Humoral immune response in Hepatitis B virus infections

The status of humoral immunity in occult HBV infection in south-eastern Iranian patients

“…Martinetti M et al, reported that reduced humoral response to HBV in some neonates was associated with polymorphisms in HLA class Ι and ΙΙ genes [24]. Vranckx R et al, reported that humoral immunity can also be defective in chronic HBV infected patients [25]. Other studies have also shown that some vaccinated adults are unable to produce specific IgG against HBsAg [26].…”

Immunity to Sexually Transmitted Infections

“…Initial studies of the levels of total Ig in symptom-free HBsAg carriers and patients with acute hepatitis B indicated that the levels of IgG are unchanged, whereas the levels of IgA and IgM are reduced compared to healthy HBsAgnegative controls (Vranckx, 1983). Antibody responses directed against envelope antigens are detectable in sera of individuals who clear the virus and recover from acute hepatitis; such antibodies are usually undetectable in chronic HBV infections.…”

Current information on the immunologic status of occult hepatitis B infection

“…Martinetti and colleagues 40 reported that reduced humoral response to HBV in some neonates was associated with polymorphisms in HLA Class I and II genes. Vranckx 41 reported that humoral immunity can also be defective in chronic HBV‐infected patients 42 . Other studies have also shown that some vaccinatedadults are unable to produce specific IgG against HBsAg 43 .…”