Because the average number of missing people in our country is more than 20,000 per year, determining how to efficiently locate missing people is important. The traditional method of finding missing people involves deploying fixed cameras in some hotspots to capture images and using humans to identify targets from these images. However, in this approach, high costs are incurred in deploying sufficient cameras in order to avoid blind spots, and a great deal of time and human effort is wasted in identifying possible targets. Further, most AI-based search systems focus on how to improve the human body recognition model, without considering how to speed up the search in order to shorten the search time and improve search efficiency, which is the aim of this study. Hence, by exploiting the high-mobility characteristics of unmanned aerial vehicles (UAVs), this study proposes an integrated YOLOv5 and hierarchical human-weight-first (HWF) path planning framework to serve as an efficient UAV searching system, which works by dividing the whole searching process into two levels. At level one, a searching UAV is dispatched to a higher altitude to capture images, covering the whole search area. Then, the well-known artificial intelligence model YOLOv5 is used to identify all persons in the captured images and compute corresponding weighted scores for each block in the search area, according to the values of the identified human bodies, clothing types, and clothing colors. At level two, the UAV lowers its altitude to sequentially capture images for each block, in descending order according to its weighted score at level one, and it uses the YOLOv5 recognition model repeatedly until the search target is found. Two improved search algorithms, HWFR-S and HWFR-D, which incorporate the concept of the convenient visit threshold and weight difference, respectively, are further proposed to resolve the issue of the lengthy and redundant flight paths of HWF. The simulation results suggest that the HWF, HWFR-S, and HWFR-D search algorithms proposed in this study not only effectively reduce the length of a UAV’s search path and the number of search blocks but also decrease the search time required for a UAV to locate the search target, with a much higher search accuracy than the two traditional search algorithms. Moreover, this integrated YOLOv5 and HWF framework is implemented and tested in a real scenario to demonstrate its capability in enhancing the efficiency of a search and rescue operation.