Hürthle Cell Thyroid Carcinoma Metastatic to the Sigmoid Colon

Abstract

Prognosis of differentiated thyroid cancer is favorable in the majority of cases. However, distant metastases occur in 10-15% of cases, predominantly in lungs and bones, especially in older patients exhibiting poorly differentiated forms or advanced stages. We report a case history of Hürthle cell thyroid carcinoma metastasized to the sigmoid colon. To the best of our knowledge, this location has never been described before. This case history illustrates the difficulties of diagnosis and treatment in patients whose metastases do not concentrate radioiodine. The interest of different imaging modalities, including fluoro-deoxy-glucose positron emission tomography scan and somatostatin receptor scintigraphy, is discussed.

Hürthle Cell Neoplasms of the Thyroid

“…33 The sonographic appearance of HCNs has received scant attention in the literature, and nearly all reports have been clinical descriptions of single cases. [16][17][18][19] The described tumors were found to be homogeneously hypoechoic or cystic. In our series of patients, the sonographic appearance of HCNs varied from hypoechoic to isoechoic and hyperechoic regardless of the sizes or pathologic characteristics of the lesions.…”

“…However, there are scant references reporting the sonographic appearance of HCNs in the literature, with nearly all reports being clinical descriptions of single cases. [16][17][18][19] The objective of this study was to analyze the appearance of pathologically proven benign and malignant HCNs on sonography and to define the spectrum of sonographic findings of these lesions.…”

Image-guided radiation therapy using surgical clips for localization of colonic metastasis from thyroid cancer

“…Given the complicated and unfortunate course of disease for this patient, palliative management was recommended to control lower GI bleeding, avoid further transfusions, and improve quality of life. Rare abdominal and pelvic metastasis of papillary thyroid cancer presented a challenge for management, and only a handful of reports have been published [ 4 - 6 ]. One report documented a 19-year old girl with a rare cribriform-morular variant of PTC, associated with familial adenomatous polyposis syndrome [ 4 ].…”

“…Gastrointestinal metastases of thyroid cancer account for 0.5-1% metastatic sites [ 3 ]. To date, there are only a small number of patient reports documenting metastatic disease from the thyroid to the colon [ 4 - 6 ].…”

Solitary spinal metastasis of Hürthle cell thyroid carcinoma

“…4 HCC of the thyroid is considered a subtype of follicular thyroid carcinoma, a group of well-differentiated thyroid malignancies. [6][7][8] The most common sites of metastasis for HCC are lung, bone, and liver, 4,17 but it is also known to metastasize to the colon, 18 small bowel and omentum, 19 esophagus, 20 adrenal gland, 21 kidney, 22 uterus, 23 meninges, 24 uvea, 25 retro-orbital space, 26 and wound drain sites. [6][7][8] The most common sites of metastasis for HCC are lung, bone, and liver, 4,17 but it is also known to metastasize to the colon, 18 small bowel and omentum, 19 esophagus, 20 adrenal gland, 21 kidney, 22 uterus, 23 meninges, 24 uvea, 25 retro-orbital space, 26 and wound drain sites.…”