Human papillomavirus: An unlikely etiologic factor in sinonasal inverted papilloma

Mohajeri, Sepideh; Lai, Chi; Purgina, Bibianna; Almutairi, Dakheelallah; Baghai, Tabassom; Dimitroulakos, Jim; Kilty, Shaun

doi:10.1002/lary.27207

Cited by 31 publications

(30 citation statements)

References 26 publications

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“…The aetiological factors contributing to the formation of SIP and SOP are still unknown. Previous studies have demonstrated that the human papilloma virus (HPV) detection rate in SIP is quite variable, and that the role of HPV is ambiguous . SOP was reported to harbour no high‐risk HPV or low‐risk HPV .…”

Section: Discussionmentioning

confidence: 99%

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EGFR and KRAS mutations in Chinese patients with sinonasal inverted papilloma and oncocytic papilloma

Wang¹,

Li²,

Hu³

et al. 2019

Histopathology

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Aims Sinonasal inverted papilloma (SIP) and sinonasal oncocytic papilloma (SOP) are uncommon, benign epithelial neoplasms located in the sinonasal region, that have the potential for malignant transformation. A recent study reported that EGFR and KRAS mutations occurred in the majority of Western patients with SIP and SOP, respectively. The aims of this study were to investigate the prevalence of KRAS and EGFR mutations in Chinese SIP and SOP patients, and to study the association between molecular alterations and their clinical features. Methods and results We retrospectively collected 80 sinonasal papilloma specimens, including 44 cases with SIP, 33 cases with SOP, and three cases with mixed sinonasal papilloma, which harboured elements of both inverted and oncocytic types. Formalin‐fixed paraffin‐embedded tissues were used to extract genomic DNA, and EGFR and KRAS mutations were evaluated with direct Sanger sequencing. Thirty‐five (78%) SIP patients harboured EGFR mutations, and all mutations were exon 20 insertions, whereas no KRAS mutations were detected. In contrast, KRAS mutations were detected in 82% of SOP patients, but no EGFR mutations were detected. Among the three mixed‐type cases, two harboured both EGFR exon 20 insertions and KRAS mutations. Another case harboured a KRAS mutation, but no EGFR mutation was detected. Conclusion SIP and SOP are two clinical entities with different genetic mutational patterns of EGFR and KRAS. Mixed types with elements of both SIP and SOP may harbour both EGFR and KRAS mutations.

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Section: Discussionmentioning

confidence: 99%

“…Previous studies have demonstrated that the human papilloma virus (HPV) detection rate in SIP is quite variable, and that the role of HPV is ambiguous. 14,15 SOP was reported to harbour no high-risk HPV or low-risk HPV. 16 Recently, knowledge on the genetic alterations involved in SIP and SOP has increased.…”

Section: Discussionmentioning

confidence: 99%

EGFR and KRAS mutations in Chinese patients with sinonasal inverted papilloma and oncocytic papilloma

Wang¹,

Li²,

Hu³

et al. 2019

Histopathology

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“…reported that sinonasal IP progression to SCC was significantly associated with the presence of human papillomavirus (HPV) infection (14,15). However, Mohajeri et al compared HPV positivity among sinonasal IP samples and those from patients with SCC by immunohistochemistry and found that HPV was not supported as an etiological driver of IP development or progression to SCC (16). Thus, further research is required to confirm the association between HPV infection and SCC with IP.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma associated with inverted papilloma: Recurrence and prognostic factors

Zhang

et al. 2019

Oncol Lett

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The purpose of the present study was to review the recurrence and prognostic factors of squamous cell carcinoma (SCC) associated with inverted papilloma (IP). A retrospective chart review was conducted on 21 patients with SCC associated with IP, in the nasal cavity and paranasal sinuses, between March 2007 to March 2017. All patients underwent surgical treatment: Surgery prior to or following adjuvant therapy was performed in 17 patients (81.0%). During a mean follow-up time of 47.4 months (range, 3-123 months), 9 patients (42.9%) experienced local recurrence, and the risk factors of T4 stage and invasive orbital cavity had a significant influence on recurrence. The 1-, 3-, and 5-year overall survival rates were 90.5, 75.4 and 68.5%, and the 1-, 3-, and 5-year disease-specific survival (DSS) rates were 90.5, 80.4 and 80.4%, respectively. The prognosis of patients with stage T4 was not satisfactory compared with those with stage T3 or less, and a positive surgical margin was also significantly associated with poor survival. Overall, SCC associated with IP has a favorable DSS, early diagnosis and complete resection of lesions is required for a good prognosis. Furthermore, aggressive surgical approaches combined with postoperative adjuvant therapy seem to be effective in tumors at stage T4.

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“…Despite absence of HPV in our tonsillar specimens, p16 was present in the epithelium in all cases and in the lymphoid tissue in 92.5% of cases. However, intensity and number of positive cells were generally low when comparing to inverted sinonasal papilloma and oropharyngeal cancer . These low numbers of p16 seen probably resemble normal p16 expression in a regulated cell cycle, where p16 functions according to design.…”

Section: Discussionmentioning

confidence: 98%

Mapping of human papilloma virus, p16, and epstein‐barr virus in non‐malignant tonsillar disease

Holm

Schindele

Allard

et al. 2019

Laryngoscope Investig Oto

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Objectives Due to their location in the entrance of the aero‐digestive tract, tonsils are steadily exposed to viruses. Human papilloma virus (HPV) and Epstein‐Barr virus (EBV) are two potentially oncogenic viruses that tonsils encounter. The incidence of HPV positive tonsillar cancer is on the rise and it is unknown when infection with HPV occurs. Aim To investigate if tonsils are infected with HPV and EBV, to study the co‐expression of HPV and its surrogate marker p16, and to evaluate the number of EBV positive cells in benign tonsillar disease. Materials and Methods Tonsils from 40 patients in a university hospital were removed due to hypertrophy, chronic or recurrent infection. These were analyzed for presence of HPV, its surrogate marker p16, and EBV. HPV was studied using PapilloCheck (a PCR method), while p16 was identified in epithelial and lymphoid tissue with immunohistochemistry and EBV using EBER‐ISH (Epstein‐Barr encoding region–in situ hybridization). Results HPV was not detected, and p16 was present at low numbers in all epithelial samples as well as in 92.5% of the lymphoid tonsillar samples. At least one EBER‐positive cell was seen in 65% of cases. Larger numbers of EBER‐expressing cells were only seen in two cases. Conclusion These findings demonstrate that EBV and HPV infect tonsils independently, but further studies are warranted to confirm their infectious relationship. Level of Evidence Cross‐sectional study

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Human papillomavirus: An unlikely etiologic factor in sinonasal inverted papilloma

Abstract: NA Laryngoscope, 2443-2447, 2018.

Cited by 31 publications

References 26 publications

EGFR and KRAS mutations in Chinese patients with sinonasal inverted papilloma and oncocytic papilloma

EGFR and KRAS mutations in Chinese patients with sinonasal inverted papilloma and oncocytic papilloma

Squamous cell carcinoma associated with inverted papilloma: Recurrence and prognostic factors

Mapping of human papilloma virus, p16, and epstein‐barr virus in non‐malignant tonsillar disease

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