Human Pseudoterranovosis, an Emerging Infection in Chile

Torres, Patricio; Jercic, María Isabel; Weitz, Juan Carlos; Dobrew, E. K.; Mercado, Rubén

doi:10.1645/ge-946r.1

Cited by 51 publications

(47 citation statements)

References 12 publications

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“…4), differentiation between Anisakis and Pseudoterranova infection may also be possible. Although human Anisakis infections are much more prevalent, pseudoterranovosis is currently arising as an emerging infection in some countries where consumption of raw fish in different dishes such as sushi, sashimi and ceviche is becoming popular [28,29]. In contrast to the failure of the Anisakis dead larvae to induce a good antibody response against the polypeptide t-Ani s 7 in rats, dead larvae were able to induce a strong IgG1 response and slight IgE, IgA, IgG2b and IgG2c responses when nAni s 7 was used as target antigen in capture ELISA.…”

Section: Igg1mentioning

confidence: 99%

TheAnisakis simplexAni s 7 major allergen as an indicator of trueAnisakisinfections

Anadón

Romarís

Escalante

et al. 2009

Clinical and Experimental Immunology

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SummaryAni s 7 is currently the most important excretory/secretory (ES) Anisakis simplex allergen, as it is the only one recognized by 100% of infected patients. The allergenicity of this molecule is due mainly to the presence of a novel CX17-25CX9-22CX8CX6 tandem repeat motif not seen in any previously reported protein. In this study we used this allergen as a model to investigate how ES allergens are recognized during Anisakis infections, and the usefulness of a recombinant fragment of Ani s 7 allergen (t-Ani s 7) as a marker of true Anisakis infections. The possible antigenic relationship between native Ani s 7 (nAni s 7) from Anisakis and Pseudoterranova decipens antigens was also investigated. Our results demonstrate that nAni s 7 is secreted and recognized by the immune system of rats only when the larvae are alive (i.e. during the acute phase of infection), and that this molecule is not present in, or is antigenically different from, Pseudoterranova allergens. The t-Ani s 7 polypeptide is a useful target for differentiating immunoglobulin E antibodies induced by true Anisakis infections from those induced by other antigens that may crossreact with Anisakis allergens, including P. decipiens. The results also support the hypothesis that the Ani s 7 major allergen does not participate in maintaining the antigenic stimulus during chronic infections.

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Section: Igg1mentioning

confidence: 99%

TheAnisakis simplexAni s 7 major allergen as an indicator of trueAnisakisinfections

Anadón

Romarís

Escalante

et al. 2009

Clinical and Experimental Immunology

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“…Although now reported worldwide (Lee 1998, Koh et al 1999Yu et al, 2001;Arizono et al, 2011;Mattiucci et al, 2011;Torres et al, 2007) far fewer cases of nematode infection ascribed to Pseudoterranova spp. are reported in the literature compared with those attributed to Anisakis spp.…”

Section: Zoonotic Potentialmentioning

confidence: 99%

Scientific Opinion on assessment of epidemiological data in relation to the health risks resulting from the presence of parasites in wild caught fish from fishing grounds in the Baltic Sea

2011

EFS2

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For fishery products caught from fishing grounds in the Baltic Sea, four groups of viable parasites present possible health risks, Anisakis simplex (sensu stricto), Contracaecum osculatum (sensu stricto), Pseudoterranova decipiens (sensu stricto) and Diphyllobothrium spp. Since A. simplex and Pseudoterranova decipiens have been found in fishery products in International Council for the Exploration of the Sea (ICES) subdivisions 22, 23, 24, 25, 26, public health risks due to the presence of these parasites cannot be excluded in any fishery products caught from these areas. Migrating fish from areas where A. simplex, and to a lesser degree P. decipiens, occur may carry these parasites and reach the northern Baltic, therefore, public health risks due to parasites in all migrating fish (including salmon) in Baltic Sea cannot be excluded. C. osculatum occurs in fish throughout all areas of the Baltic Sea. However, at present it is not possible to assess the public health importance of viable C. osculatum larvae in fishery products. Diphyllobothrium spp. occurs in fish species in brackish waters of Baltic Sea. Hence all freshwater fish as well as migrating fish, including sea trout and whitefish, are of public health importance if consumed raw, since they may carry viable parasites. More research is needed to elucidate the importance of C. osculatum from fish as a source of human infection, including pathogenicity of this parasite and the anatomic distribution of the parasite in edible parts of the fish. In order to definitively identify species of anisakids, genetic/molecular methods should be more widely applied to material from all hosts of the Baltic Sea. Surveillance of anisakiasis and other parasitic infections in the human population in Baltic Sea countries should be improved.

