Human Stem Cells for Craniomaxillofacial Reconstruction

Jalali, Morteza; Kirkpatrick, William Niall Alexander; Cameron, Malcolm Gregor; Pauklin, Siim; Vallier, Ludovic

doi:10.1089/scd.2013.0576

Cited by 7 publications

(4 citation statements)

References 169 publications

(164 reference statements)

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“…Added to the demand, organ donation is still less common in many countries such as China and Japan. Apart from internal organs, there is also increasing demand for human cell and tissue materials to regrow missing bones, muscles, connective tissues, neural plexi, and skin in the face, neck, and extremities resulting from injuries in wars, motor vehicle-related accidents, burns, and natural disasters (Jalali et al, 2014;van Zuijlen et al, 2015).…”

Section: Biomedical Applications and Perspectives Of Next Generation Human Organoidsmentioning

confidence: 99%

Next generation organoids for biomedical research and applications

Lou

Leung

2018

Biotechnology Advances

100

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Organoids are in vitro cultures of miniature fetal or adult organ-like structures. Their potentials for use in tissue and organ replacement, disease modeling, toxicology studies, and drug discovery are tremendous. Currently, major challenges facing human organoid technology include (i) improving the range of cellular heterogeneity for a particular organoid system, (ii) mimicking the native micro- and matrix-environment encountered by cells within organoids, and (iii) developing robust protocols for the in vitro maturation of organoids that remain mostly fetal-like in cultures. To tackle these challenges, we advocate the principle of reverse engineering that replicates the inner workings of in vivo systems with the goal of achieving functionality and maturation of the resulting organoid structures with the input of minimal intrinsic (cellular) and environmental (matrix and niche) constituents. Here, we present an overview of organoid technology development in several systems that employ cell materials derived from fetal and adult tissues and pluripotent stem cell cultures. We focus on key studies that exploit the self-organizing property of embryonic progenitors and the role of designer matrices and cell-free scaffolds in assisting organoid formation. We further explore the relationship between adult stem cells, niche factors, and other current developments that aim to enhance robust organoid maturation. From these works, we propose a standardized pipeline for the development of future protocols that would help generate more physiologically relevant human organoids for various biomedical applications.

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Section: Biomedical Applications and Perspectives Of Next Generation Human Organoidsmentioning

confidence: 99%

Next generation organoids for biomedical research and applications

Lou

Leung

2018

Biotechnology Advances

100

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“…Stem cells are an ideal target for manipulation in translational regenerative medicine because of their self-renewal and ability to give rise to multiple cell types. Although regenerative medicine research has the potential to be translated into clinical practice, the biology of haemopoietic pluripotent stem cells (HPSCs) and in vitro-produced cell types, and tissues for the craniomaxillofacial area needs to be better understood before they can be used safely inpatient [ 19 ]. The osteogenic development of unrestrained somatic stem cells was increased by porous poly(L-lactic acid) (PLLA)-based scaffolds with hydroxyapatite (HA) coated on the surface of nanofibers.…”

Section: Reviewmentioning

confidence: 99%

Use of Nanocomposites in Bone Regeneration

Masne¹,

Ambade²,

Bhugaonkar³

2022

Cureus

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This article examines the compositions of bone tissue grafting and presents tissue culture and engineering formally as an approach for orthopaedic surgery. We assessed articles on bone grafts, analyzed their properties, advantages, and restrictions, and delivered explanations on technologies, including bone-tissue engineering (BTE). Osteo graft materials range from real human bone autografts (self-grafts) to substitute materials that can be used as grafts. These can be used single-handedly or conjointly to improve bone healing and regeneration. Tissue engineering is a relatively newer and evolving alternative for reducing the challenges of bone grafts and improving the rehabilitation of bone fractures and defects. Shortly, the combination of scaffolds, healing factors, gene therapy, and, more recently, 3D printing of tissue-engineered constructs may yield new perceptions. Natural bone tissue has a nanocomposite structure that offers the right biological and physical characteristics. It is essential that the biomaterial resemble real bone tissue in order to regenerate bone tissue. Because they can offer the correct matrix environment, combine desirable biological features, and allow regulated, sequential distribution of numerous growth factors for the different phases of bone tissue regeneration, nanocomposites are the ideal alternative for bone tissue regeneration. This is because no single type of material can replicate the composition, structure, and characteristics of native bone. A relatively new class of materials called nanocomposite biomaterials combines a biopolymeric and biodegradable matrix structure with nanoscale fillers that are bioactive and easily resorbable. There are also some things to think about when using nanoparticles and nanocomposites as scaffolds in clinical settings for bone tissue engineering.

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“…When the field of cell therapy “known later on as tissue engineering and regenerative medicine” was introduced 30 years ago, no one believed that it would extend to the dental and maxillofacial region, while the more critical organs and tissues were on the top of the priority list e.g., liver, kidney, heart, etc. If we look today, the most successful applications of tissue engineering and regenerative medicine are skin, cornea, bone, dental pulp, periodontal ligament, and alveolar bone; all related to the dental and head and neck area (Jalali et al, 2014 ; Chen F. M. et al, 2016 ; Miller et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Dental Mesenchymal Stem Cell-Based Translational Regenerative Dentistry: From Artificial to Biological Replacement

Marei

Backly

2018

Front. Bioeng. Biotechnol.

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Dentistry is a continuously changing field that has witnessed much advancement in the past century. Prosthodontics is that branch of dentistry that deals with replacing missing teeth using either fixed or removable appliances in an attempt to simulate natural tooth function. Although such “replacement therapies” appear to be easy and economic they fall short of ever coming close to their natural counterparts. Complications that arise often lead to failures and frequent repairs of such devices which seldom allow true physiological function of dental and oral-maxillofacial tissues. Such factors can critically affect the quality of life of an individual. The market for dental implants is continuously growing with huge economic revenues. Unfortunately, such treatments are again associated with frequent problems such as peri-implantitis resulting in an eventual loss or replacement of implants. This is particularly influential for patients having co-morbid diseases such as diabetes or osteoporosis and in association with smoking and other conditions that undoubtedly affect the final treatment outcome. The advent of tissue engineering and regenerative medicine therapies along with the enormous strides taken in their associated interdisciplinary fields such as stem cell therapy, biomaterial development, and others may open arenas to enhancing tissue regeneration via designing and construction of patient-specific biological and/or biomimetic substitutes. This review will overview current strategies in regenerative dentistry while overviewing key roles of dental mesenchymal stem cells particularly those of the dental pulp, until paving the way to precision/translational regenerative medicine therapies for future clinical use.

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Human Stem Cells for Craniomaxillofacial Reconstruction

Cited by 7 publications

References 169 publications

Next generation organoids for biomedical research and applications

Next generation organoids for biomedical research and applications

Use of Nanocomposites in Bone Regeneration

Dental Mesenchymal Stem Cell-Based Translational Regenerative Dentistry: From Artificial to Biological Replacement

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