Ensuring that human performance factors are adequately considered during the system engineering process has proven to be a challenging task for Human Factors and Human Systems Integration (HSI) practitioners. Programs that do not sufficiently include HSI as an integral aspect of planning and execution are at risk of diminished user performance and total system performance, leading to costly and time-consuming re-work. To encourage a greater involvement of HSI in systems engineering, the HSI Framework (HSIF) was developed to explicitly incorporate HSI tasks and products in all stages of system acquisition. The HSIF is a web application that contains general and domain-specific HSI activities, references, and related products. For HSI Practitioners and System Engineers, the HSIF provides technical guidance and best practices, thereby fostering early, explicit, and properly-scoped HSI efforts. In turn, Program Managers and Technical Authorities are provided with the information needed to accurately assess and manage human performance-related risks, leading to relevant, effective, and integrated system performance.