mce1A , mmpL1 , pks6 , phoT , pstB , glgP and Rv2955c . Additional mutations P6T in chaA , G187E in mgtC , T35A in Rv1979c , S387A in narK1 , L400F in fas and A563T in eccA1 were ...

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Human multidrug-resistant Mycobacterium bovis infection in Mexico

Cited by 19 publications

References 28 publications

Whole genome sequencing of Mycobacterium bovis to obtain molecular fingerprints in human and cattle isolates from Baja California, Mexico

Whole genome sequencing of Mycobacterium bovis to obtain molecular fingerprints in human and cattle isolates from Baja California, Mexico

Genetic diversity and potential routes of transmission of Mycobacterium bovis in Mozambique

Molecular epidemiology and whole genome sequencing analysis of clinical Mycobacterium bovis from Ghana

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