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“…El primer caso de anisakidosis en nuestro país se describió el año 1976 2 , hasta ahora se han reportado 28 casos de anisakidosis, cuatro de ellos en pacientes pediátricos. La mayoría de los casos son producidos por P. decipiens 4 . En Bélgica se describió un caso de anisakidosis intestinal en un turista que adquirió la infección en un viaje a Chile y en Paraguay en un chileno que, por motivos de trabajo, viajó a ese país 4,10 .…”

Section: Parasitologíaunclassified

“…Generalmente, es una larva única, que una vez ingerida ingresa al organismo y puede localizarse en el esófago 12 , estómago 13 , duodeno, yeyuno, ileon o colón 14 . Existen ocho especies de Pseudoterranova: P. 4 . Pseudoterranovosis decipiens se encuentra con mayor frecuencia en la musculatura más que en las vísceras.…”

Section: Parasitologíaunclassified

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Pseudoterranovosis y sushi

et al. 2008

Rev. chil. infectol.

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A case of accidental ingestion of Pseudoterranova decipiens is reported, on account of this patient we review main concepts related to this emerging pathology in Chile. Consumption of raw fish in different preparations such as sushi or sashimi, cebiche and seafood is becoming more and more popular. Through intermediary hosts used in the preparation, one can acquire the third stage larval of Anisakis simplex or P. decipiens. These parasites frequently cause gastritis, acutely after the consumption of raw fish, or more rarely intestinal involvement. It may also cause allergic symptoms such as urticaria, angioedema and anaphylactic shock. The larvae is eliminated spontaneously in most cases; others need to be removed by upper gastrointestinal endoscopic examination. In Chile, the most common species is P. decipiens, which are generally no invasive, rarely migrate beyond the stomach and cause mild or no symptoms. Prevention strategies include avoid eating raw fish or undercooked seafood containing the parasite, to cook food with high temperatures or to freeze raw fish prior to preparation of meals, which inactivates the larvae.Key words: Anisakidosis, anisakiosis, pseudoterranovosis, Anisakis simplex, Pseudoterranova decipiens, foodborne parasitic infections, fishborne parasitic infections, zoonoses.Palabras clave: anisakidosis, anisakiosis, pseudoterranovosis, Anisakis simplex, Pseudoterranova decipiens, enfermedades parasitarias transmitidas por alimentos, enfermedades parasitarias transmitidas por peces y mariscos, zoonosis. Introduccióne estima que las infecciones parasitarias transmitidas por alimentos afectan a más de 50 millones de personas en el mundo, cifra probablemente sub-estimada por la dificultad en el diagnóstico y una sub-notificación. La mayor incidencia de estas infecciones se encuentra en el Este y Sudeste asiático, situación que se está haciendo cada vez más frecuente en nuestro medio con los viajes a destinos exóticos y la incorporación de la comida oriental a los menús tradicionales. Las infecciones parasitarias son el resultado de la ingesta de alimentos crudos o mal cocidos. Comentario editorial en página 196. La mayoría de estos cuadros son producidos por nemátodos, tremátodos, céstodos y protozoos 1 . Presentamos el caso de una paciente que tras visitar un restaurante de comida japonesa, elimina con la tos una forma juvenil de nemátodo. Caso ClínicoPaciente de 30 años, sexo femenino, sana, residente en la ciudad de Santiago. Asistió a un restaurante de comida japonesa, donde degustó sushi de variados sabores, algunos de ellos preparados con salmón crudo. Al día siguiente, comenzó con tos y estornudos, se

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Human Pseudoterranovosis, an Emerging Infection in Chile

Cited by 51 publications

References 12 publications

TheAnisakis simplexAni s 7 major allergen as an indicator of trueAnisakisinfections

TheAnisakis simplexAni s 7 major allergen as an indicator of trueAnisakisinfections

Scientific Opinion on assessment of epidemiological data in relation to the health risks resulting from the presence of parasites in wild caught fish from fishing grounds in the Baltic Sea

Pseudoterranovosis y sushi

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