Human papilloma virus 16/18: Fabricator of trouble in oral squamous cell carcinoma

Zil-e-Rubab,; Baig, Saeeda; Zaman, Uzma; Lucky, Mohammad Haris

doi:10.1016/j.ijid.2018.02.003

Cited by 18 publications

(6 citation statements)

References 27 publications

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“…The best ways to prevent OSCC are abstinence from smoking, alcohol, and chewable tobacco products. Another risk factor that is attributable to OSCC is HPV infection [3]. In Pakistan, OSCC is the most common malignancy reported in males with twice the incidence as compared to females [1].…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of OX40 in Early and Late-Stage Oral Squamous Cell Carcinoma

Sani¹,

Rubab²,

Usman³

et al. 2021

Cureus

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BackgroundThe tumor necrosis factor receptor superfamily, member 4 (OX40) and its ligand (OX40L) are members of the tumor necrosis factor superfamily and play roles as costimulatory immunomodulators to combat infectious diseases as well as cancers. Presently, many therapeutic agents focused on OX40 and OX40L are in trials for antitumor efficacy. In Pakistan, oral squamous cell carcinoma (OSCC) is the second most prevalent cancer with a mortality of 50% despite the availability of various therapeutic modalities. Data regarding serum levels of OX40 in patients with OSCC is lacking. Therefore, the study aimed to assess the OX40 levels in serum and their association with the clinicopathological features of the tumor. MethodologyA cross-sectional study was conducted and serum samples of 78 biopsy-confirmed OSCC patients were collected prior to any treatment along with 10 healthy persons after informed consent. Serum levels of OX40 were measured via sandwich enzyme-linked immunosorbent assay (ELISA). ResultsThe mean serum levels of OX40 were 1.65 ± 0.64 ng/ml and 2.39 ± 0.58 ng/ml in early and late-stage disease patients of OSCC, respectively (p =<0.005). However, based on gender and tumor site, male gender and buccal mucosa tumors in late-stage OSCC patients showed higher mean levels of OX40, 2.42± 0.58 ng/ml and 2.41 ± 0.58 ng/ml (p =<0.05), respectively. Patients with well-differentiated tumors demonstrated mean serum levels of 2.28 ng/ml, and in moderately differentiated tumors, the mean levels were 2.19 ng/ml (p =0.47). ConclusionsA high OX40 level is associated with advanced-stage disease and a poor prognosis, possibly reflecting the immune-exhausted status against OSCC.

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Section: Introductionmentioning

confidence: 99%

Serum Levels of OX40 in Early and Late-Stage Oral Squamous Cell Carcinoma

Sani¹,

Rubab²,

Usman³

et al. 2021

Cureus

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“…In contrast, previous study reported significant association between HPV-16 and chewed tobacco users. 21 The plausible reasons for the difference in findings could be related to sample size (100 oral squamous cell carcinomas compared to 50 HNSCC cases in the current study). Furthermore, we couldn't find statistically significant association between HPV-16 and age and gender which is in accordance with previous studies, however, others reported significant association of male predominance in HPV-associated HNSCC.…”

Section: Discussionmentioning

confidence: 74%

Frequency of HPV-16 in Saliva and Blood in Head and Neck Squamous Cell Carcinoma in Pakistani Population

