Human papillomavirus subtypes in oral lesions compared to healthy oral mucosa

Kristoffersen, Anne Karin; Enersen, Morten; Kverndokk, E.; Sunde, Pia Titterud; Landin, Maria A.; Solheim, Tore; Olsen, Ingar; Grinde, Bjørn

doi:10.1016/j.jcv.2011.12.023

Cited by 20 publications

(21 citation statements)

References 23 publications

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“…Our data corroborate those of Cianfriglia et al [6] and Kristoffersen et al [24], findings in a similar manner showing that there was no statistical difference between the groups studied, however, the absolute numbers of the rate of infection by HPV in the groups with leukoplakia were higher than those found in the control group. The authors of the present study recommend follow-up of the HPV-positive lesions, because the overall prevalence of HPV in patients with oral leukoplakia was higher in comparison with those with normal oral mucosa, therefore one must not exclude the possibility that HPV may play an important role in the development of oral leukoplakia.…”

Section: Resultssupporting

confidence: 93%

“…In this study, no statistical difference was found between the presence of HPV and the variables (sex, age, anatomic location of the lesion, tobacco and alcohol consumption, presence/ absence of dysplasia), data similar to those of other studies, in which there was no statistical difference for these variables and the presence of HPV in oral leukoplakias [1,19,24,29]. In the group of patients with oral leukoplakia the authors believed that age did not interfere in the status of HPV, differently from the group of patients with SCC of the head and neck, in whom a higher incidence of infection by HPV was reported in young patients, mainly due to sexual habits [19,30].…”

Section: Resultssupporting

confidence: 91%

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Plasma HPV DNA is detectable in oral leukoplakia patients

Ferreira

Biasoli

Bernabé

et al. 2017

Pathology - Research and Practice

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 91%

Plasma HPV DNA is detectable in oral leukoplakia patients

Ferreira

Biasoli

Bernabé

et al. 2017

Pathology - Research and Practice

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“…Some of the relatively larger studies from India [30], Scandinavia [60], and China [96] demonstrate significantly greater oral HPV carrier rates as compared to the other studies, suggesting that real geographic differences may be present. The WP of intraoral HPV detection is significantly lower than the rate of HPV detection in oral carcinomas (6.9 vs. 20.2 %, respectively, p = 0.0002).…”

Section: Resultsmentioning

confidence: 98%

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

228

218

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Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on ''treatment deintensification'' for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.

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“…Baixas prevalências foram encontradas por Ammatuna et al 7 (3,3%) e Migaldi et al 8 na Itália (1,2%). Altas prevalências foram observadas por Zhang et al 9 na China (55%) e Kristoffersen et al 10 na Noruega (56%).…”

Section: Discussionunclassified

“…Kristoffersen et al 10 verificaram presença de HPV 6, 11 e 16. HPV 6 e 11 foram encontrados em duas amostras concomitantemente; HPV 6, em 11 amostras; HPV 11, em 7 amostras; e HPV 16, em uma.…”

Section: Discussionunclassified