Human slan (6-sulfo LacNAc) dendritic cells are inflammatory dermal dendritic cells in psoriasis and drive strong T 17/T 1 T-cell responses

Hänsel, Anja; Günther, Claudia; Ingwersen, Jens; Starke, Josephine; Schmitz, Marc; Bachmann, Michael; Meurer, Michael; Rieber, Ernst Peter; Schäkel, Knut

doi:10.1016/j.jaci.2010.12.009

Cited by 195 publications

(256 citation statements)

References 39 publications

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“…10a,b). As expected 14 , CCR2, CCR3, CCR5 and CXCR3 were expressed neither in slanDCs from healthy donors nor in slanDCs from CCR subjects. Importantly, chemotaxis induced by CXCR4, CX3CR1 or C5aR ligands was substantially equivalent in slanDCs derived from CCR subjects and healthy controls (Fig.…”

supporting

confidence: 76%

“…12). Functionally, slanDCs stand out for their remarkable capacity to produce tumour necrosis factor alpha (TNFa) and IL-12p70 upon stimulation with discrete toll-like receptor ligands 13,14 . In addition, they are potent inducers of primary antigen-specific T-cell responses in vitro 11 , and show a superior programming of Th1/Th17 cell polarization as compared with classical CD1c þ DCs 14 .…”

mentioning

confidence: 99%

“…Functionally, slanDCs stand out for their remarkable capacity to produce tumour necrosis factor alpha (TNFa) and IL-12p70 upon stimulation with discrete toll-like receptor ligands 13,14 . In addition, they are potent inducers of primary antigen-specific T-cell responses in vitro 11 , and show a superior programming of Th1/Th17 cell polarization as compared with classical CD1c þ DCs 14 . Furthermore, slanDCs induce in vitro tumour-specific cytotoxic T cells and strongly promote natural killer (NK) cell proliferation, NK cytotoxic activity and, in cooperation with neutrophils, NK-derived interferon-gamma (IFNg) production [15][16][17] .…”

mentioning

confidence: 99%

“…slanDCs are known to accumulate in peripheral tissues during chronic and autoimmune inflammatory disorders, such as Crohn's disease, rheumatoid arthritis and psoriasis 13,14,17 . Given their potent proinflammatory properties and propensity to tightly interact with epithelial cells, we posited that slanDCs could represent a hitherto unrecognized cellular component of the carcinoma microenvironment.…”

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slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells

et al. 2014

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Dendritic cells (DCs) initiate adaptive immune responses to cancer cells by activating naive T lymphocytes. 6-sulfo LacNAc þ DCs (slanDCs) represent a distinct population of circulating and tissue proinflammatory DCs, whose role in cancer immune surveillance is unknown. Herein, by screening a large set of clinical samples, we demonstrate accumulation of slanDCs in metastatic tumour-draining lymph nodes (M-TDLN) from carcinoma patients. Remarkably, slanDCs are absent at the primary carcinoma site, while their selective nodal recruitment follows the arrival of cancer cells to M-TDLN. slanDCs surround metastatic carcinoma deposits in close proximity to dead cells and efficiently phagocytose tumour cells. In colon carcinoma patients, the contingent of circulating slanDCs remains intact and competent in terms of IL-12p70 and tumour necrosis factor alpha production, induction of T-cell proliferation and migratory capacity to a set of chemokines produced in M-TDLN. We conclude that activated slanDCs represent previously unrecognized players of nodal immune responses to cancer cells.

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confidence: 99%

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slanDCs selectively accumulate in carcinoma-draining lymph nodes and marginate metastatic cells

et al. 2014

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“…Des cellules exprimant les molécules du CMH II (HLA-DR) et CD11c, présentes dans la peau de patients atteints de psoriasis et absentes dans la peau saine, ont également été observées et nommées cellules dendritiques dermiques inflammatoires [24]. Néanmoins, ces cellules ont ensuite été identifiées comme étant similaires à des cellules du sang exprimant CD16 + et la 6-sulfo LacNAc (sous-population de monocytes) [25,26]. De plus, les caractéristiques de ces cellules les rapprochent plus des macrophages que des cellules dendritiques [27].…”

Section: Les Cellules Dendritiques Inflammatoires Humainesunclassified