Saher¹,

Syed²,

Iqbal³

et al. 2020

J Pak Dent Assoc

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OBJECTIVE: Pakistan is geographically located in the region where prevalence of head and neck squamous cell carcinoma (HNSCC) is high. Human papilloma virus (HPV) subtype-16 plays significant role in heterogeneity of HNSCC. The objective of this study was to evaluate the frequency of HPV-16 in both blood and saliva in HNSCC in our population and its association with clinicopathological features. METHODOLOGY: A total of 200 samples comprising 100 blood and 100 saliva samples were collected. Hundred samples (saliva; n=50, blood; n=50) were collected from histopathologically confirmed head and neck squamous cell carcinoma patients and 100 samples (saliva; n=50 saliva, blood; n=50) were collected from healthy individuals without a history of cancer as controls. HPV-16 was detected using conventional polymerase chain reaction and gel-electrophoresis. The frequency and distribution of clinicopathological variables were calculated in percentages. Chi-square test was used to analyze the association of HPV-16 positivity with clinicopathological variables. RESULTS: Of 100 samples from HNSCC patients, 11 (11%) samples were positive for HPV-16. Of 11 HPV-16 positive samples, 8 (16%) were detected in saliva (n=50) and 3 (6%) were detected in plasma (n=50). Of 100 samples from control group, both blood and saliva samples were negative for HPV-16. No statistically significant association was found between HPV-16 in saliva and blood and clinicopathological characteristics (P > 0.05). CONCLUSION: Within the limit of current study, HPV-16 has a low-frequency in saliva and blood in HNSCC in our population. Further studies on HNSCC with large sample and HPV-subtypes are suggested. KEYWORD: Blood; human papilloma virus; saliva; squamous cell carcinoma. HOW TO CITE: Saher S, Syed SA, Iqbal A, Syed FA, Amin F, Sultan A, Anees M. Frequency of HPV-16 in saliva and blood in head and neck squamous cell carcinoma in Pakistani population. J Pak Dent Assoc 2020;29(4):228-234.

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“…The HPV genotypes detected in head and neck squamous cell carcinoma (HNSCC) might differ from those in cervical cancers. HPV16 remains the most prevalent detected type (1.6–60.7%), followed by HPV31 (1.6–79.2%), HPV18 (0.7–15.1%), HPV56 (0.5–15.1%), HPV52 (2%), HPV33 (1.2%), and HPV35 (0.5%) [ 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 ]. Intriguingly, HPV31 (79.2%), HPV45 (87.4%), and HPV68 (49.1%) have been reported to have particularly high rates in Singapore.…”

Section: Hpv Genotype Distribution In East Southeast and South Asiamentioning

confidence: 99%

“…For HNSCC samples with a single HPV infection, most of the samples have been found to be positive for HPV16. Other detected hrHPV types include HPV31, 18, 56, 52, 33, and 35 [ 84 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 ]. Additionally, samples detected with HPV16/18 co-infection and multiple HPV genotypes were also reported [ 110 ].…”

Section: Hpv Genotype Distribution In East Southeast and South Asiamentioning

confidence: 99%

Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia

Xia

Long

et al. 2021

Cancers

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Human papillomavirus (HPV) infection remains one of the most prominent cancer-causing DNA viruses, contributing to approximately 5% of human cancers. While association between HPV and cervical cancers has been well-established, evidence on the attribution of head and neck cancers (HNC) to HPV have been increasing in recent years. Among the cancer-causing HPV genotypes, HPV16 and 18 remain the major contributors to cancers across the globe. Nonetheless, the distribution of HPV genotypes in ethnically, geographically, and socio-economically diverse East, Southeast, and South Asia may differ from other parts of the world. In this review, we garner and provide updated insight into various aspects of HPV reported in recent years (2015–2021) in these regions. We included: (i) the HPV genotypes detected in normal cancers of the uterine cervix and head and neck, as well as the distribution of the HPV genotypes by geography and age groups; (ii) the laboratory diagnostic methods and treatment regimens used within these regions; and (iii) the oncogenic properties of HPV prototypes and their variants contributing to carcinogenesis. More importantly, we also unveil the similarities and discrepancies between these aspects, the areas lacking study, and the challenges faced in HPV studies.

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Human papilloma virus 16/18: Fabricator of trouble in oral squamous cell carcinoma

Abstract: The exposure to high risk strains of Human papilloma virus (16/18) in combination can be fabricotor of trouble (p<0.001, Adjusted odds ratio; 21.42) in OSCC.

Cited by 18 publications

References 27 publications

Serum Levels of OX40 in Early and Late-Stage Oral Squamous Cell Carcinoma

Serum Levels of OX40 in Early and Late-Stage Oral Squamous Cell Carcinoma

Frequency of HPV-16 in Saliva and Blood in Head and Neck Squamous Cell Carcinoma in Pakistani Population

Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia

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